Patents by Inventor Richard Keith Humphries

Richard Keith Humphries has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microrna compositions and methods for the treatment of myelogenous leukemia
    Patent number: 8716255
    Abstract: The invention provides methods, uses, kits and compositions comprising a therapeutically effective amount of the microRNA miR-223 for treating myelogenous leukemia in a subject in need of such treatment. The invention further comprises methods encompassing the use of miR-223 for promoting the differentiation of a leukemia stem cell that is resistant to a differentiating agent, and a method of screening for candidate compounds capable of treating a myeloid leukemia by comparison of the therapeutic activity of the candidate compound with the therapeutic activity of miR-233.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: May 6, 2014
    Assignee: British Columbia Cancer Agency Branch
    Inventors: Florian Kuchenbauer, Michael Heuser, Richard Keith Humphries
  • STEM CELL EXPANSION ENHANCING FACTOR AND METHOD OF USE
    Publication number: 20110281786
    Abstract: The present invention relates to a stem cell expansion factor, and to a method for enhancing hematopoietic stem cell expansion by direct delivery of a protein in the cell and which protein is able to cross cell membrane. The method comprises directly delivering in a HSC an amino acid sequence having the activity of a peptide encoded by a Hoxb4 nucleotide sequence. Once delivered, the amino acid sequence is functionally active in the hematopoietic stem cell and enhances expansion thereof. The amino acid sequence may is a HOXB4 or HOXA4 protein.
    Type: Application
    Filed: July 26, 2011
    Publication date: November 17, 2011
    Inventors: Guy Sauvageau, Richard Keith Humphries
  • MICRORNA COMPOSITIONS AND METHODS FOR THE TREATMENT OF MYELOGENOUS LEUKEMIA
    Publication number: 20110244024
    Abstract: The invention provides methods, uses, kits and compositions comprising a therapeutically effective amount of the microRNA miR-223 for treating myelogenous leukemia in a subject in need of such treatment. The invention further comprises methods encompassing the use of miR-223 for promoting the differentiation of a leukemia stem cell that is resistant to a differentiating agent, and a method of screening for candidate compounds capable of treating a myeloid leukemia by comparison of the therapeutic activity of the candidate compound with the therapeutic activity of miR-233.
    Type: Application
    Filed: August 11, 2008
    Publication date: October 6, 2011
    Applicant: BRITISH COLUMBIA CANCER AGENCY BRANCH
    Inventors: Florian Kuchenbauer, Michael Heuser, Richard Keith Humphries
  • STEM CELL EXPANSION ENHANCING FACTOR AND METHOD OF USE
    Publication number: 20100080778
    Abstract: The present invention relates to a stem cell expansion factor, and to a method for enhancing hematopoietic stem cell expansion by direct delivery of a protein in the cell and which protein is able to cross cell membrane. The method comprises directly delivering in a HSC an amino acid sequence having the activity of a peptide encoded by a Hoxb4 nucleotide sequence. Once delivered, the amino acid sequence is functionally active in the hematopoietic stem cell and enhances expansion thereof. The amino acid sequence may is a HOXB4 or HOXA4 protein.
    Type: Application
    Filed: October 5, 2009
    Publication date: April 1, 2010
    Inventors: Guy Sauvageau, Richard Keith Humphries
  • Stem cell expansion enhancing factor and method of use
    Publication number: 20040082003
    Abstract: The present invention relates to a stem cell expansion factor, and to a method for enhancing hematopoietic stem cell expansion by direct delivery of a protein in the cell and which protein is able to cross cell membrane. The method comprises directly delivering in a HSC an amino acid sequence having the activity of a peptide encoded by a Hoxb4 nucleotide sequence. Once delivered, the amino acid sequence is functionally active in the hematopoietic stem cell and enhances expansion thereof. The amino acid sequence may is a HOXB4 or HOXA4 protein.
    Type: Application
    Filed: December 5, 2003
    Publication date: April 29, 2004
    Inventors: Guy Sauvageau, Richard Keith Humphries
  • Stem cell expansion enhancing factor and method of use
    Publication number: 20040072298
    Abstract: The present invention relates to a stem cell expansion factor, and to a method for enhancing hematopoietic stem cell expansion by direct delivery of a protein in the cell and which protein is able to cross cell membrane. The method comprises directly delivering in a HSC an amino acid sequence having the activity of a peptide encoded by a Hoxb4 nucleotide sequence. Once delivered, the amino acid sequence is functionally active in the hematopoietic stem cell and enhances expansion thereof. The amino acid sequence may consist of a HOXB4 protein.
    Type: Application
    Filed: October 8, 2003
    Publication date: April 15, 2004
    Inventors: Guy Sauvageau, Richard Keith Humphries
  • Hematopoietic stem cell expansion enhancing factor and method of use
    Publication number: 20020086383
    Abstract: The present invention relates to a hematopoietic stem cell expansion factor, and to a method for enhancing hematopoietic stem cell expansion by direct delivery of a protein in the cell. The method comprises directly delivering in a HSC an amino acid sequence having the activity of a peptide encoded by a Hoxb4 nucleotide sequence. Once delivered, the amino acid sequence is functionally active in the hematopoietic stem cell and enhances expansion thereof. The amino acid sequence may consist of a HOXB4 peptide.
    Type: Application
    Filed: February 20, 2001
    Publication date: July 4, 2002
    Inventors: Guy Sauvageau, Richard Keith Humphries