Patents by Inventor Richard Lee Damren
Richard Lee Damren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11969701Abstract: The system and method of the invention pertains to an axial flux stator is implemented to replace the drive-end magnets and the drive motor. The axial flux stator comprises a control circuit to control the voltage and current provided to the stator, to measure the torque and speed of rotation, and to measure the magnetic flux and magnetic flux density produced by the axial flux stator and impeller magnets, individually or in combination. The axial flux stator comprises a plurality of current carrying elements to produce magnetic flux in an axial direction and drive the impeller.Type: GrantFiled: November 28, 2020Date of Patent: April 30, 2024Assignee: Global Life Sciences Solutions USA LLCInventors: James Pellegrino Alexander, Klaus Gebauer, David Allan Torrey, Ashraf Said Atalla, Sima Didari, Richard Lee Damren
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Publication number: 20230313100Abstract: A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.Type: ApplicationFiled: March 28, 2023Publication date: October 5, 2023Applicant: CYTIVA SWEDEN ABInventors: KLAUS GEBAUER, NAGARAJ RAGHAVENDRA RAO, ANINDYA KANTI DE, ANINDYA SENGUPTA, MATS OLSSON, COLIN R. TUOHEY, JONATHAN A. KENNEY, RICHARD LEE DAMREN, RALPH STANKOWSKI, NIRMAL KUMAR THANIKACHALAM
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Patent number: 11643627Abstract: A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.Type: GrantFiled: December 27, 2017Date of Patent: May 9, 2023Assignee: CYTIVA SWEDEN ABInventors: Klaus Gebauer, Nagaraj Raghavendra Rao, Anindya Kanti De, Anindya Sengupta, Mats Olsson, Colin R. Tuohey, Jonathan A. Kenney, Richard Lee Damren, Ralph Stankowski, Nirmal Kumar Thanikachalam
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Patent number: 11274274Abstract: The invention discloses a bioreactor apparatus (1;101;201;301) for cultivation of cells comprising: a) a disposable bioreactor vessel (2) with one or more walls (3,4,5) defining an inner volume (6), at least one port (10) in a wall, wherein the disposable bioreactor vessel is positioned in a rigid support structure (8;108); and b) a heater (9;109;209;309), capable of heating an amount of culture medium to a target temperature in the range of 55-95° C., while the amount of culture medium is being confined in or conveyed to the inner volume.Type: GrantFiled: April 12, 2016Date of Patent: March 15, 2022Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Colin R. Tuohey, Richard Lee Damren, Thomas John Erdenberger, Parish M. Galliher, Patrick M. Guertin
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Patent number: 11130073Abstract: Disclosed herein is a system and method for condensing moisture in a gas stream entering or leaving a bioreactor, the system comprising: a contact condenser container fluidically coupled to the bioreactor through an exhaust line; a condensate accumulator fluidically coupled to the contact condenser container through at least a first condensate line and a second condensate line; the condensate accumulator further fluidically coupled to the bioreactor through a condensate overflow line; a first condensate control device disposed on the first condensate line and configured to control a flow of condensate leaving the contact condenser container and entering the condensate accumulator; and a second condensate control device disposed on the second condensate line and configured to control a flow of condensate leaving the condensate accumulator to be mixed with the gas stream.Type: GrantFiled: January 27, 2020Date of Patent: September 28, 2021Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Richard Lee Damren, Colin Tuohey, Patrick Guertin, Parrish Galliher
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Patent number: 11097236Abstract: The system and method of the invention pertains to an axial flux stator is implemented to replace the drive-end magnets and the drive motor. The axial flux stator comprises a control circuit to control the voltage and current provided to the stator, to measure the torque and speed of rotation, and to measure the magnetic flux and magnetic flux density produced by the axial flux stator and impeller magnets, individually or in combination. The axial flux stator comprises a plurality of current carrying elements to produce magnetic flux in an axial direction and drive the impeller.Type: GrantFiled: March 8, 2017Date of Patent: August 24, 2021Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: James Pellegrino Alexander, Klaus Gebauer, David Allan Torrey, Ashraf Said Atalla, Sima Didari, Richard Lee Damren
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Publication number: 20210077961Abstract: The system and method of the invention pertains to an axial flux stator is implemented to replace the drive-end magnets and the drive motor. The axial flux stator comprises a control circuit to control the voltage and current provided to the stator, to measure the torque and speed of rotation, and to measure the magnetic flux and magnetic flux density produced by the axial flux stator and impeller magnets, individually or in combination. The axial flux stator comprises a plurality of current carrying elements to produce magnetic flux in an axial direction and drive the impeller.Type: ApplicationFiled: November 28, 2020Publication date: March 18, 2021Inventors: JAMES PELLEGRINO ALEXANDER, KLAUS GEBAUER, DAVID ALLAN TORREY, ASHRAF SAID ATALLA, SIMA DIDARI, RICHARD LEE DAMREN
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Patent number: 10934515Abstract: The aspects of the disclosed embodiments generally relate to an apparatus which allows for the controlled addition of antifoam to the foam present in the headspace of a disposable single-use bioreactor in a reliable manner. The aspects of the disclosed embodiments also generally relate to a method of using such apparatus which allows for the controlled addition of antifoam to the foam present in the headspace of a disposable single-use bioreactor in a reliable manner. The aspects of the disclosed embodiments generally relate to antifoam systems, methods and apparatus, and more particularly, to an antifoam device operably connected to a single use biobag.Type: GrantFiled: August 15, 2016Date of Patent: March 2, 2021Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventor: Richard Lee Damren
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Patent number: 10857510Abstract: A bioprocess mixer (1), which comprises: —a support vessel (2) with at least one side wall (3, 4, 5, 6) and a bottom wall (7), where the walls define a support vessel inner volume (8), and at least a first (9) and a second (10) magnetic impeller drive unit; and —a flexible bag (11, 111) adapted to fit inside the support vessel inner volume, where the bag has at least one bag side wall (12, 112, 13, 113, 14, 15), a bag bottom wall (16, 116) and a bag top wall (17, 117) defining a bag inner volume (18), and at least a first (19) and a second (20) magnetic impeller rotatably attached to a bag wall in the bag inner volume.Type: GrantFiled: April 11, 2016Date of Patent: December 8, 2020Assignee: Global Life Sciences Solutions USA LLCInventors: Patrik Berndt Akerstrom, Richard Lee Damren, Colin R. Tuohey, Thomas Erdenberger, Jonathan Kenney, David Lawrence Brazell, Wei Jin, Roberto Miguel Cabral, Sampath Telikcherla Kandala
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Publication number: 20200155962Abstract: Disclosed herein is a system and method for condensing moisture in a gas stream entering or leaving a bioreactor, the system comprising: a contact condenser container fluidically coupled to the bioreactor through an exhaust line; a condensate accumulator fluidically coupled to the contact condenser container through at least a first condensate line and a second condensate line; the condensate accumulator further fluidically coupled to the bioreactor through a condensate overflow line; a first condensate control device disposed on the first condensate line and configured to control a flow of condensate leaving the contact condenser container and entering the condensate accumulator; and a second condensate control device disposed on the second condensate line and configured to control a flow of condensate leaving the condensate accumulator to be mixed with the gas stream.Type: ApplicationFiled: January 27, 2020Publication date: May 21, 2020Applicant: General Electric CompanyInventors: Richard Lee Damren, Colin Tuohey, Patrick Guertin, Parrish Galliher
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Patent number: 10576393Abstract: Disclosed herein is a system and method for condensing moisture in a gas stream entering or leaving a bioreactor, the system comprising: a contact condenser container fluidically coupled to the bioreactor through an exhaust line; a condensate accumulator fluidically coupled to the contact condenser container through at least a first condensate line and a second condensate line; the condensate accumulator further fluidically coupled to the bioreactor through a condensate overflow line; a first condensate control device disposed on the first condensate line and configured to control a flow of condensate leaving the contact condenser container and entering the condensate accumulator; and a second condensate control device disposed on the second condensate line and configured to control a flow of condensate leaving the condensate accumulator to be mixed with the gas stream.Type: GrantFiled: December 18, 2015Date of Patent: March 3, 2020Assignee: GENERAL ELECTRIC COMPANYInventors: Richard Lee Damren, Colin Tuohey, Patrick Guertin, Parrish Galliher
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Patent number: 10519409Abstract: A fluid transfer assembly for single use bioreactors includes a fluid transfer housing that can be mounted to the impeller shaft using a bearing that places the fluid transfer assembly directly below the lowest impeller but allows the impeller shaft to spin inside independently of the fluid transfer assembly. A fluid conduit connects the fluid transfer housing to a port in the single use bag wall which allows fluids to be introduced into the sparger and which also helps prevent the fluid transfer assembly from rotating with the impeller shaft.Type: GrantFiled: December 22, 2015Date of Patent: December 31, 2019Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Richard Lee Damren, Colin R. Tuohey
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Publication number: 20190322970Abstract: A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.Type: ApplicationFiled: December 27, 2017Publication date: October 24, 2019Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: KLAUS GEBAUER, NAGARAJ RAGHAVENDRA RAO, ANINDYA KANTI DE, ANINDYA SENGUPTA, MATS OLSSON, COLIN R. TUOHEY, JONATHAN A. KENNEY, RICHARD LEE DAMREN, RALPH STANKOWSKI, NIRMAL KUMAR THANIKACHALAM
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Publication number: 20190282980Abstract: The system and method of the invention pertains to an axial flux stator is implemented to replace the drive-end magnets and the drive motor. The axial flux stator comprises a control circuit to control the voltage and current provided to the stator, to measure the torque and speed of rotation, and to measure the magnetic flux and magnetic flux density produced by the axial flux stator and impeller magnets, individually or in combination. The axial flux stator comprises a plurality of current carrying elements to produce magnetic flux in an axial direction and drive the impeller.Type: ApplicationFiled: March 8, 2017Publication date: September 19, 2019Applicant: GENERAL ELECTRIC COMPANYInventors: JAMES PELLEGRINO ALEXANDER, KLAUS GEBAUER, DAVID ALLAN TORREY, ASHRAF SAID ATALLA, SIMA DIDARI, RICHARD LEE DAMREN
