Patents by Inventor Richard L. Littenberg

Richard L. Littenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic compositions against gastrin peptides
    Patent number: 6861510
    Abstract: Immmunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 1, 2005
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Method for the treatment and prevention of gastric and duodenal ulcer
    Patent number: 5866128
    Abstract: Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 2, 1999
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg
  • Method of the treatment of gastrointestinal disorders with immunogenic compositions against gastrin
    Patent number: 5785970
    Abstract: Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: July 28, 1998
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
    Patent number: 5622702
    Abstract: Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: April 22, 1997
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg
  • Methods for the preparation of immunogens against gastrin
    Patent number: 5609870
    Abstract: Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: March 11, 1997
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Immunogenic compositions against gastrin peptides
    Patent number: 5607676
    Abstract: Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: March 4, 1997
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
    Patent number: 5023077
    Abstract: Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
    Type: Grant
    Filed: January 24, 1989
    Date of Patent: June 11, 1991
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg