Patents by Inventor Richard Kho

Richard Kho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for determining polypeptide structure, function or pharmacophore from comparison of polypeptide sequences
    Patent number: 6792355
    Abstract: The invention provides a method for separating two or more subsets of polypeptides within a set of polypeptides. The method includes the steps of: (a) determining a sequence comparison signature for each amino acid sequence in a set of amino acid sequences, wherein the sequence comparison signature includes pairwise comparison scores for the amino acid sequence compared to each of the other amino acid sequences in the set; (b) constructing a distance arrangement including the sequence comparison signatures related according to the distance between each of the sequence comparison signatures; and (c) identifying a first and second cluster of sequence comparison signatures in the distance arrangement, wherein the first cluster includes sequence comparison signatures for polypeptides having a similar protein fold or biological function, the protein fold or function being different compared to a protein fold or function of polypeptides having sequence comparison signatures in the second cluster.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: September 14, 2004
    Assignee: Triad Therapeutics, Inc.
    Inventors: Mark R. Hansen, Richard Kho, Hugo O. Villar
  • Methods for determining polypeptide structure, function or pharmacophore from comparison of polypeptide sequences
    Publication number: 20030134326
    Abstract: The invention provides a method for separating two or more subsets of polypeptides within a set of polypeptides. The method includes the steps of: (a) determining a sequence comparison signature for each amino acid sequence in a set of amino acid sequences, wherein the sequence comparison signature includes pairwise comparison scores for the amino acid sequence compared to each of the other amino acid sequences in the set; (b) constructing a distance arrangement including the sequence comparison signatures related according to the distance between each of the sequence comparison signatures; and (c) identifying a first and second cluster of sequence comparison signatures in the distance arrangement, wherein the first cluster includes sequence comparison signatures for polypeptides having a similar protein fold or biological function, the protein fold or function being different compared to a protein fold or function of polypeptides having sequence comparison signatures in the second cluster.
    Type: Application
    Filed: December 21, 2001
    Publication date: July 17, 2003
    Inventors: Mark R. Hansen, Richard Kho, Hugo O. Villar