Patents by Inventor Richard L. Wahl

Richard L. Wahl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10385220
    Abstract: Systems and method for forming a nanocomposite material. One example of a nanocomposite material includes a first sulfur-based nanoparticle material defining a first nanophase and a second sulfur-based nanoparticle material defining a second nanophase, wherein the nanocomposite material is at least partially long-wave infrared (LWIR) transmitting, and the first nanophase and the second nanophase are co-dispersed to form interpenetrating networks with one another and each has a grain structure that is distinct from one another.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: August 20, 2019
    Assignee: RAYTHEON COMPANY
    Inventors: Joseph M. Wahl, Richard L. Gentilman, Randal W. Tustison, Christopher S. Nordahl, Huy Q. Nguyen, Ralph Korenstein
  • Patent number: 9171369
    Abstract: An embodiment of the current invention includes computer-implemented method for image processing. The method includes receiving a first medical image from a data storage device, the first medical image comprising a plurality of image voxels and representing a plurality of tissue regions of a subject; automatically determining a reference value based on the first medical image, the reference value capable of providing a range of background level of voxel intensity values within at least one non-disease tissue region of the subject; generating a disease threshold based on the reference value; identifying portions of the medical image corresponding to disease-tissue regions according to the disease threshold, each of the portions comprising a plurality of connected image voxels in the medical image; and entering data encoding the disease-tissue regions into a database for subsequent comparisons.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: October 27, 2015
    Assignee: The Johns Hopkins University
    Inventors: Jeffrey Leal, Richard L. Wahl
  • Publication number: 20150286796
    Abstract: A method and system of treating a disease for a patient, comprising assigning class data related to a class of patients that have characteristics similar to a specific patient and/or accessing patent data related to the specific patient; and optimizing a treatment plan, the optimizing being determined utilizing properties of a radio-pharmaceutical used to treat the patient and the class data and/or the patient data.
    Type: Application
    Filed: October 25, 2013
    Publication date: October 8, 2015
    Inventors: Robert Hobbs, George Sgouros, Richard L. Wahl
  • Publication number: 20130208963
    Abstract: An embodiment of the current invention includes computer-implemented method for image processing. The method includes receiving a first medical image from a data storage device, the first medical image comprising a plurality of image voxels and representing a plurality of tissue regions of a subject; automatically determining a reference value based on the first medical image, the reference value capable of providing a range of background level of voxel intensity values within at least one non-disease tissue region of the subject; generating a disease threshold based on the reference value; identifying portions of the medical image corresponding to disease-tissue regions according to the disease threshold, each of the portions comprising a plurality of connected image voxels in the medical image; and entering data encoding the disease-tissue regions into a database for subsequent comparisons.
    Type: Application
    Filed: October 26, 2011
    Publication date: August 15, 2013
    Applicant: The Johns Hopkins University
    Inventors: Jeffrey Leal, Richard L. Wahl
  • Patent number: 7672712
    Abstract: A device for visualizing structure located on the interior of a biological substance. The device includes a marker member that may be a solid cylinder or lumen having an interior volume having a distal end removably insertable in the biological substance relative to the interior structure to be visualized. An image-enhancing material is contained relative to the marker member in a manner such that the imaging material does not directly contact the biological substance. The imaging material of choice is one capable of producing an emission or signal detectable external to the biological substance by suitable imaging instrumentation. Also disclosed is a method for visualizing critical structures or radiation therapy targets in imaging processes such as positron emission tomography and/or single photon emission computerized tomography, MRI, or ultrasound either used alone or in combination or in registration with anatomical imaging processes such as computed tomography or mammography.
