Abstract: Disclosed herein is a case or cover for protecting the housing of a folding portable electronic device such as a smart phone with a folding display. The case or cover includes a first and second portion hingedly joined to a hinge protecting portion. The case or cover allows the encase phone to lie flat when in the fully opened position and included thinner first and second case portions proximate to the hinge cover to minimize the gaps between the case portions during the transition from a fully open to a fully closed position.

Abstract: Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A turbomachine engine includes a core engine having one or more compressor sections, one or more turbine sections that includes a power turbine, and a combustion chamber in flow communication with the compressor sections and turbine sections. The turbomachine engine also includes a shaft coupled to the power turbine and characterized by a midshaft rating (MSR) between two hundred (ft/sec)1/2 and three hundred (ft/sec)1/2. In one aspect, the shaft has a redline speed between fifty and two hundred fifty feet per second (ft/sec). In another aspect, the shaft has a length L, an outer diameter D, and a ratio of L/D between twelve and thirty-seven.

Abstract: A damping device that includes features for damping bending vibration of a shaft rotating about its axis of rotation and methods for damping bending vibration utilizing the damping device are provided. In one exemplary aspect, the damping device includes a damping disc operatively coupled with a shaft, e.g., of a turbine engine or shaft system. The damping disc is at least partially received within a chamber defined by a housing. The chamber of the housing is configured to receive a damping fluid. When the shaft is rotated about its axis of rotation, the damping disc is movable within the chamber to move the damping fluid such that the damping fluid absorbs bending vibration emitted by the shaft. The damping fluid moved by the damping disc dampens bending vibration emitted by the shaft.

Abstract: Disclosed herein is an improved packaging for a portable electronic device such as a smartphone. The packaging included features that allow the packaging to be used as an alignment or guide device to apply a screen protector to a screen of the portable electronic device.

Abstract: Aspects of the invention relate to antisense oligonucleotides directed to the interleukin 17 receptor (IL-17R), and other targets. Spherical nucleic acid formulations or compositions of antisense oligonucleotides and related methods of treatment are also provided.

Abstract: The present disclosure provides methods of treating and/or preventing cytokine storms with gemcabene or a pharmaceutically acceeptable salt thereof. Also disclosed are methods of treating inflammation caused by viral infections.

Abstract: Spherical nucleic acids (SNA) carrying self-aggregating oligonucleotides are described herein. Compositions of the SNA include discrete nanostructures that are not aggregated. Related methods are also described.

Abstract: Disclosed herein is a case for a portable electronic device. The case has a back wall and a plurality of side walls for retaining the portable electronic device. The back wall includes a storage area. A cover is hingedly attached to the back wall to selectively cover the storage area. The storage area includes a grip for retaining edges of data cards.

Abstract: The present application is directed to the intravitreal use of spherical nucleic acid (SNA) molecules in the treatment of eye disorders including dry-eye, retinal edema, retinopathy, macular degeneration and glaucoma among others. SNAs have a liposomal core with a plurality of oligonucleotides on the surface forming a shell, wherein the oligonucleotide preferably a TNF-alpha antisense oligonucleotide.

Abstract: Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.

Abstract: Aspects of the invention relate to compositions of spherical nucleic acids (SNAs) composed of a liposome or lipoplex complex having an oligonucleotide shell with CpG oligonucleotides positioned on the exterior of the liposome or lipoplex. The invention also relates to methods of treating subjects and of inducing cytokine expression in a subject using the compositions described herein.

Abstract: Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.

Abstract: Disclosed herein is a case for a portable electronic device. The case has a back wall and a plurality of side walls for retaining the portable electronic device. The back wall includes a storage area. A cover is hingedly attached to the back wall to selectively cover the storage area. The storage area includes a grip for retaining edges of data cards.

Abstract: Compositions related to spherical nucleic acids (SNAs) and structures with antisense oligonucleotides and methods of treatment of diseases and disorders are disclosed herein.

Abstract: Disclosed herein is an electronic device encasement which not only encases and protects the electronic device, it allows for storage and presentation of one or more data cards. As the encasement device operator initiates access to the stored data card by opening a protective storage cover, the accessing action initiates a subsequent mechanical response which presents the card by a separating action from the encasement and the other possible stored items, as to allow for easier access and use of the one or more data cards. The storage and presentment mechanisms include a plurality of pockets, grips, and other structures to secure and present the cards.

Abstract: TNF? antisense oligonucleotides are provided herein. Methods of treating TNF? diseases or disorders using the TNF? antisense oligonucleotides and related products are provided.

Abstract: Aspects of the invention relate to antisense oligonucleotides directed to the interleukin 17 receptor (IL-17R), and other targets. Spherical nucleic acid formulations or compositions of antisense oligonucleotides and related methods of treatment are also provided.

Abstract: The invention relates to a method of synthesizing liposomes and liposomal spherical nucleic acids with hydrophobic molecules functionalized to the surface. The lipid particles contain one or more agents that elicit an immune response.