Patents by Inventor Richard L. Beard

Richard L. Beard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaromatic compounds having sphingosine-1-phosphate (S1P) receptor agonist biological activity
    Patent number: 7728014
    Abstract: A novel compound having agonist activity at the S1P3 receptor which is represented by the formula I wherein X is selected from the group consisting of CR3, N and NO; Y is selected from the group consisting of CR3, N and NO; Z is selected from the group consisting of CR3, N and NO; and at least one of X, Y and Z is N or NO; V is O or NOR4 R1 is an aryl group; R2 is an aryl group; R3 is selected from the group consisting of H and alkyl; and 2 of said R3 groups may together form a cyclic alkyl ring having from 3 to 6 carbon atoms; R4 is selected from the group consisting of H and alkyl; a is 0 or an integer of from 1 to 6; b is 0 or 1; c is 0 or 1; f is 0 or an integer of 1 or 2; x is 0 or 1; y is 0 or an integer of from 1 to 3; and z is 0 or an integer of from 1 to 3.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: June 1, 2010
    Assignee: Allergan, Inc.
    Inventors: Richard L. Beard, John E. Donello, Haiqing Yuan, Xiaoxia Liu
  • THERAPEUTICALLY USEFUL SUBSTITUTED HYDROPYRIDO [3,2,1-ij] QUINOLINE COMPOUNDS
    Publication number: 20100009985
    Abstract: Disclosed herein are compounds represented by the structural formula: therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Application
    Filed: May 7, 2009
    Publication date: January 14, 2010
    Applicant: ALLERGAN, INC.
    Inventors: Santosh C. SINHA, Smita S. BHAT, Ken CHOW, Richard L. BEARD, John E. DONELLO, Michael E. GARST
  • BICYCLIC COMPOUNDS HAVING ACTIVITY AT THE CXCR4 RECEPTOR
    Publication number: 20090312305
    Abstract: A compound represented by the structural formula: Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Application
    Filed: May 18, 2009
    Publication date: December 17, 2009
    Applicant: ALLERGAN, INC.
    Inventors: Richard L. Beard, Tien T. Duong, Thong H. Vu, Vidyasagar Voligonda, John E. Donello, Michael E. Garst, Gerard A. Rodrigues
  • THERAPEUTICALLY USEFUL SUBSTITUTED 1,7-DIPHENYL-1,2,3,5,6,7-HEXAHYDROPYRIDO[3,2,1-Ij]QUINOLINE COMPOUNDS
    Publication number: 20090281322
    Abstract: Disclosed herein are compounds represented by the structural formula: Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Application
    Filed: May 1, 2009
    Publication date: November 12, 2009
    Applicant: ALLERGAN, INC.
    Inventors: Santosh C. Sinha, Smita S. Bhat, Ken Chow, Richard L. Beard, John E. Donello
  • Combination Insulating Beverage Holder and Headgear
    Publication number: 20090205111
    Abstract: Insulating beverage holder that can be fitted and carried inside a baseball cap. The insulating holder has a body made of a sheet of insulative fabric, with fasteners along fabric sides of the body. Fasteners are zip-lock strips or touch-fastener strips. The body is folded together and the sides fastened together to form a cup. The body, when opened out, fits inside a conventional baseball cap. The upper edges of the body can be tucked behind a finish edge on the cap, to hold the insulating holder body in place, even when the cap is removed from the head. The insulating holder may incorporate a strap for holding a bottle opener. The beverage holder may also be mounted on the outside surface of the baseball cap. Mating fastener strips are provided on the outside surface, which allow the body to be easily attached to or removed from the cap.
    Type: Application
    Filed: February 15, 2008
    Publication date: August 20, 2009
    Inventor: Richard L. Beard
  • UNIFIED USER INPUT DEVICE
    Publication number: 20090040077
    Abstract: A unified user input device is provided. The input device may include keys normally provided as part of a general purpose alphanumeric computer keyboard. In addition, a positional controller is provided. Both the conventional alphanumeric keys and the positional controller are associated with the same device platform. Additionally, special function keys may also be provided in association with the positional controller. Signals encoding the selection of an alphanumeric key, a control input, or a special function key are communicated to an interconnected computer using a common, conventional keyboard connection, and a common signaling protocol.
