Abstract: Provided is a method for treating solid tumors, e.g. tumor invasiveness, and particularly inhibiting or controlling deregulated angiogenesis, using a sphingosine-1-phosphate receptor agonist, optionally in combination with a chemotherapeutic agent. The invention also comprises a combination of a sphingosine-1-phosphate receptor agonist with a chemotherapeutic agent.

Abstract: A denial-of-service network attack detection system is deployable in single-homed and multi-homed stub networks. The detection system maintains state information of flows entering and leaving the stub domain to determine if exiting traffic exceeds traffic entering the system. Monitors perform simple processing tasks on sampled packets at individual routers in the network at line speed and perform more intensive processing at the routers periodically. The monitors at the routers form an overlay network and communicate pertinent traffic state information between nodes. The state information is collected and analyzed to determine the presence of an attack.

Abstract: A mobile communication device comprising a rotary input device, wherein the rotary input device comprises an optical sensor configured to sense rotation of the rotary input device and a processor coupled to the rotary input device configured to process input from the rotary input device. The rotary input device can, in an embodiment provide rotation inputs and keypad inputs.

Abstract: Multiple paths in a communication network are provided between at least one source node and at least one destination node. The network arrangement may thus support either unicast transmission of data or multicast transmission. Measurements are made at nodes of the network to determine a partial network cost for data traversing the links in the multiple paths. An optimization procedure determines a distribution of the network traffic over the links between the at least one source node and the at least one destination node that incurs the minimum network cost.

Abstract: Apparatus for treating skin using abrasion lotion with particulate includes an appliance and an applicator. The appliance may include a motor for actuating the applicator, for example, by rotation or oscillation. The applicator may include an application surface for impressing and urging particulate upon skin when the surface is contacting skin and the motor is activated. The application surface may be made from a substantially unresilient material or a substantially inabsorbent material. To treat skin, abrasion lotion may be applied either on the surface of the applicator or directly on the skin. The surface may then be placed against skin, and the motor may be activated. When in motion, the application surface impresses particulate of the lotion upon the skin and urges the impressed particulate across the skin, thereby abrading and exfoliating the skin. The applicator may be moved over an area of the skin for complete treatment.

Abstract: A mobile telephone handset includes an elongated housing having a carabiner latch pivotally attached at a battery door on the rear side of the housing. The carabiner latch includes a hook portion having a spring-biased latch pivotally attached thereto for attaching the latch to a support element, such as a strap, loop or ring attached to a back-pack or other article of wearing apparel. The latch is stored within a door recess that receives the latch for storage purposes. The latch can be swung outwardly away from the housing to a variety of positions. A cylindrical projection is disposed within the door recess for frictionally receiving a central opening of the latch. A finger grip recess disposed within the door facilitates the grasping of the latch when it is disposed within the recess to facilitate swinging it away from the housing and out of the recess.

Abstract: Apparatus for skin treatment using abrasion lotion with particulate includes an appliance and an applicator. The appliance includes a motor for actuating the applicator by rotating or oscillating. The applicator includes a surface made from a substantially unresilient or inabsorbent material for impressing and urging the particulate upon the skin. In operation, the abrasion lotion is applied either on the surface of the applicator or directly to the skin, the surface placed against skin, and the motor activated. When in motion, the surface impresses particulate of the lotion upon the skin and urges the impressed particulate across the skin abrading and exfoliating it. The surface may include a field and a plurality of bosses disposed on it with channels between adjacent bosses, or a relief field. When the applicator is in motion, the bosses urge and push the abrasion lotion, and the relief field vectors particulate upon the skin.

Abstract: The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them.

Abstract: Apparatus for treating skin using abrasion lotion with particulate includes an appliance and an applicator. The appliance may include a motor for actuating the applicator, for example, by rotation or oscillation. The applicator may include an application surface for impressing and urging particulate upon skin when the surface is contacting skin and the motor is activated. The application surface may be made from a substantially unresilient material or a substantially inabsorbent material. To treat skin, abrasion lotion may be applied either on the surface of the applicator or directly on the skin. The surface may then be placed against skin, and the motor may be activated. When in motion, the application surface impresses particulate of the lotion upon the skin and urges the impressed particulate across the skin, thereby abrading and exfoliating the skin. The applicator may be moved over an area of the skin for complete treatment.

Abstract: A surface wave acoustic delay line is formed of a set of electrode assemblies disposed on the surface of a block of crystalline material propagative of a surface acoustic wave. In each of the assemblies, the electrodes are arranged in an interdigitated pattern. Reflected waves are cancelled by the construction of an additional electrode in each of an electrode assembly, the additional electrode extending only one-half the distance of the other electrodes and being spaced from an adjacent electrode by one-quarter wavelength. This introduces a 180.degree. phase shift between portions of relected waves which then cancel to remove the reflection. Also, in the case of closely spaced electrode assemblies, additional electrodes, equal in shape and size to the electrodes of the assemblies, are introduced between the assemblies in the form of a grid which propagates surface waves without reflection.

Abstract: Disclosed is a multiterminal acoustic surface wave transducer which has a unidirectional response characteristic over a selected operating frequency band and is capable of launching and receiving surface waves in a body of piezoelectric material. In a specific embodiment the transducer includes a plurality of sets of first, second and third parallel electrodes arranged in cascade on a surface of the piezoelectric material with a center-to-center electrode spacing equal to one-third wavelength of a selected frequency within the frequency band. Corresponding electrodes in each set are interconnected, with each group of interconnected electrodes forming a terminal of what is in this case a three terminal transducer. When a three phase electrical signal is supplied to the terminals of the transducer with a 120.degree. phase separation between terminals, the transducer will launch a corresponding surface wave in the piezoelectric material in the direction of phase progression among the electrodes.

Abstract: Apparatus under microprocessor control for use in communicating over a serial communication loop with a remote attached control unit. It is capable of establishing frame synchronization, interpreting commands, assembling data and transmitting bits on the loop. The apparatus also communicates with I/O devices over a demand/response interface.A microprocessor interface with the loop includes loop sync control which establishes bit synchronization and generates a restart pulse at bit receive time and bit send time. The execution of instructions by the microprocessor is stopped and the microprocessor enters a wait state when it has finished all previous work and is ready to receive a loop bit. When it is time to receive the loop bit the microprocessor is restarted in response to the restart pulse from the loop synchronization control.For output operations to a device, the microprocessor loads the device address and a device command or data into shift registers and initiates the transfer by setting a latch.