Patents by Inventor Richard L. Krebs

Richard L. Krebs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8771727
    Abstract: This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions containing an antigen combined with such emulsions intrinsically or extrinsically. Methods of preparing the emulsions and vaccines are also provided by the present invention.
    Type: Grant
    Filed: December 31, 2009
    Date of Patent: July 8, 2014
    Assignee: Zoetis LLC
    Inventors: Paul J. Dominowski, Ramasamy M. Mannan, Richard L. Krebs, Pamela K. Klose
  • Patent number: 8580280
    Abstract: This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
    Type: Grant
    Filed: June 24, 2009
    Date of Patent: November 12, 2013
    Assignee: Zoetis LLC
    Inventors: Paul J. Dominowski, Ramasamy M. Mannan, Richard L. Krebs, James R. Thompson, Tedd A. Childers, Mary K. Olsen, Robert J. Yancey, Jr., Risini Weeratna, Shucheng Zhang, Cedo M. Bagi
  • Publication number: 20100173854
    Abstract: This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions containing an antigen combined with such emulsions intrinsically or extrinsically. Methods of preparing the emulsions and vaccines are also provided by the present invention.
    Type: Application
    Filed: December 31, 2009
    Publication date: July 8, 2010
    Applicant: PHARMACIA & UPJOHN COMPANY LLC
    Inventors: Paul J. Dominowski, Pamela Klose, Richard L. Krebs, Ramasamy Mannan
  • Patent number: 7736658
    Abstract: This invention relates to vaccines and methods for protecting dogs against disease caused by Bordetella bronchiseptica. This invention also relates to combination vaccines and methods for protecting dogs against disease or disorder caused by canine pathogens, for example, infectious tracheobronchitis caused by Bordetella bronchiseptica, canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, enteritis caused by canine coronavirus (CCV) and canine parvovirus (CPV), and leptospirosis caused by Leptospira Bratislava, Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae or Leptospira pomona. The vaccines of the present invention include a Bordetella bronchiseptica p68 antigen.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: June 15, 2010
    Assignee: Pfizer Inc.
    Inventors: Paul J. Dominowski, Joseph C. Frantz, Richard L. Krebs, Shelly L. Shields, Robert Greg Sorensen
  • Publication number: 20090324641
    Abstract: This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
    Type: Application
    Filed: June 24, 2009
    Publication date: December 31, 2009
    Applicant: PFIZER INC.
    Inventors: Paul J. Dominowski, Ramasamy M. Mannan, Richard L. Krebs, James R. Thompson, Tedd A. Childers, Mary K. Olsen, Robert J. Yancey, Jr., Risini Weeratna, Shucheng Zhang, Cedo M. Bagi
  • Publication number: 20080226670
    Abstract: This invention relates to vaccines and methods for protecting dogs against disease caused by Bordetella bronchiseptica. This invention also relates to combination vaccines and methods for protecting dogs against disease or disorder caused by canine pathogens, for example, infectious tracheobronchitis caused by Bordetella bronchiseptica, canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, enteritis caused by canine coronavirus (CCV) and canine parvovirus (CPV), and leptospirosis caused by Leptospira Bratislava, Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae or Leptospira pomona. The vaccines of the present invention include a Bordetella bronchiseptica p68 antigen.
    Type: Application
    Filed: November 20, 2007
    Publication date: September 18, 2008
    Applicants: WARNER-LAMBERT COMPANY, PFIZER INC.
    Inventors: Paul J. Dominowski, Joseph C. Frantz, Richard L. Krebs, Shelly L. Shields, Robert Greg Sorensen
  • Patent number: 7122191
    Abstract: This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions containing an antigen combined with such emulsions intrinsically or extrinsically. Methods of preparing the emulsions and vaccines are also provided by the present invention.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: October 17, 2006
    Assignee: Pfizer Inc.
    Inventors: Paul Joseph Dominowski, Pamela K. Klose, Richard L. Krebs, Ramasamy M. Mannan
  • Publication number: 20040258701
    Abstract: This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions containing an antigen combined with such emulsions intrinsically or extrinsically. Methods of preparing the emulsions and vaccines are also provided by the present invention.
    Type: Application
    Filed: April 5, 2004
    Publication date: December 23, 2004
    Applicants: PFIZER INC., PFIZER PRODUCTS INC.
    Inventors: Paul J. Dominowski, Pamela Klose, Richard L. Krebs, Ramasamy Mannan
  • Publication number: 20040185062
    Abstract: This invention relates to vaccines and methods for protecting dogs against disease caused by Bordetella bronchiseptica. This invention also relates to combination vaccines and methods for protecting dogs against disease or disorder caused by canine pathogens, for example, infectious tracheobronchitis caused by Bordetella bronchiseptica, canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, enteritis caused by canine coronavirus (CCV) and canine parvovirus (CPV), and leptospirosis caused by Leptospira Bratislava, Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae or Leptospira pomona. The vaccines of the present invention include a Bordetella bronchiseptica p68 antigen.
    Type: Application
    Filed: January 29, 2004
    Publication date: September 23, 2004
    Inventors: Paul J. Dominowski, Joseph C. Frantz, Richard L. Krebs, Shelly L. Shields, Robert Greg Sorensen