Patents by Inventor Richard LeCoultre

Richard LeCoultre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD AND SYSTEM EMPLOYING DISTINGUISHABLE POLYMERASES FOR DETECTING TERNARY COMPLEXES AND IDENTIFYING COGNATE NUCLEOTIDES
    Publication number: 20220298553
    Abstract: Method of identifying a cognate nucleotide (i.e., the “next correct nucleotide”) for a primed template nucleic acid molecule. In some embodiments, an ordered or random array of primed target nucleic acids characterized by different cognate nucleotides can be evaluated using a single imaging step to identify different cognate nucleotides for a collection of different primed template nucleic acid molecules. An optional incorporation step can follow the identifying step. A polymerase different from the ones used in the binding and examination steps can be used to incorporate a nucleotide, such as a reversible terminator nucleotide, preliminary to identification of the next cognate nucleotide.
    Type: Application
    Filed: December 29, 2021
    Publication date: September 22, 2022
    Applicant: Omniome, Inc.
    Inventors: Corey M. DAMBACHER, Devon CAYER, Richard LECOULTRE, Joseph ROKICKI, Kerry WILSON, Eugene TU, Kandaswamy VIJAYAN
  • Method and system employing distinguishable polymerases for detecting ternary complexes and identifying cognate nucleotides
    Patent number: 11248254
    Abstract: Method of identifying a cognate nucleotide (i.e., the “next correct nucleotide”) for a primed template nucleic acid molecule. In some embodiments, an ordered or random array of primed target nucleic acids characterized by different cognate nucleotides can be evaluated using a single imaging step to identify different cognate nucleotides for a collection of different primed template nucleic acid molecules. An optional incorporation step can follow the identifying step. A polymerase different from the ones used in the binding and examination steps can be used to incorporate a nucleotide, such as a reversible terminator nucleotide, preliminary to identification of the next cognate nucleotide.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: February 15, 2022
    Assignee: OMNIOME, INC.
    Inventors: Corey M. Dambacher, Devon Cayer, Richard LeCoultre, Joseph Rokicki, Kerry Wilson, Eugene Tu, Kandaswamy Vijayan
  • METHOD AND SYSTEM EMPLOYING DISTINGUISHABLE POLYMERASES FOR DETECTING TERNARY COMPLEXES AND IDENTIFYING COGNATE NUCLEOTIDES
    Publication number: 20180187245
    Abstract: Method of identifying a cognate nucleotide (i.e., the “next correct nucleotide”) for a primed template nucleic acid molecule. In some embodiments, an ordered or random array of primed target nucleic acids characterized by different cognate nucleotides can be evaluated using a single imaging step to identify different cognate nucleotides for a collection of different primed template nucleic acid molecules. An optional incorporation step can follow the identifying step. A polymerase different from the ones used in the binding and examination steps can be used to incorporate a nucleotide, such as a reversible terminator nucleotide, preliminary to identification of the next cognate nucleotide.
    Type: Application
    Filed: December 21, 2017
    Publication date: July 5, 2018
    Applicant: Omniome, Inc.
    Inventors: Corey M. Dambacher, Devon Cayer, Richard LeCoultre, Joseph Rokicki, Kerry Wilson, Eugene Tu, Kandaswamy Vijayan