Patents by Inventor Richard Khoury

Richard Khoury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070275952
    Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
    Type: Application
    Filed: March 19, 2004
    Publication date: November 29, 2007
    Applicant: Exelixis, Inc.
    Inventors: Lynne Bannen, S. Brown, Wei Cheng, Vasu Jammalamadaka, John Nuss, Morrison Mac, Jason Parks, Matthew Williams, Wei Xu, Atwood Cheung, Lisa Dalrymple, Sergey Epshteyn, Mohamed Ibrahim, James Leahy, Gary Lewis, Robin Noguchi, Larry Mann, Brian Ridway, Joan Sangalang, Kevin Schnepp, Xian Shi, Richard Khoury
  • Publication number: 20070244116
    Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
    Type: Application
    Filed: May 24, 2007
    Publication date: October 18, 2007
    Applicant: EXELIXIS, INC.
    Inventors: LYNNE BANNEN, Diva Chan, Jeff Chen, Lisa Dalrymple, Timothy Forsyth, Tai Huynh, Vasu Jammalamadaka, Richard Khoury, James Leahy, Morrison Mac, Grace Mann, Larry Mann, John Nuss, Jason Parks, Craig Takeuchi, Yong Wang, Wei Xu
  • Publication number: 20070225307
    Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
    Type: Application
    Filed: May 24, 2007
    Publication date: September 27, 2007
    Applicant: EXELIXIS, INC.
    Inventors: Lynne Bannen, Diva Chan, Jeff Chen, Lisa Dalrymple, Timothy Forsyth, Tai Huynh, Vasu Jammalamadaka, Richard Khoury, James Leahy, Morrison Mac, Grace Mann, Larry Mann, John Nuss, Jason Parks, Craig Takeuchi, Yong Wang, Wie Xu
  • Publication number: 20070054928
    Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
    Type: Application
    Filed: October 26, 2006
    Publication date: March 8, 2007
    Applicant: EXELIXIS, INC.
    Inventors: Lynne Bannen, Diva Chan, Jeff Chen, Lisa Dalrymple, Timothy Forsyth, Tai Huynh, Vasu Jammalamadaka, Richard Khoury, James Leahy, Morrison Mac, Grace Mann, Larry Mann, John Nuss, Jason Parks, Craig Takeuchi, Yong Wang, Wei Xu
  • Publication number: 20070032515
    Abstract: The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as cancer, immunological disorders, cardiovascular diseases, and other degenerative disorders.
    Type: Application
    Filed: July 23, 2004
    Publication date: February 8, 2007
    Applicant: Exelixis, Inc.
    Inventors: Neel Anand, Charles Blazey, Owen Bowles, Joerg Bussenius, Simona Costanzo, Jeffry Curtis, Larisa Dubenko, Abigail Kennedy, Richard Khoury, Angie Kim, Jean-Claire Manalo, Csaba Peto, Kenneth Rice, Tsze Tsang
  • Publication number: 20060199820
    Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
    Type: Application
    Filed: June 11, 2003
    Publication date: September 7, 2006
    Inventors: Lynne Bannen, Erick Co, Vasu Jammalamadaka, John Nuss, Moon Hwan Kim, Donna Le, Amy Lew, Morrison Mac, Shumeye Mamo, Richard Khoury, Zhaoyang Wen, Wei Xu