Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Abstract: The present invention provides a colored reinforced article of manufacture having a substantially uniform distribution of color. The colored reinforced article of manufacture comprises a fiber-reinforced thermosetting resin matrix and a non-appertured colored veil in the thermosetting resin matrix.

Abstract: An improved electrical panel design provides a modular, power-reliable, buss-lockout and true emergency-stop capabilities. Through the use of an interface, the approach eliminates numerous outdated, if not antiquated, parts, including safety locks, mechanical disconnect switches, E-stop safety relays, and safety Programmable controllers. The modular panel design saves interior panel space, permitting the use of single-door access, in some cases. Panel doors cannot be opened with live electricity without some form of electronic authorization, and a record of access is stored for future reference. Power may not then be reactivated with the doors opened, thereby virtually eliminating disconnect related accidents. Automatic shut down further occurs with a plant network emergency, ground-fault interruption, or panel door violation.

Abstract: The present invention provides a colored reinforced article of manufacture having a substantially uniform distribution of color. The colored reinforced article of manufacture comprises a fiber-reinforced thermosetting resin matrix and a non-appertured colored veil in the thermosetting resin matrix.

Abstract: The present invention provides a colored reinforced article of manufacture having a substantially uniform distribution of color. The colored reinforced article of manufacture comprises a fiber-reinforced thermosetting resin matrix and a non-appertured colored veil in the thermosetting resin matrix.

Abstract: An improved electrical panel design provides a modular, power-reliable, buss-lockout and true emergency-stop capabilities. Through the use of an interface, the approach eliminates numerous outdated, if not antiquated, parts, including safety locks, mechanical disconnect switches, E-stop safety relays, and safety Programmable controllers. The modular panel design saves interior panel space, permitting the use of single-door access, in some cases. Panel doors cannot be opened with live electricity without some form of electronic authorization, and a record of access is stored for future reference. Power may not then be reactivated with the doors opened, thereby virtually eliminating disconnect related accidents. Automatic shut down further occurs with a plant network emergency, ground-fault interruption, or panel door violation.

Abstract: An injection molded closure and a container has a closure with external ribs for preventing jamming together of adjacent closures in stacked relation, and facilitating self-alignment of stacked closures. The closure has a central circular panel and a sidewall extending generally upwardly therefrom. The sidewall has upper and lower vertical portions with a lateral offset portion extending therebetween, which define a plug-like portion of the closure. Upon engagement of the closure with a container, the plug-like section is inserted into the container opening. The ribs are spaced peripherally about the outside of the closure and include an upper closure-engaging surface for contact with the rim of another closure stacked therebelow, and a lower closure-engaging surface for contact with the lateral offset portion of the other closure stacked therebelow.

Abstract: A large easy opening plastic lid, such as for a five gallon paint can, having a peripheral flange with an annular locking ring that engages an annular bead on a container sidewall to retain the lid in sealed engagement with the container. The flange is formed with a plurality of peripherally spaced frangible lines of weakness, which, when broken, segment the peripheral flange into separate flange segments, each having a segment of the locking ring. Following rupture of the flange along the frangible lines of weakness, each of the flange segments is independently pivotable between two positions, a first lowered position in which the respective segments of the locking ring engage with the container bead to securely retain the lid on the container, and a second raised or winged position in which all of the respective segments of the locking ring are disengaged from the container bead to facilitate easy removal and replacement of the lid.

Abstract: A reclosable plastic lid having a peripheral flange with a substantially annular projection that engages an annular shoulder on a container sidewall to retain the lid initially on the container full of contents. The flange is formed with a weakened portion defining a tear strip which removes to detach spaced portions of the flange along with portions of the annular projections leaving flange portions which are folded upwardly about hinge lines to retracted positions out of locking engagement with said annular shoulder. With the tear strip removed and the remaining flange portions pivoted outwardly toward horizontal positions, it is much easier to remove the lid from the container. When the lid is re-applied to reclose the container, the remaining attached, flange portions are pivoted down into engagement with container shoulder to retain the lid on the container and thereby, prevent spillage of the container's contents.

Abstract: Disclosed is a plastic injection molded container and closure assembly wherein the closure has a plug-like section and an outer skirt. The plug-like section includes a vertical cylindrical wall having upper and lower annular nesting surfaces for nesting closures in a stack. An annular top wall outwardly extends from the vertical cylindrical wall upper end and a skirt depends downwardly from the outer periphery of the outer top wall. The lower free end of the skirt includes a bead defining a thick cross-sectional area on the skirt for engaging the upper flange of a container when mated therewith. The container upper flange extends outwardly and downwardly from the open end of the container and has a free end engaging the bead on the closure skirt. The container has a sealing lip of increased cross-sectional thickness at the container rim projecting radially inwardly into sealing engagement with the vertical cylindrical wall on the plug-like section.

