Abstract: Advanced lithography techniques including sub-10 nm pitch patterning and structures resulting therefrom are described. Self-assembled devices and their methods of fabrication are described.

Abstract: The present invention is directed to the generation and use of recombinant rotavirus fusion proteins as immunogens to produce a protective immune response from immunized individuals. In one embodiment, the present invention contemplates a recombinant rotavirus fusion protein vaccine composition comprising a rotavirus subunit protein or immunogenic fragment thereof, and an adjuvant in combination with the recombinant rotavirus subunit fusion protein. In one aspect of this embodiment, the recombinant rotavirus fusion protein comprises a rotavirus subunit protein and a fusion partner protein in genetic association with the rotavirus subunit protein, wherein the fusion partner protein does not interfere with expression and immunogenicity of the rotavirus subunit protein, the fusion partner protein prevents complex formation by the rotavirus subunit protein, and the fusion partner protein facilitates purification of the recombinant rotavirus fusion protein.

Abstract: The present invention is directed to the generation and use of recombinant rotavirus fusion proteins as immunogens to produce a protective immune response from immunized individuals. In one embodiment, the present invention contemplates a recombinant rotavirus fusion protein vaccine composition comprising a rotavirus subunit protein or immunogenic fragment thereof, and an adjuvant in combination with the recombinant rotavirus subunit fusion protein. In one aspect of this embodiment, the recombinant rotavirus fusion protein comprises a rotavirus subunit protein and a fusion partner protein in genetic association with the rotavirus subunit protein, wherein the fusion partner protein does not interfere with expression and immunogenicity of the rotavirus subunit protein, the fusion partner protein prevents complex formation by the rotavirus subunit protein, and the fusion partner protein facilitates purification of the recombinant rotavirus fusion protein.

Abstract: The present invention relates to vaccine compositions comprising the VP6 protein from mouse (EDIM) and human (CJN) rotavirus strains. Methods of making the described immunogenic VP6 proteins and methods of using the described compositions are also disclosed.

Abstract: The present invention is directed to the generation and use of recombinant rotavirus fusion proteins as immunogens to produce a protective immune response from immunized individuals. In one embodiment, the present invention contemplates a recombinant rotavirus fusion protein vaccine composition comprising a rotavirus subunit protein or immunogenic fragment thereof, and an adjuvant in combination with the recombinant rotavirus subunit fusion protein. In one aspect of this embodiment, the recombinant rotavirus fusion protein comprises a rotavirus subunit protein and a fusion partner protein in genetic association with the rotavirus subunit protein, wherein the fusion partner protein does not interfere with expression and immunogenicity of the rotavirus subunit protein, the fusion partner protein prevents complex formation by the rotavirus subunit protein, and the fusion partner protein facilitates purification of the recombinant rotavirus fusion protein.

Abstract: A Novel isolated human rotavirus is disclosed. The novel human rotavirus of the present invention has derived its genomic segments from parental strains of different genogroups and/or serotypes, and is designated as HRV 248. It has been deposited with the American Type Culture Collection (ATCC), 12301 Parklawn Drive, Rockville, Md. 20852, and has been assigned the ATCC accession no. VR 2274. Also disclosed are novel vaccines formulated with the human rotaviruses of the present invention, and methods of vaccinating humans against human rotaviruses of multiple serotypes with such vaccines.

Abstract: Novel isolated human rotaviruses are disclosed. The novel human rotaviruses in accordance with the instant invention have derived their genomic segments from parental strains of different genogroups and/or serotypes. The novel rotaviruses of the present invention are designated as HRV 248, HRV 456, HRV 89-12C2, HRV 408 and CJN. The human rotavirus designated as HRV 89-12C2, HRV 408, HRV 248 and CJN have been deposited with the American Type Culture Collection (ATCC), 12301 Parklawn Drive, Rockville, Md. 20852, and have been assigned the following ATCC accession nos. VR 2272, VR 2273, VR 2274 and VR 2275, respectively. Also disclosed are novel vaccines formulated with the human rotaviruses of the instant invention, and methods of vaccinating humans against human rotaviruses of multiple serotypes with such vaccines.

Abstract: A radar transceiver and communications transmitter mounted on a target for communicating video signals from the radar to a remote receiver which has associated therewith an FFT detector for detecting scoring encounters, and a computer or microprocessor which first analyzes the video signals to provide signals indicative of the Doppler frequency shift at a plurality of different times through the use of autoregressive spectral estimation and then computes a model projectile flight pattern, including miss distance and closing velocity, which flight pattern fits the computed Doppler frequency shifts at the plurality of different times.

Abstract: In a radar enhancing transponder, apparatus for determining the percent of modulation on a received signal and apparatus for determining the percent of modulation on a signal transmitted by the transponder, with means for comparing the percentages to develope an error signal which is used to control the modulation in the transponder so that the percent of modulation on the return signal remains the same as that on the received signal.

Abstract: Regenerated cellulose sponges of incresed absorbency and rate of absorption formed by impregnating the sponge material with a solution or dispersion containing from 0.005 to 0.25% of a water-soluble or water-dispersible, high molecular weight, hydrophylic, film-forming polymer, drying the impregnated sponge and compressing it. The presence of the film-forming polymer allows the cutting of desired shaped individual sponges from the treated sponge material with a minimal formation of lint particles on the cut surfaces.

Abstract: Regenerated cellulose sponges of increased absorbency and rate of absorption formed by impregnating the sponge material with a solution or dispersion containing from 0.005% to 0.25% of a water-soluble or water-dispersible, high molecular weight, hydrophylic, film-forming polymer, drying the impregnated sponge and compressing it. The presence of the film-forming polymer allows the cutting of desired shaped individual sponges from the treated sponge material with a minimal formation of lint particles on the cut surfaces.