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Patent number: 10335750Abstract: The system and method of the invention pertains to use of a back iron on one or both ends of the impeller to increase the magnetic field density, and thus strengthen the magnetic coupling. In addition, pie-shaped (i.e. wedge) magnets, or variations thereof, increase the utilization volume and hence provide higher torque to allow the use of less expensive material (e.g. ferrites). In another embodiment, the rotor side is constructed with a Halbach array which increases the torque without the need to add a back iron piece. In another embodiment, an axial flux stator is implemented to replace the drive-end magnets and the drive motor.Type: GrantFiled: March 31, 2016Date of Patent: July 2, 2019Assignee: General Electric CompanyInventors: Ashraf Said Atalla, Klaus Gebauer, Richard Lee Damren, David Allan Torrey, Sima Didari
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Publication number: 20180223240Abstract: The aspects of the disclosed embodiments generally relate to an apparatus which allows for the controlled addition of antifoam to the foam present in the headspace of a disposable single-use bioreactor in a reliable manner. The aspects of the disclosed embodiments also generally relate to a method of using such apparatus which allows for the controlled addition of antifoam to the foam present in the headspace of a disposable single-use bioreactor in a reliable manner. The aspects of the disclosed embodiments generally relate to antifoam systems, methods and apparatus, and more particularly, to an antifoam device operably connected to a single use biobag.Type: ApplicationFiled: August 15, 2016Publication date: August 9, 2018Applicant: GE Healthcare Bio-Sciences Corp.Inventor: Richard Lee Damren
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Publication number: 20180126344Abstract: A bioprocess mixer (1), which comprises: —a support vessel (2) with at least one side wall (3, 4, 5, 6) and a bottom wall (7), where the walls define a support vessel inner volume (8), and at least a first (9) and a second (10) magnetic impeller drive unit; and —a flexible bag (11, 111) adapted to fit inside the support vessel inner volume, where the bag has at least one bag side wall (12, 112, 13, 113, 14, 15), a bag bottom wall (16, 116) and a bag top wall (17, 117) defining a bag inner volume (18), and at least a first (19) and a second (20) magnetic impeller rotatably attached to a bag wall in the bag inner volume.Type: ApplicationFiled: April 11, 2016Publication date: May 10, 2018Inventors: Patrik Berndt Akerstrom, Richard Lee Damren, Colin R. Tuohey, Thomas Erdenberger, Jonathan Kenney, David Lawrence Brazell, Wei Jin, Roberto Miguel Cabral, Sampath Telikcherla Kandala
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Publication number: 20180119084Abstract: The invention discloses a bioreactor apparatus (1;101;201;301) for cultivation of cells comprising: a) a disposable bioreactor vessel (2) with one or more walls (3,4,5) defining an inner volume (6), at least one port (10) in a wall, wherein the disposable bioreactor vessel is positioned in a rigid support structure (8;108); and b) a heater (9;109;209;309), capable of heating an amount of culture medium to a target temperature in the range of 55-95° C., while the amount of culture medium is being confined in or conveyed to the inner volume.Type: ApplicationFiled: April 12, 2016Publication date: May 3, 2018Inventors: Colin R. Tuohey, Richard Lee Damren, Thomas John Erdenberger, Parish M. Galliher, Patrick M. Guertin
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Publication number: 20170362555Abstract: A fluid transfer assembly for single use bioreactors includes a fluid transfer housing that can be mounted to the impeller shaft using a bearing that places the fluid transfer assembly directly below the lowest impeller but allows the impeller shaft to spin inside independently of the fluid transfer assembly. A fluid conduit connects the fluid transfer housing to a port in the single use bag wall which allows fluids to be introduced into the sparger and which also helps prevent the fluid transfer assembly from rotating with the impeller shaft.Type: ApplicationFiled: December 22, 2015Publication date: December 21, 2017Inventors: Richard Lee Damren, Colin R. Tuohey
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Patent number: RE49606Abstract: A bioprocess mixer (1), which comprises: —a support vessel (2) with at least one side wall (3, 4, 5, 6) and a bottom wall (7), where the walls define a support vessel inner volume (8), and at least a first (9) and a second (10) magnetic impeller drive unit; and —a flexible bag (11, 111) adapted to fit inside the support vessel inner volume, where the bag has at least one bag side wall (12, 112, 13, 113, 14, 15), a bag bottom wall (16, 116) and a bag top wall (17, 117) defining a bag inner volume (18), and at least a first (19) and a second (20) magnetic impeller rotatably attached to a bag wall in the bag inner volume.Type: GrantFiled: May 6, 2021Date of Patent: August 15, 2023Assignee: Global Life Sciences Solutions USA LLCInventors: Patrik Berndt Akerstrom, Richard Lee Damren, Colin R. Tuohey, Thomas Erdenberger, Jonathan Kenney, David Lawrence Brazell, Wei Jin, Roberto Miguel Cabral, Sampath Telikcherla Kandala