    Type: Application
    Filed: September 22, 2008
    Publication date: February 12, 2009
    Inventors: Mark E. Repetto, Gregory M. Danaha, Richard L. Beard
  • Bottle Opener
    Publication number: 20080173135
    Abstract: Bottle opener having two through-slots that allow it to be threaded onto a strap, such as the adjustment strap of a baseball cap or a strap loop on a beverage cooler. The bottle opener may include additional features, such as a retainer or magnet for a golf ball marker, another magnet to prevent a removed bottle cap from falling to the ground. A small instrument, such as a compass, a watch, or a temperature indicator, may be mounted on the bottle opener.
    Type: Application
    Filed: May 16, 2007
    Publication date: July 24, 2008
    Inventor: Richard L. Beard
  • 6-SUBSTITUTED INDOLE-3-CARBOXYLIC ACID AMIDE COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY
    Publication number: 20080171772
    Abstract: The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity: and wherein the variables Y, R4, n, o, A, A1, A2, X, Z, R1, R3, R2, p, q and r are as defined in the specification.
    Type: Application
    Filed: January 11, 2008
    Publication date: July 17, 2008
    Inventors: Richard L. Beard, Haiging Yuan, John E. Donello, Xiaoxia Liu, Tien Duong
  • HETEROAROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR AGONIST BIOLOGICAL ACTIVITY
    Publication number: 20080064872
    Abstract: A novel compound having agonist activity at the S1P3 receptor which is represented by the formula I wherein X is selected from the group consisting of CR3, N and NO; Y is selected from the group consisting of CR3, N and NO; Z is selected from the group consisting of CR3, N and NO; and at least one of X, Y and Z is N or NO; V is O or NOR4 R1 is an aryl group; R2 is an aryl group; R3 is selected from the group consisting of H and alkyl; and 2 of said R3 groups may together form a cyclic alkyl ring having from 3 to 6 carbon atoms; R4 is selected from the group consisting of H and alkyl; a is 0 or an integer of from 1 to 6; b is 0 or 1; c is 0 or 1; f is 0 or an integer of 1 or 2; x is 0 or 1; y is 0 or an integer of from 1 to 3; and z is 0 or an integer of from 1 to 3.
    Type: Application
    Filed: September 6, 2007
    Publication date: March 13, 2008
    Inventors: Richard L. Beard, John E. Donello, Haiqing Yuan, Xiaoxia Liu
  • Indole Compounds having sphingosine-1-phosphate (S1P) receptor antagonist
    Publication number: 20070232682
    Abstract: The present invention provides novel compounds having the following general formula I wherein: A, B, X, Y, R1, R2, R3, R4, n, o and p are as defined in the specification. Such compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions or diseases and wound healing.
    Type: Application
    Filed: March 23, 2007
    Publication date: October 4, 2007
    Applicant: ALLERGAN, INC.
    Inventors: Richard L. Beard, John E. Donello, Haiqing Yuan, Vidyasagar Vuligonda, Tien T. Duong
  • INDOLE-3-CARBOXYLIC ACID AMIDE, ESTER, THIOAMIDE AND THIOL ESTER COMPOUNDS BEARING ARYL OR HETEROARYL GROUPS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY
    Publication number: 20070191313
    Abstract: The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity: and wherein the variables Y, R4, n, A, X, Z, R1, o, R3, R2 and p are as defined in the specification.
    Type: Application
    Filed: February 15, 2007
    Publication date: August 16, 2007
    Inventors: Richard L. Beard, John E. Donello, Haiqing Yuan, Diana F. Colon, Tien Duong, Xiaoxia Liu, Yihui Hu
  • Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, a pyridyl group and an alkyl group, having retinoid-like biological activity
    Patent number: 7026487
    Abstract: Compounds of the formula where the symbols are as defined in the specification, have retinoid agonist, antagonist or negative hormone-like biological activity.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: April 11, 2006
    Assignee: Allergan, Inc.
