Patents by Inventor Richard L. Gehant

Richard L. Gehant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for protein extraction
    Patent number: 8940875
    Abstract: The invention includes a process for extracting a target protein from Escherichia coli cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: January 27, 2015
    Assignee: Genentech, Inc.
    Inventor: Richard L. Gehant
  • PROCESS FOR PROTEIN EXTRACTION
    Publication number: 20130172535
    Abstract: The invention includes a process for extracting a target protein from E. coli cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
    Type: Application
    Filed: June 29, 2012
    Publication date: July 4, 2013
    Inventor: Richard L. Gehant
  • Protein product and method for reducing biomass-biomass interactions
    Patent number: 8383773
    Abstract: The invention includes a process for extracting a target protein from Escherichia coli (E. coli) cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: February 26, 2013
    Assignee: Genentech, Inc.
    Inventor: Richard L. Gehant
  • Method for decreasing biomass-biomass interactions or biomass-resin interactions
    Patent number: 8232374
    Abstract: The invention includes a process for extracting a heterologous target protein from Escherichia coli (E. coli) cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: July 31, 2012
    Assignee: Genentech, Inc.
    Inventor: Richard L. Gehant
  • PROCESS FOR PROTEIN EXTRACTION
    Publication number: 20110124845
    Abstract: The invention includes a process for extracting a target protein from E. coli cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
    Type: Application
    Filed: May 10, 2010
    Publication date: May 26, 2011
    Inventor: Richard L. Gehant
  • PROCESS FOR PROTEIN EXTRACTION
    Publication number: 20100222558
    Abstract: The invention includes a process for extracting a target protein from E. coli cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
    Type: Application
    Filed: January 26, 2010
    Publication date: September 2, 2010
    Inventor: Richard L. GEHANT
  • Process for protein extraction
    Patent number: 7713707
    Abstract: The invention includes a process for extracting a target protein from Escherichia coli cells that includes lowering the pH of a whole Escherichia coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: May 11, 2010
    Assignee: Genentech, Inc.
    Inventor: Richard L. Gehant
  • Process for reducing biomass-biomass or biomass—resin interactions
    Patent number: 7662934
    Abstract: The invention includes a process for extracting a target protein from E. coli cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: February 16, 2010
    Assignee: Genentech, Inc.
    Inventor: Richard L. Gehant
  • Process for protein extraction
    Patent number: 6967241
    Abstract: The invention includes a process for extracting a target protein from E. coli cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: November 22, 2005
    Assignee: Genentech, Inc.
    Inventor: Richard L. Gehant
  • Process for protein extraction
    Publication number: 20040049012
    Abstract: The invention includes a process for extracting a target protein from E. coli cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
    Type: Application
    Filed: September 5, 2003
    Publication date: March 11, 2004
    Applicant: Genentech, Inc.
    Inventor: Richard L. Gehant