Abstract: Antisense oligomers complementary to a selected target site in the human dystrophin gene to induce exon 52 skipping are described.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 44 skipping are described.

Abstract: Antisense oligomers complementary to a selected target site in the human dystrophin gene to induce exon 45 skipping are described.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 44 skipping are described.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 44 skipping are described.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 53 skipping are described.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 53 skipping are described.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 44 skipping are described.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 44 skipping are described.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 53 skipping are described.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 44 skipping are described.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 53 skipping are described.

Abstract: A method and oligonucleotide compound for inhibiting replication of a nidovirus in virus-infected animal cells are disclosed. The compound (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the infected cells, (iii) contains between 8-25 nucleotide bases, and (iv) has a sequence capable of disrupting base pairing between the transcriptional regulatory sequences in the 5? leader region of the positive-strand viral genome and negative-strand 3? subgenomic region. In practicing the method, infected cells are exposed to the compound in an amount effective to inhibit viral replication.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 44 skipping are described.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 44 skipping are described.

Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 53 skipping are described.

Abstract: A method and oligonucleotide compound for inhibiting replication of a nidovirus in virus-infected animal cells are disclosed. The compound (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the infected cells, (iii) contains between 8-25 nucleotide bases, and (iv) has a sequence capable of disrupting base pairing between the transcriptional regulatory sequences in the 5? leader region of the positive-strand viral genome and negative-strand 3? subgenomic region. In practicing the method, infected cells are exposed to the compound in an amount effective to inhibit viral replication.

Abstract: The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Enterovirus and/or Rhinovirus infection in a mammal. The antisense antiviral compounds are substantially uncharged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 5? untranslated region identified by SEQ ID NO:7.

Abstract: This invention provides for a rapid and convenient method of simultaneous collection of both genomic and diagnostic information from a single sample on a bibulous pad by differential extraction of the diagnostic information from the genomic information. It is a surprising discovery of this invention that a PCR assay on the contents of the bibulous pad provides results comparable in reliability, specificity, and sensitivity to the best available serum (blood) based assays. The assays of this invention can be used to confirm each other, either by detecting the genomic information leading to the diagnostic information, or by detecting in the genomic information, a predisposition to a disease and confirming the presence of the disease through diagnostic testing.

Abstract: A method and oligonucleotide compound for inhibiting replication of a nidovirus in virus-infected animal cells are disclosed. The compound (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the infected cells, (iii) contains between 8-25 nucleotide bases, and (iv) has a sequence capable of disrupting base pairing between the transcriptional regulatory sequences in the 5? leader region of the positive-strand viral genome and negative-strand 3? subgenomic region. In practicing the method, infected cells are exposed to the compound in an amount effective to inhibit viral replication.