Abstract: Disclosed is a closure and container assembly for a large-volume container, having an upper rim portion encircled by upper and lower spaced-apart outwardly-extending flanges. The closure includes a one-piece plastic body having a top panel and an encircling skirt downwardly depending from the top panel and integrally attached thereto. A removable tear strip is formed on the lower portion of the skirt and when the closure is fully installed, has a lower free end adjacent the lower flange of the container. A locking bead extends radially inwardly from the tear strip so as to engage an upper flange of the container, retaining the closure thereto. The tear strip includes a first pull tab and a line of weakness to provide a breakable connection between the lower tear strip and the upper portion of the skirt. A second pull tab is located between the first pull tab and the trailing end of the tear strip and remains attached to the closure after removal of the tear strip.

Abstract: Disclosed is a plastic injection molded closure having a plug-like section and an outer skirt. The plug-like section includes a vertical cylindrical wall having upper and lower annular nesting surfaces for nesting containers in a stack. An annular top wall outwardly extends from the vertical cylindrical wall upper end and a skirt depends downwardly from the outer periphery of the outer top wall. The lower free end of the skirt includes a bead defining a thick cross-sectional area on the skirt for engaging the upper flange of a container when mated therewith. The container upper flange extends outwardly and downwardly from the open end of the container and has a free end engaging the bead on the closure skirt. A plurality of radially inwardly directed ribs extend from the cylindrical wall and present upper surfaces to a superimposed closure that may be stacked therewith.

Abstract: Disclosed is a container and closure assembly including a container having a substantially circular opening and an outer wall containing an upper retention bead and a lower, regularly-outwardly extending security ring. The closure includes a one-piece plastic body having a top panel and an encircling skirt depending from the top panel so as to be integrally attached thereto. The skirt includes a groove for locking engagement with the retention bead to retain the closure on the container. A circumferential line of weakness in the skirt wall defines a removable tear strip having a movable free edge and which is removable from an upper portion of the skirt wall by fracturing the skirt wall along the upper line of weakness. A tear strip is weakened so as to form a plurality of circumferentially-spaced segments throughout the substantial entirety of its periphery. The segments are separable one from another in response to a prying or wedging force applied to the tear strip at the free edge thereof.

Abstract: A one piece plastic closure is provided for a container having a retention bead. The enclosure includes a top panel with a skirt interlocked with the retention bead. A removable tear strip on the skirt includes a pull tab to facilitate the grasping thereof. A lift tab, connected to the upper portion of the skirt, facilitates removal of the closure after the tear strip has been torn away from the enclosure to remove its interlocking with the retention bead. A frangible bridge interconnects the pull tab and the lift tab and pulls the lift tab into a more accessible position as the tear strip is removed.

Abstract: An inexpensive, one-piece closure has a press-fit sealed engagement with a container which has a closure retention bead adjacent the open mouth of the container. A tear-off strip provides a tamper-evident feature and includes a pull tab for tearing off the strip thereby exposing a lift tab by which the closure may be lifted from the container. The lift tab is useful where the container has a security or saturn ring on the its sidewall projecting outwardly immediately below the skirt of the closure to limit access to the lower edge of the tear strip. Preferably, the lift-off tab is initially partially hidden behind the pull tab and is connected thereto, and the lift-off tab is exposed and pulled to a position to be accessible after the pull tab is grasped and pulled by the user to remove the tear off strip.

Abstract: Apparatus for forming objects from molten material includes a mold frame and a movable mold side having complementary faces that define molding cavities. The mold frame includes a mold housing having an internally heated manifold which has a molten plastic distribution channel system for conducting molten plastic to injection nozzle passageways, each having a restricted discharge nozzle that discharges the plastic into a molding cavity. Within each injection nozzle passageway is a heater probe which has an internal heater, preferably an electrical cartridge heater. The probe is secured by an integral seating flange to the mold housing to hold the probe coaxially aligned in the injection nozzle passageway and to hold the probe against shifting with thermal expansion and contraction of the manifold. The integral rear flange is positioned in front of manifold block and has a connecting passageway that communicates the manifold distribution channel with the injection nozzle passageway.

Abstract: Apparatus for forming objects from molten material includes a mold frame and a movable mold side having complementary faces that define molding cavities. The mold frame includes a mold housing having an internally heated manifold which has a plastic distribution channel for feeding plastic to an injection nozzle passageway having a restricted discharge nozzle that discharges the plastic into a molding cavity. Within the injection nozzle passageway is a heater probe which has an internal heater, preferably an electrical cartridge heater. The probe is secured by an integral seating flange to the mold housing to hold the probe coaxially aligned in the injection nozzle passageway and to hold the probe against shifting with thermal expansion and contraction of the manifold.