Abstract: Disclosed are compounds of formula (I): and pharmaceutically acceptable N-oxides, salts, hydrates, solvates, complexes, bioisosteres, metabolites, and prodrugs thereof, which are of use in the treatment of infection with, and diseases caused by, Clostridium difficile.

Abstract: According to the invention there is provided a balun including: a slotline which is coupled to an input line and an output line, in which at least a portion of the slotline is sandwiched between a first and a second layer of dielectric material.

Abstract: A training system for developing tackle technique and tackle follow-up technique at a range of heights in contact sports, especially American football, comprises a first padded tackling training apparatus for targeted training of tackle technique tackle follow-up technique at a first level corresponding to a relatively low body height, a second padded tackling training apparatus for targeted training of tackle technique and tackle follow-up technique at a second level corresponding to a medial body height; and a third padded tackling training apparatus for targeted training of tackle technique and tackle follow-up technique at a third level corresponding a relatively high body height facilitates coaching of improved technique for tackling and follow-up technique in contact sports, particularly in American football.

Abstract: A method of and apparatus (10) for providing a personalized audio-visual instructional aid for assisting a person (11) to emulate preferred positions and/or movements in undertaking an activity by capturing position and/or movement data of the person (11) or an object associated with and controlled by the person undertaking the activity using position and/or movement sensing devices such as MEMS sensors (13) on the person (11) or object and using a computer (16) to analyze and compare the captured data with pre-stored data relating to preferred positions and/or movement in undertaking the activity and generating a visual presentation (19) based on the differences between the captured position and/or movement of the person or object and the preferred positions and/or movement and adding to the generated visual presentation, audio instructional comments relating to the differences.

Abstract: A test sample is provided for testing performance of measuring and monitoring equipment for production lines, for example for foodstuffs or pharmaceuticals, and in particular, contamination monitoring equipment employing X-rays and/or metal detectors to spot foreign bodies in packaged products. The test sample may comprise a laminated card enclosing a standardised test piece such as a metal particle of specified size. The card or other sample may bear at least one identification containing a barcode, readable by an optical scanner. To test the equipment, a card is placed on a product package passing through the equipment, the optical scanner reads the barcode to confirm that the correct test sample has been submitted, and the results for the test sample are recorded in a computer log. If the results do not match those expected from the particular test sample submitted, the equipment fails the test and requires recalibration or repair.

Abstract: In one embodiment, a method may include retrieving, via a processor, a fundamental frequency of a cylinder type from a memory communicatively coupled to the processor, receiving, via the processor, a first signal from a first knock sensor disposed on a cylinder. The cylinder is disposed in an engine. The method may also include deriving whether a number of amplitudes of the first signal at the fundamental frequency and one or more harmonic frequencies exceed an undesired installation threshold value, and identifying an asymmetric piston as having an undesired installation if the undesired installation threshold value exceeds the number of amplitudes of the first signal and the one or more harmonic frequencies.

Abstract: An oral dosage form to deliver diphenhydramine through the sublingual or buccal mucosa. The oral dosage form can contain diphenhydramine, or a pharmaceutically acceptable salt thereof, a permeability enhancer, and a buffering agent. The buffering agent can achieve a pH of about 7.0 to about 8.0. The diphenhydramine can completely dissolve within about 2 minutes.

Abstract: A feeding unit for receiving sealed packs from a forming unit arranged to form the packs and feed the packs to a folding unit arranged to fold the packs so as to obtain folded packages comprises a feeding conveyor having at least one carrying element arranged for delivering the packs to the folding unit at an outlet region of the feeding unit, the feeding unit further comprising a braking conveyor arranged for slowing down the packs so that the packs are kept in contact with the at least one carrying element at the outlet region.

Abstract: Techniques and tools for quantum key distribution (“QKD”) between a quantum communication (“QC”) card, base station and trusted authority are described herein. In example implementations, a QC card contains a miniaturized QC transmitter and couples with a base station. The base station provides a network connection with the trusted authority and can also provide electric power to the QC card. When coupled to the base station, after authentication by the trusted authority, the QC card acquires keys through QKD with a trust authority. The keys can be used to set up secure communication, for authentication, for access control, or for other purposes. The QC card can be implemented as part of a smart phone or other mobile computing device, or the QC card can be used as a fillgun for distribution of the keys.

Abstract: Techniques and tools for implementing protocols for secure multi-party communication after quantum key distribution (“QKD”) are described herein. In example implementations, a trusted authority facilitates secure communication between multiple user devices. The trusted authority distributes different quantum keys by QKD under trust relationships with different users. The trusted authority determines combination keys using the quantum keys and makes the combination keys available for distribution (e.g., for non-secret distribution over a public channel). The combination keys facilitate secure communication between two user devices even in the absence of QKD between the two user devices. With the protocols, benefits of QKD are extended to multi-party communication scenarios. In addition, the protocols can retain benefit of QKD even when a trusted authority is offline or a large group seeks to establish secure communication within the group.

