Abstract: A suturing system including apparatus and methods for disposing stitches in a substrate comprising a thread carrier which inserts a thread in the substrate at a first location and withdraws the thread from the substrate at a second location.

Abstract: A system, method, and computer-program product includes obtaining an analytical request that specifies an analytical task to be performed using computing resources of an adaptive analytics compute service, determining, by the adaptive analytics compute service, an initial set of compute resources for executing the analytical request based on identifying a type of the analytical request, deploying, by the adaptive analytics compute service, a compute environment for executing the analytical request based on the initial set of compute resources, observing utilization data of the initial set of compute resources during a period of executing the analytical request within the compute environment, and commencing a machine learning-informed feedback sequence for autonomously adapting the compute environment, wherein one iteration of the machine learning-informed feedback sequence includes: generating a proposed set of compute resources, and encoding, based on the proposed set of compute resources, a set of instructi

Abstract: A suturing system including apparatus and methods for disposing stitches in a substrate comprising a thread carrier which inserts a thread in the substrate at a first location and withdraws the thread from the substrate at a second location.

Abstract: A method of facilitating control of a distributed energy resource which includes establishing, at a platform in communication over a network with the distributed energy resource, a first control access bundle of a first rank. The first control access bundle defines a first container including a first plurality of control events for controlling a distributed energy resource. A second control access bundle of a different, second rank is also established at the platform. The second control access bundle defines a second container including a second plurality of control events for controlling the distributed energy resource. Consolidated control events are generated from the first plurality of control events and the second plurality of control events, which may be of different priority. Events corresponding to the consolidated control events are sent to the distributed energy resource, the events controlling one or more parameters of the distributed energy resource.

Abstract: Provided are LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.

Abstract: A process, product, and system for detecting a defective vacuum in a packaged product. The process may include providing a packaged product including a product enclosed within a packaging article. The packaging article may include a film having at least one layer containing a fluorescence-based indicator. The process may further include exposing the packaged product to incident electromagnetic energy to produce an excited fluorescence-based indicator, such that the excited fluorescence-based indicator emits fluorescent electromagnetic energy; and determining, based on the fluorescent electromagnetic energy emitted by the excited fluorescence-based indicator, that gas is present within the packaging article.

Abstract: A method of facilitating control of a distributed energy resource which includes establishing, at a platform in communication over a network with the distributed energy resource, a first control access bundle of a first rank. The first control access bundle defines a first container including a first plurality of control events for controlling a distributed energy resource. A second control access bundle of a different, second rank is also established at the platform. The second control access bundle defines a second container including a second plurality of control events for controlling the distributed energy resource. Consolidated control events are generated from the first plurality of control events and the second plurality of control events, which may be of different priority. Events corresponding to the consolidated control events are sent to the distributed energy resource, the events controlling one or more parameters of the distributed energy resource.

Abstract: The present disclosure relates to antisense oligomers and related compositions and methods for inducing exon inclusion as a treatment for glycogen storage disease type II (GSD-II) (also known as Pompe disease, glycogenosis II, acid maltase deficiency (AMD), acid alpha-glucosidase deficiency, and lysosomal alpha-glucosidase deficiency), and more specifically relates to inducing inclusion of exon 2 and thereby restoring levels of enzymatically active acid alpha-glucosidase (GAA) protein encoded by the GAA gene.

Abstract: The present disclosure relates to antisense oligomers and related compositions and methods for decreasing the expression of functional human myostatin and methods for treating muscular dystrophy and related disorders and more specifically relates to inducing exclusion of myostatin exon 2 and thereby reducing levels of myostatin protein.

Abstract: The present disclosure relates to antisense oligomers and related compositions and methods for inducing exon inclusion as a treatment for glycogen storage disease type II (GSD-II) (also known as Pompe disease, glycogenosis II, acid maltase deficiency (AMD), acid alpha-glucosidase deficiency, and lysosomal alpha-glucosidase deficiency), and more specifically relates to inducing inclusion of exon 2 and thereby restoring levels of enzymatically active acid alpha-glucosidase (GAA) protein encoded by the GAA gene.

Abstract: A suturing system including apparatus and methods for disposing stitches in a substrate comprising a thread carrier which inserts a thread in the substrate at a first location and withdraws the thread from the substrate at a second location.

Abstract: A process, product, and system for detecting a defective vacuum in a packaged product. The process may include providing a packaged product including a product enclosed within a packaging article. The packaging article may include a film having at least one layer containing a fluorescence-based indicator. The process may further include exposing the packaged product to incident electromagnetic energy to produce an excited fluorescence-based indicator, such that the excited fluorescence-based indicator emits fluorescent electromagnetic energy; and determining, based on the fluorescent electromagnetic energy emitted by the excited fluorescence-based indicator, that gas is present within the packaging article.

Abstract: A suturing system including apparatus and methods for disposing stitches in a substrate comprising a thread carrier which inserts a thread in the substrate at a first location and withdraws the thread from the substrate at a second location.

Abstract: Provided are LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.

Abstract: Various embodiments provide methods in which a metal matrix composite (MMC) material is incorporated into a metallic structure during a one-step near-net-shape structural forming process. Various embodiments provide in-situ selective reinforcement processes in which the MMC may be pre-placed on a forming tool in locations that correspond to specific regions in the metallic structure. Various embodiment near-net-shape structural forming processes may then be executed and result in various embodiment metallic structural components with selectively-reinforced regions that provide enhanced mechanical properties in key locations.

Abstract: The present disclosure relates to antisense oligomers and related compositions and methods for decreasing the expression of functional human myostatin and methods for treating muscular dystrophy and related disorders and more specifically relates to inducing exclusion of myostatin exon 2 and thereby reducing the levels of myostatin protein.

Abstract: Provided are LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.