    Type: Grant
    Filed: July 22, 2003
    Date of Patent: March 2, 2010
    Assignee: The Regents of The University of Michigan
    Inventors: Cherry T. Thomas, Richard L. Wahl, Susan J. Fisher
  • Patent number: 7668662
    Abstract: A patient-specific optimally effective radiation dose for administration of a radiopharmaceutical to a patient for treatment of a disease may be established by basing the calculation of the appropriate therapeutic dose on factors such as the desired total body dose, the maximum tolerated dose, the typical clearance profile of the radiopharmaceutical, the patient's mass or maximum effective mass, and the patient-specific residence time of the radiopharmaceutical or an analog in the whole body of the patient. The use of the method allows for treatment of a patient with an appropriate dose which is maximally effective against the disease yet minimally toxic. The determination of a patient-specific therapeutic dose may be assisted by the use of a software program set to the particular parameters of the radiopharmaceutical.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: February 23, 2010
    Assignees: The Regents of the University of Michigan, Smithkline Beecham Corporation
    Inventors: Stewart M. Kroll, Jeffry A. Siegal, Richard L. Wahl, Kenneth R. Zasadny
  • Patent number: 6628982
    Abstract: The present invention is directed to a device for visualizing structure located on the interior of a biological substance. The device of the present invention includes a marker member which may be a solid cylinder or lumen having an interior volume. The marker member has a proximal end, and a distal end. The distal end of the device is removably insertable in the biological substance relative to the interior structure to be visualized and is composed of a biologically stable substrate material. An image-enhancing material is contained relative to the marker member in a manner such that the imaging material does not directly contact the biological substance; such imaging material will remain self-contained without causing significant tissue absorption, toxicity or undesired image distortion. The imaging material of choice is one which is capable of producing an emission or signal detectable external to the biological substance by suitable imaging instrumentation.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: September 30, 2003
    Assignee: The Regents of the University of Michigan
    Inventors: Cherry T. Thomas, Richard L. Wahl, Susan J. Fisher
  • Patent number: 6565827
    Abstract: Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: May 20, 2003
    Assignees: Coulter Pharmaceutical, Inc., The Regents of the University of Michigan
    Inventors: Mark S. Kaminski, Gregory M. Butchko, Stephan D. Glenn, Richard L. Wahl
  • Patent number: 6456869
    Abstract: An intraoperative probe system for preferentially detecting beta radiation over gamma radiation emitted from a radiopharmaceutical is described. In one embodiment, the probe system of the present invention is a probe having an ion-implanted silicon charged-particle detector for generating an electrical signal in response to received beta particles. In such an embodiment, a preamplifier may be located in close proximity to the detector filters and amplifies the electrical signal. Furthermore, a wire may be used to couple the probe to a processing unit for amplifying and filtering the electrical signal, and a counter may be utilized to analyze the resulting electrical signal to determine the number of beta particles being received by the detector. Alternatively, the wire can be replaced with an infrared or radio transmitter and receiver for wireless operation of the probe.
    Type: Grant
    Filed: March 6, 2000
    Date of Patent: September 24, 2002
    Assignee: The Regents of the University of Michigan
    Inventors: Raymond R. Raylman, Richard L. Wahl
  • Patent number: 6295680
    Abstract: A method and apparatus for detecting and optionally treating metabolically unstable or active atherosclerotic plaque is provided. The patient is given an I.V. solution containing a radioactive tracer which specifically accumulates in these plaques. A miniaturized radiation detector for local radioactivity imaging and detection is applied directly within the arterial lumen. The radiation detector identifies and differentiates the active, unstable plaque from the inactive, stable plaque. Treatment may optionally be provided through any of three forms, including opening the vessel by mechanical expansion, removing the plaque by mechanical ablation, or delivering a metabolism-altering agent to the affected site.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: October 2, 2001
    Assignee: The Regents of the University of Michigan
    Inventors: Richard L. Wahl, Robert J. Lederman
  • Patent number: 6287537
    Abstract: Methods for the treatment of lymphoma by adminstration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: September 11, 2001
    Assignees: The Regents of the University of Michigan, Coulter Pharmaceutical, Inc.