Abstract: A cooling assembly for a gas turbine system includes a turbine nozzle having at least one channel comprising a channel inlet configured to receive a cooling flow from a cooling source, wherein the at least one channel directs the cooling flow through the turbine nozzle in a radial direction at a first pressure to a channel outlet. Also included is an exit cavity for fluidly connecting the channel outlet to a region of a turbine component, wherein the region of the turbine component is at a second pressure, wherein the first pressure is greater than the second pressure.

Abstract: A gas/fluid mass exchange apparatus includes a gas permeable membrane which is arranged to separate a first region for receiving a gas flow, from a second region for receiving a fluid flow. The apparatus further a support element which is arranged to maintain the shape and orientation of the membrane.

Abstract: An accessory tray is connected to, or extends integrally from, a shopping cart handle and extends a limited distance forward from the handle. The tray extends forward above, but not significantly interfering with, the child-seat area of the cart. Preferably, the forward extremity is not directly connected or attached to the cart, but rather the tray is cantilevered from its rear end/edge fixed to/at the handle and extends otherwise unconnected forward from the handle. A forward tray portion may rest on, or be close to, an upper portion/end of the cart rear wall. The preferred tray is substantially planar, featuring a single, flat platform with an upending rim, wherein no part extends above said top level of the handle. The tray remains in place for nesting of multiple carts, and is received in a space between nested portions of the cart to which it is connected.

Abstract: Methods and circuitry are provided for finding an optimum vector for motion-compensated prediction in video coding. Processing circuitry is operable to define a block in an image, the defined block having a plurality of pixels. A first set of residuals is calculated using a first motion vector. Each residual of the first set of residuals corresponds to a respective pixel within the plurality of pixels. Additionally, a first plurality of absolute differences is calculated. Each absolute difference in the first plurality of absolute differences is between a pair of residuals in the first set of residuals. The first plurality of absolute differences is summed, and is compared to sums of absolute differences of residuals calculated using other motion vectors. The motion vector corresponding to the lowest sum may be identified as an optimum motion vector.

Abstract: The present invention relates to compounds of formula (I) wherein R, R1, X1 to X5 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as their use as medicaments.

Abstract: A high-pressure die casting apparatus including a shot sleeve extending through a first die half to a molding surface, and a plunger received in the shot sleeve is provided. The shot sleeve includes a side wall presenting a fluid passageway and a partial end wall disposed in a fixed position relative to the side wall. The partial end wall defines a wall opening adjacent the molding surface. Fluid is poured into the shot sleeve while the die apparatus is open, and the partial end wall prevents the fluid from flowing out of the shot sleeve. The plunger then presses the material into the mold cavity until only a portion of the material remains in the shot sleeve and blocks the wall opening. After the solidified material is ejected from the apparatus, the portion of material blocking the wall opening prevents lubricant from entering the shot sleeve.

Abstract: Blood is treated externally to a human or animal body, the blood having been extracted from a first human or animal body for delivery to a second human or animal body. The temperature and/or composition of the blood are controlled.

Abstract: Combined blood flow and blood pressure measurements are used for the calculation of central vascular blood flow parameters. Blood flow measurements may be made simultaneously with arterial pressure measured either centrally or peripherally and central venous pressure for the monitoring of human subjects. A combined blood flow and blood pressure measurement device for hemodynamic monitoring may include a Doppler ultrasound probe utilizing a continuous wave or pulse wave ultrasound beam for the measurement of blood flow in the aorta, combined with arterial pressure measurement, or signal input from a suitable pressure transducer system from one of either the radial, brachial, dorsalis pedis or femoral artery. The ultrasound probe may comprise either an esophageal or suprasternal ultrasound probe, while the blood pressure measurement may be either an electronic transducer blood pressure sphygmomanometer on the arm, or a finger cot infrared light optical pulse detector.

Abstract: Disclosed herein are methods of treating CMV (cytomegalovirus) retinitis in a human patient in need thereof, comprising administering to the human patient a population of allogeneic T cells comprising CMV-specific T cells, wherein the human patient is infected with HIV or has been the recipient of a solid organ transplant.

Abstract: Computing systems, computer-readable media, and methods may include determining at least one automated sequence to be performed during a portion of a drilling operation by a drilling system. The at least one automated sequence may include performing one or more actions to cause a response in the drilling system. The method may include performing, during the drilling operation, the at least one automated sequence. Further, the method may include measuring, during the performance of the at least one automated sequence, one or more responses in the drilling system. The one or more responses may be measured within a wellbore undergoing the drilling operations and at a surface of the wellbore. The method may include modifying a model of the drilling system based at least in part of the one or more responses that were measured during the performance of the at least one automated sequence.