Patents by Inventor RICHARD KUO-AN TSAI

RICHARD KUO-AN TSAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protection of virus particles from phagocytosis by expression of CD47
    Patent number: 9050269
    Abstract: The present invention relates to a viral particle. The viral particle has a radius of less than about 1 ?m, and at least one peptide comprising at least a biologically active portion of CD47. The present invention also includes a method of increasing the life of a particle in vivo in a mammal. The method includes the steps of expressing at least one peptide comprising at least a biologically active portion of CD47 in a viral particle, and administering the viral particle having CD47 expressed to a mammal, wherein the administered viral particle has a longer half life in the mammal than an otherwise identical viral particle that does not have CD47 expressed thereon.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: June 9, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Dennis E. Discher, Richard Kuo-An Tsai
  • Protection of Virus from Immune Cell Uptake
    Publication number: 20100316570
    Abstract: The present invention relates to a viral particle. The viral particle has a radius of less than about 1 ?m, and at least one peptide comprising at least a biologically active portion of CD47. The present invention also includes a method of increasing the life of a particle in vivo in a mammal. The method includes the steps of expressing at least one peptide comprising at least a biologically active portion of CD47 in a viral particle, and administering the viral particle having CD47 expressed to a mammal, wherein the administered viral particle has a longer half life in the mammal than an otherwise identical viral particle that does not have CD47 expressed thereon.
    Type: Application
    Filed: March 10, 2010
    Publication date: December 16, 2010
    Inventors: DENNIS E. DISCHER, RICHARD KUO-AN TSAI