    Inventors: Mark S. Kaminski, Gregory M. Butchko, Stephan D. Glenn, Richard L. Wahl
  • Patent number: 6251362
    Abstract: A method for determining the number of millicuries to be administered to a patient so as to deliver a given centigray (cGy) dose to either the patient's lean body or the patient's total body. The method includes the steps of injecting a radioactive tracer into a patient, determining radiation levels in the whole body, calculating a geometric mean based on the radiation levels, determining the percent-injected activity remaining in the body at each time point, plotting the percent-injected activity versus calculated time from infusion on a log-linear graph, determining the effective half live and the rate of clearance from the log-linear graph, cross-indexing the effective half-life value with the patient's body weight, and multiplying the determined amount of therapeutic millicuries per centigray by the amount of desired centigray to be administered.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: June 26, 2001
    Assignee: The Regents of the University of Michigan
    Inventors: Richard L. Wahl, Kenneth R. Zasadny
  • Patent number: 6236880
    Abstract: A modular radiation detecting probe system includes a probe body having a handle portion and a distal portion to which an extension member is attached. The free end of the extension member is adapted to matingly attach and detach, one at a time, with various probe tips. An electronic signal acquisition system is disposed within the probe body and is coupled to receive a signal output from an attached probe tip. The acquisition system signal process the signal to discriminate between noise and a radiation signal detected by the probe tip. The probe body may include visual and/or audible devices to signal when the probe tip is adjacent a radiated area. The probe body may include a transmitted to transmit acquired signal data to an external signal processing unit, which may be a computer.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: May 22, 2001
    Inventors: Raymond R. Raylman, Richard L. Wahl
  • Patent number: 6090365
    Abstract: Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
    Type: Grant
    Filed: November 18, 1997
    Date of Patent: July 18, 2000
    Assignees: Coulter Pharmaceutical, Inc., Regents of the University of Michigan
    Inventors: Mark S. Kaminski, Gregory M. Butchko, Stephan D. Glenn, Richard L. Wahl
  • Patent number: 6076009
    Abstract: An intraoperative probe system for preferentially detecting beta radiation over gamma radiation emitted from a radiopharmaceutical is described. In one embodiment, the probe system of the present invention is a probe having an ion-implanted silicon charged-particle detector for generating an electrical signal in response to received beta particles. In such an embodiment, a preamplifier may be located in close proximity to the detector filters and amplifies the electrical signal. Furthermore, a wire may be used to couple the probe to a processing unit for amplifying and filtering the electrical signal, and a counter may be utilized to analyze the resulting electrical signal to determine the number of beta particles being received by the detector. Alternatively, the wire can be replaced with an infrared or radio transmitter and receiver for wireless operation of the probe.
    Type: Grant
    Filed: May 5, 1997
    Date of Patent: June 13, 2000
    Assignee: The University of Michigan
    Inventors: Raymond R. Raylman, Richard L. Wahl
  • Patent number: 6022521
    Abstract: A method for determining the number of millicuries to be administered to a patient as a dose so as to establish a given centigray (cGy) dose to either the patient's lean body or the patient's total body. The method includes the steps of injecting a radioactive tracer into a patient, determining radiation levels in the whole body, calculating a geometric mean based on the radiation levels, determining the percent-injected activity remaining in the body at each time point, plotting the percent-injected activity versus calculated time from infusion on a log-linear graph, determining the effective half live and the rate of clearance from the log-linear graph, cross-indexing the effective half-life value with the patient's body weight, and multiplying the determined amount of therapeutic millicuries per centigray by the amount of desired centigray to be administered.
    Type: Grant
    Filed: October 2, 1995
    Date of Patent: February 8, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: Richard L. Wahl, Kenneth R. Zasadny
  • Patent number: 6015542
    Abstract: Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy also described is a composition useful in the treatment of lymphoma.
    Type: Grant
    Filed: September 10, 1996
    Date of Patent: January 18, 2000
    Assignees: Coulter Pharmaceutical, Inc., The Regents of the University of Michigan
    Inventors: Mark S. Kaminski, Gregory M. Butchko, Stephan D. Glenn, Richard L. Wahl
  • Patent number: 5961457
    Abstract: A medical method and apparatus for the localization and biospy of lesions in a patient body part. A radiopharmaceutical is administered to the patient followed by placement of the body part within a scanner for obtaining emission data. The emission data is converted into Cartesian coordinates which are used to guide a sampling instrument for the biopsy of said lesion.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: October 5, 1999
    Assignee: The Regents of the University of Michigan
    Inventors: Raymond R. Raylman, Richard L. Wahl
  • Patent number: 5932879
    Abstract: An intraoperative system made be used for preferentially detecting beta radiation over gamma radiation emitted from a radiopharmaceutical. The system has ion-implanted silicon charged-particle detectors for generating signals in response to received beta particles. A preamplifier may be located in proximity to the detector filters and amplifies the signal. Also, a wire may be used to couple the probe to a processing unit for amplifying and filtering the signal.
    Type: Grant
    Filed: May 5, 1997
    Date of Patent: August 3, 1999
    Assignee: Regents of the University of Michigan
    Inventors: Raymond R. Raylman, Richard L. Wahl
  • Patent number: 5843398
    Abstract: Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
    Type: Grant
    Filed: April 26, 1996
    Date of Patent: December 1, 1998
    Assignees: Coulter Pharmaceutical, Inc., Regents of the University of Michigan
    Inventors: Mark S. Kaminski, Gregory M. Butchko, Stephan D. Glenn, Richard L. Wahl