Abstract: A microfluidic system comprising a chamber closed by movable elements and connected to at least one channel. The system has at least one structured component and at least one component attached to the structured component. The chamber is used such that the movable element can be moved into the chamber as well as out of the chamber by a movement of the movable element. Liquids or gases can be moved via one or more channels connected to the chamber by the movement and dispensed or received out of the structured component via a connection of the channel. A liquid reagent reservoir is connected to the pump chamber via the sample supply channel. Thus, the system can be used to receive, pump, dilute, mix, and dispense liquids or gases.

Abstract: The invention relates to a microfluidic device and to a method for use thereof for the separation, purification and concentration of components of fluid media. The invention relates in particular to a microfluidic device and a method for processing blood samples. A microfluidic device is provided, comprising: a structured component (1), which is formed as a flat body; a microfluidic channel system (2), which is configured in the structured component (1); at least one component (3) applied to a surface of the structured component (1); at least one porous functional element (5); and at least one fluidic interface (4.1, 4.2, 4.3), which is arranged at the structured component (1), for supplying media into the microfluidic channel system (2).

Abstract: A fluidic system includes a chamber with movable elements. The chamber is connected to a channel. The system contains at least one structured component and at least one element affixed thereto and at least one fluidic interface which can be closed by means of a cap or valve. Fluids or gases can be moved via one or more channels, and moreover can be dispensed from or taken into the system, by moving the movable element both into and out of the chamber. A fluids reagent reservoir can be connected to the pump chamber or the channel system for dilution purposes and also for supplying reaction components or scrubbing fluids. The system can be used for taking in, pumping, diluting, mixing and dispensing fluids or gases.

Abstract: The invention relates to a fluidic system comprising a chamber which is closed by movable elements and which is connected to at least one channel. The entire system has at least one structured component, at least one component which is attached to the structured component, and a component for storing liquids. The invention additionally relates to a closure option for at least one fluidic interface. The closure option can be configured as a cap or a valve. The invention has at least two fluidic interfaces. The chamber is used such that the movable element can be moved into the chamber as well as out of the chamber by a movement of the movable element. Liquids or gases can be moved via one or more channels connected to the chamber by means of the movement and dispensed or received out of the structured component via a connection of the channel. A liquid reagent reservoir is connected to the pump chamber via the sample supply channel.

Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Abstract: The present invention describes a device consisting of a rotor, a holding-down device, and a base plate. The base plate is normally a fluidic system, a planar fluidic system for example or a fluidic system with several fluidic ports for a directed guidance of liquids or gases through different channels, channel systems, cavities or tubing, for the combination liquid and gas streams, or for prevention of liquid flows.

Abstract: A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.

Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Abstract: A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.

Abstract: An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.

Abstract: The present invention describes a device consisting of a rotor, a holding-down device, and a base plate. The base plate is normally a fluidic system, a planar fluidic system for example or a fluidic system with several fluidic ports for a directed guidance of liquids or gases through different channels, channel systems, cavities or tubing, for the combination liquid and gas streams, or for prevention of liquid flows.

Abstract: A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.

Abstract: A microneedle applicator is provided which has two roughly concentric portions which may be, for example, a solid disk and an annulus surrounding it. On the skin-facing side of the inner portion of the applicator a microneedle array is located. The outer portion of the applicator is placed against the skin, contacting it at a zone. The microneedle array is then pressed towards the skin.

Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Abstract: An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.

Abstract: A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.