Abstract: Provided herein are settable and non-settable compositions for use in surgical procedures comprising a variety of disclosed particles and optionally including previously unclotted, lyophilized, optionally crosslinked mammalian blood plasma. Also provided are related compositions, including surgical kits and packages, as well as methods of making and using the compositions.

Abstract: Provided herein are settable and non-settable compositions for use in surgical procedures comprising a variety of disclosed particles and optionally including previously unclotted, lyophilized, optionally crosslinked mammalian blood plasma. Also provided are related compositions, including surgical kits and packages, as well as methods of making and using the compositions.

Abstract: Provided herein are settable and non-settable compositions for use in surgical procedures comprising a variety of disclosed particles and optionally including previously unclotted, lyophilized, optionally crosslinked mammalian blood plasma. Also provided are related compositions, including surgical kits and packages, as well as methods of making and using the compositions.

Abstract: At least three component, body-implantable, absorbable, biocompatible, putty, and non-putty pain-relieving compositions for use in surgery comprising in intimate admixture: an analgesic having local pain-relieving activity for internal relief of pain, a finely powdered bulking material, preferably less than 50 microns, e.g. the metal salts of fatty acid, hydroxyapatite, DBM, polyglycolide, polylactide, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches. An organic liquid capable of solubilizing, dispensing or suspending the analgesic, such as esters of monohydric alcohols with aliphatic monocarboxylic acids; C2-C18 monohydric alcohols with polycarboxylic acids; C8-C30 monohydric alcohols; tocopherol and esters thereof with mono or polycarboxylic acids; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; polyhydroxy compounds and esters and ethers thereof; random or block copolymers of ethylene oxide and propylene oxide.

Abstract: Two (or more), -component, body-implantable, absorbable, biocompatible, putty, and non-putty hemostatic tamponades for use in surgery. Component 1 is a finely powdered bulking material, preferably less than 50 microns, e.g. the calcium, magnesium, aluminum, or barium salts of saturated or unsaturated carboxylic acids containing about 6 to 22 carbon atoms, hydroxyapatite, DBM, polyglycolide, polylactide, poldioxinones, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches.

Abstract: Two (or more), component, body-implantable, absorbable, biocompatible, putty-like surgical mechanical hemostatic tamponades for use in surgery. Component 1, a carboxylic acid salt bulking material preferably less than 50 micron, preferably the calcium, magnesium, zinc, aluminum, lithium or barium salts of saturated or unsaturated carboxylic acids containing about 6 to 22 carbon atoms. Component 2, a dispersing vehicle, may be esters of C8-C18 monohydric alcohols with C2-C6 aliphatic monocarboxylic acids; C2-C18 monohydric alcohols with polycarboxylic acids; C8-C30 monohydric alcohols; tocopherol and esters thereof with C2-C10 aliphatic monocarboxylic acids or polycarboxylic acids; absorbable 10-14C hydrocarbons; free carboxylic acids such as oleic, linoleic, caprylic, capric, and lauric; dialkyl ethers; alkyl aryl ethers; dialkyl ketones and alkyl aryl ketones; polyhydroxy compounds and esters and ethers thereof; oils such as olive oil and castor oil and triglycerides.

Abstract: This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.

Abstract: Two (or more), -component, body-implantable, absorbable, biocompatible, putty, and non-putty hemostatic tamponades for use in surgery. Component 1 is a finely powdered bulking material, preferably less than 50 microns, e.g. the calcium, magnesium, aluminum, or barium salts of saturated or unsaturated carboxylic acids containing about 6 to 22 carbon atoms, hydroxyapatite, DBM, polyglycolide, polylactide, poldioxinones, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches.

Abstract: This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices.

Abstract: Disclosed are compositions and methods for the facile perfusion of a tissue with active agents following direct intra-tissue injection. Targets may consist of cells, cellular components, and/or extracellular components. The high perfusion efficiency permits high concentrations of active agents to be delivered to tissue targets resulting in high degrees of efficacy and in some instances the production of novel pharmacological activities of an active agent previously unknown or previously unattainable in vivo.

Abstract: A bioreactor is described comprising: at least one cartridge having disposed therein at least one collagen substrate comprised of a collagen sponge layer and a nonporous to cells, semipermeable collagen layer; a substrate support that retains the collagen substrate within the cartridge; a first compartment between the collagen sponge layer and the inner surface of the first side of the cartridge casing and a second compartment between the nonporous to cells, semipermeable collagen layer and the inner surface of the second side of the cartridge casing; inlet and outlet means for transferring a first medium and a first cell type to the first compartment and inlet and outlet means for transferring a second medium and a second cell type to the second compartment.

Abstract: In a method and apparatus for delivering a composition to a targeted area of tissue, exposure of a non-targeted tissue to the composition is minimized. The apparatus has at least one needle-like shaft which is inserted through a track in the non-targeted tissue to deliver the composition to the targeted tissue through an opening in the shaft. The track may be a naturally occurring lumen in a tissue, such as a vascular lumen, or may be a track created surgically by a diagnostic instrument, or by the needle-like shaft of the present apparatus. A valve-like mechanism closes the opening in the shaft to prevent premature delivery of the composition during insertion of the shaft, and to prevent loss of composition during withdrawal of the shaft. The valve-like mechanism also prevents excessive delivery of the composition to targeted tissue. An annular dam is mounted on an exterior portion of the shaft near the opening.

Abstract: In a method and apparatus for delivering a composition to a targeted area of tissue, exposure of a non-targeted tissue to the composition is minimized. The apparatus has at least one needle-like shaft which is inserted through a track in the non-targeted tissue to deliver the composition to the targeted tissue through an opening in the shaft. The track may be a naturally occurring lumen in a tissue, such as a vascular lumen, or may be a track created surgically by a diagnostic instrument, or by the needle-like shaft of the present apparatus. A valve-like mechanism closes the opening in the shaft to prevent premature delivery of the composition during insertion of the shaft, and to prevent loss of composition during withdrawal of the shaft. The valve-like mechanism also prevents excessive delivery of the composition to targeted tissue. An annular dam is mounted on an exterior portion of the shaft near the opening.