    Inventors: Richard L. Beard, Thong Vu, Diana F. Colon, Vidyasagar Vuligonda, Roshantha A. Chandraratna
  • Compositions and methods for reducing serum glucose and triglyceride levels in diabetic mammals
    Patent number: 7019034
    Abstract: Diabetic mammals are treated with compounds that are significantly more efficacious as agonists of RXR? retinoid receptors than as agonists of RXR? or RXR? retinoid receptors. The treatment reduces serum glucose and triglyceride levels of the mammals without the undesirable side effects of reducing serum thyroxine levels and a transient increase in serum triglyceride levels Compounds suitable for use in the methods of treatments of the present invention are selected by testing and identifying compounds of selective or specific efficacy as agonists of RXR? retinoid receptors in preference over RXR? and/or RXR? retinoid receptors. Novel compounds used in the methods of the invention have Formula 1 where the variables are defined as disclosed in the specification.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: March 28, 2006
    Assignee: Allergan, Inc.
    Inventors: Yang-Dar Yuan, Richard L. Beard, Roshantha A. Chandraratna
  • Methods for modulating FXR receptor activity
    Patent number: 6906057
    Abstract: Methods for modulating the activity of the mammalian FXR receptor. The methods include methods of treating a hyper- or hypocholesterolemic mammal comprising contacting the mammal with synthetic compounds having FXR receptor activity.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: June 14, 2005
    Assignees: Allergan, Inc., City of Hope National Medical Center
    Inventors: Barry M. Forman, Richard L. Beard, Roshantha A. Chandraratna
  • TREATMENT OF TUMORS WITH ACETYLENES DISUBSTITUTED WITH A PHENYL OR HETEROAROMATIC GROUP AND A SUBSTITUTED CHROMANYL, THIOCHROMANYL OR TETRAHYDROQUINOLINYL GROUP IN COMBINATION WITH OTHER ANTI-TUMOR AGENTS
    Patent number: 6903121
    Abstract: Compounds of Formula 1 Formula 1 where the symbols have the meaning described in the specification, and particularly the compound of Formula 3 Formula 3 (tazarotene) exhibit synergistic anti-proliferative effect with human recombinant interferon in the treatment of solid tumors and leukemia, particularly breast cancer and acute myeloid leukemia.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: June 7, 2005
    Assignee: Allergan, Inc.
    Inventors: Alissar Nehme, Richard L. Beard, Roshantha A. Chandraratna
  • 7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity
    Patent number: 6887896
    Abstract: Compounds of the formula where the variations have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of transiently increasing triglyceride levels and reducing serum thyroxine levels.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: May 3, 2005
    Assignee: Allergan, Inc.
    Inventors: Richard L. Beard, Tien T. Duong, Janet A. Takeuchi, Ling Li, Kwok Yin Tsang, Xiaoxia Liu, Jayasree Vasudevan, Liming Wang, Santosh C. Sinha, Haiqing Yuan, Roshantha A. Chandraratna
  • 5,6,7,8-tetrahydronaphthalen-2-yl-7-fluoroalkyl-heptatrienoic acid derivatives having serum glucose reducing activity
    Patent number: 6884820
    Abstract: Compounds of the formula where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effect of reducing serum thyroxine levels.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: April 26, 2005
    Assignee: Allergan, Inc.
    Inventors: Richard L. Beard, Haiqing Yuan, Roshantha A. Chandratratna
  • O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
    Patent number: 6855832
    Abstract: Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: February 15, 2005
    Assignee: Allergan, Inc.
    Inventors: Vidyasagar Vuligonda, Min Teng, Richard L. Beard, Alan T. Johnson, Yuan Lin, Roshantha A. Chandraratna
  • Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
    Patent number: 6818775
    Abstract: Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: November 16, 2004
    Assignee: Allergan, Inc.
    Inventors: Alan T. Johnson, Min Teng, Vidyasagar Vuligonda, Richard L. Beard, Samuel J. Gillett, Tien T. Duong, Roshantha A. Chandraratna
  • Divot tool
    Patent number: D567319
    Type: Grant
    Filed: January 19, 2007
    Date of Patent: April 22, 2008
    Inventor: Richard L. Beard