Abstract: The p21 biomarker is utilized in the evaluation of whether a patient is suffering from kidney injury or failure, and can be used in methods of treating kidney injury or failure by determining the appropriateness of one or more of initiating renal replacement therapy, withdrawing delivery of compounds that are known to be damaging to the kidney, delaying or avoiding procedures that are known to be damaging to the kidney, and modifying diuretic administration.

Abstract: A blower includes a housing including an inlet and an outlet, a bearing-housing structure provided to the housing and adapted to rotatably support a rotor, a motor provided to the bearing-housing structure and adapted to drive the rotor, and an impeller provided to the rotor. The bearing-housing structure includes a bearing shaft having a bearing surface that rotatably supports the rotor. The bearing shaft provides only a single bearing of the non-ball bearing type for the rotor.

Abstract: The subject disclosure relates to systems, devices, and methods for executing operations related to procurement of individualized medicine therapies. Also disclosed are embodiments systems, methods, and devices for accessing a wide range of individualized medicine platform modules. Furthermore, disclosed herein are individualized medicine platform systems, methods and devices communicatively coupled to blockchain computing systems comprising several nodes. The disclosed systems, methods, and devices also generate chain of custody and chain of identity event data.

Abstract: The present invention involves a novel method for treatment of chronic kidney disease comprising administering a compound that induces a stress protein response in a patient, and administering a potent antioxidant if the patent's response is below a predefined level. It also involves a quantitative measure for determining a patient's antioxidant reserve capacity.

Abstract: Disclosed herein are electrotransfer (ET) methods for delivering therapeutic agents to tumors. Also disclosed are methods of using the ET methods for differential delivery of an agent to more than one tissue. For example, the ET methods can be used to deliver soluble peptides of PD1 to tumor tissue to block normal PD1-PDL1 binding while separately using the ET methods to deliver PD1 or PDL1 antigen to another tissue, such as skin or muscle, to induce systemic and polyclonal checkpoint inhibitor antibodies.

Abstract: The present invention provides a system and method for measuring an impedance of one or more target cells before and after an electroporation protocol has been applied to the one or more target cells. The result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize the electrical treatment for a particular target cell or cellular tissue.

Abstract: A metadata catalog may store metadata about data sources. The metadata may define table, column, partition and/or data formats, as well as title information, textual descriptions, modification information, data schemas and access information, such as location and connection information. A metadata catalog service may provide a shared, persistent, central repository for the metadata. The metadata of the catalog may be published via multiple access mechanisms and programmatically obtained and processed by other programs via the metadata catalog service. Metadata consumers may utilize the metadata catalog service to perform various metadata tasks, such as metadata retrieval, creation, addition, modification and/or deletion. The metadata catalog service may be directly integrated into existing data analytic tools as a persistent and durable metadata store allowing users to utilize the broad set of data processing tools.

Abstract: A recommendation system is provided, including a non-transitory memory, a processor, and a player interface. The non-transitory memory is configured to store a database including the player's playing history for a plurality of electronic gaming machines. The processor is coupled to the non-transitory memory and configured to gain access to the database and execute computer-executable instructions. The computer-executable instructions include a promotions engine operable to generate a list of electronic gaming machine recommendations personalized for a player based at least on the player's playing history. The promotions engine is further operable to generate a promotion based on the list. The player interface is accessible by the player and includes a display configured to present the promotion.

Abstract: A transcutaneous neurostimulation therapy system can include an electrostimulation electronics unit, including first and second neurostimulation output which can be respectively coupled to first and second neurostimulation skin electrodes, and the electrostimulation electronics unit can include or be coupled to a rechargeable battery. The transcutaneous neurostimulation therapy system can also include battery charging circuitry configured for being coupled via the first and second neurostimulation output terminals to the electrostimulation electronics unit for charging the battery of the electrostimulation electronics unit through the first and second neurostimulation skin electrodes.

Abstract: A recommendation system is provided, including a non-transitory memory, a processor, and a player interface. The non-transitory memory is configured to store a database including the player's playing history for a plurality of electronic gaming machines. The processor is coupled to the non-transitory memory and configured to gain access to the database and execute computer-executable instructions. The computer-executable instructions include a promotions engine operable to generate a list of electronic gaming machine recommendations personalized for a player based at least on the player's playing history. The promotions engine is further operable to generate a promotion based on the list. The player interface is accessible by the player and includes a display configured to present the promotion.

Abstract: A transcutaneous neurostimulation therapy system can include an electrostimulation electronics unit, including first and second neurostimulation output which can be respectively coupled to first and second neurostimulation skin electrodes, and the electrostimulation electronics unit can include or be coupled to a rechargeable battery. The transcutaneous neurostimulation therapy system can also include battery charging circuitry configured for being coupled via the first and second neurostimulation output terminals to the electrostimulation electronics unit for charging the battery of the electrostimulation electronics unit through the first and second neurostimulation skin electrodes.

Abstract: A system for manufacturing boiler tubes includes a first spindle for receiving a first tube having a first weld preparation, a second spindle for receiving a second tube having a second weld preparation, the first spindle and the second spindle being rotatable synchronously, and a welding device having a first weld head. The welding device is configured to automatically weld the first tube to the second tube according to a control routine stored in memory to produce a boiler tube.

Abstract: A method of detecting a back of a shelf for supporting objects includes: obtaining an image depicting a shelf having a shelf edge and a support surface extending from the shelf edge to a shelf back; decomposing the image into a plurality of patches; for each patch: generating a feature descriptor; based on the feature descriptor, assigning one of a shelf back classification and a non-shelf back classification to the patch; generating a mask corresponding to the image, the mask containing an indication of the classification assigned to each of the patches; and presenting the mask.

Abstract: A method includes obtaining a point cloud captured by a depth sensor, and image data captured by an image sensor, the point cloud and the image data representing a support structure bearing a set of objects; obtaining an image boundary corresponding to an object from the set of objects; determining a portion of the point cloud corresponding to the image boundary; selecting, from the determined portion, a subset of points corresponding to a forward surface of the object; and generating a three-dimensional position of the object based on the forward surface.

Abstract: A method of determining a support structure depth of a support structure having a front and a back separated by the support structure depth includes: obtaining a point cloud of the support structure, and a mask indicating, for a plurality of portions of an image of the support structure captured from a capture pose, respective confidence levels that the portions depict the back of the support structure; selecting, from the point cloud, an initial set of points located within a field of view originating at the capture pose; selecting, from the initial set of points, an unoccluded subset of depth measurements, the depth measurements in the unoccluded subset corresponding to respective image coordinates; retrieving, from the mask, a confidence level for each of the depth measurements in the unoccluded subset; and based on the depth measurements in the unoccluded subset and the retrieved confidence levels, determining the support structure depth.

Abstract: A method includes obtaining a point cloud captured by a depth sensor, and image data captured by an image sensor, the point cloud and the image data representing a support structure bearing a set of objects; obtaining an image boundary corresponding to an object from the set of objects; determining a portion of the point cloud corresponding to the image boundary; selecting, from the determined portion, a subset of points corresponding to a forward surface of the object; and generating a three-dimensional position of the object based on the forward surface.

Abstract: A method of label detection includes: obtaining, by an imaging controller, an image depicting a shelf; increasing an intensity of a foreground subset of image pixels exceeding an upper intensity threshold, and decreasing an intensity of a background subset of pixels below a lower intensity threshold; responsive to the increasing and the decreasing, (i) determining gradients for each of the pixels and (ii) selecting a candidate set of the pixels based on the gradients; overlaying a plurality of shelf candidate lines on the image derived from the candidate set of pixels; identifying a pair of the shelf candidate lines satisfying a predetermined sequence of intensity transitions; and generating and storing a shelf edge bounding box corresponding to the pair of shelf candidate lines.

Abstract: A method in an imaging controller of detecting obstructions on a front of a support structure includes: obtaining (i) a point cloud of the support structure and an obstruction, and (ii) a support structure plane corresponding to the front of the support structure; for each of a plurality of selection depths: selecting a subset of points from the point cloud based on the selection depth; detecting obstruction candidates from the subset of points and, for each obstruction candidate: responsive to a dimensional criterion being met, determining whether the obstruction candidate meets a confirmation criterion; when the obstruction candidate meets the confirmation criterion, identifying the obstruction candidate as a confirmed obstruction; and presenting obstruction detection output data including the confirmed obstructions.

Abstract: A method of mobile automation apparatus localization in a navigation controller includes: controlling a depth sensor to capture a plurality of depth measurements corresponding to an area containing a navigational structure; selecting a primary subset of the depth measurements; selecting, from the primary subset, a corner candidate subset of the depth measurements; generating, from the corner candidate subset, a corner edge corresponding to the navigational structure; selecting an aisle subset of the depth measurements from the primary subset, according to the corner edge; selecting, from the aisle subset, a local minimum depth measurement for each of a plurality of sampling planes extending from the depth sensor; generating a shelf plane from the local minimum depth measurements; and updating a localization of the mobile automation apparatus based on the corner edge and the shelf plane.

Abstract: A method includes obtaining a point cloud captured by a depth sensor, and image data captured by an image sensor, the point cloud and the image data representing a support structure bearing a set of objects; obtaining an image boundary corresponding to an object from the set of objects; determining a portion of the point cloud corresponding to the image boundary; selecting, from the determined portion, a subset of points corresponding to a forward surface of the object; and generating a three-dimensional position of the object based on the forward surface.