Abstract: The invention relates to an indane compound according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, n and p are as defined herein. The compounds are useful for treating antibacterial infection either as stand-alone antibiotics, or in combination with further antibiotics.

Abstract: The invention relates to an indane compound according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, n and p are as defined herein. The compounds are useful for treating antibacterial infection either as stand-alone antibiotics, or in combination with further antibiotics.

Abstract: The invention provides a combinations and pharmaceutical compositions comprising (i) a compound which is an indane according to Formula (I) or a pharmaceutically acceptable salt thereof; and (ii) one or more CFTR modulator; wherein R1, R2, R3, R4, n, Lk, (A), G and m are as defined herein. Also provided are therapeutic uses of such combinations and compositions in the treatment of conditions such as cystic fibrosis.

Abstract: The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, n and p are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics.

Abstract: The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, n and p are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics.

Abstract: The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p, q, L, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.

Abstract: In some cases, one or more tasks may be selected for inclusion within a content item or portions of a content item such as different story arcs. Each such task may be completed based, at least in part, on an associated set of one or more actions and an associated set of one or more parameters. Also, in some cases, one or more node layouts may be generated in association with a content item or portions of a content item. Each node within a node layout may, for example, have at least one associated task within a respective content item or content item portion.

Abstract: A media universe (MU) system may leverage network-based resources to store and maintain a database of content for a world encompassed by the media universe. One or more layers of content including a client layer may be overlaid on a base or canonical layer of content in the MU database to enable an immersive client experience within the media universe. Clients may participate within the media universe via the MU system, for example to create customized digital assets. Client-generated content or other content may be dynamically integrated into digital media based within the media universe, for example by leveraging the repository to store and access the client-generated content, and network-based computing resources to dynamically insert the content into digital media for streaming to the clients. Client-generated content may be promoted to intermediate layers and/or to canon within the MU database, for example by community voting, popularity, and so on.

Abstract: The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p, q, L, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.

Abstract: A media universe system may leverage network-based computation resources and services, for example a streaming service, and a digital asset repository or repository service to dynamically provide active content in digital media of the media universe streamed to the client. An asset repository may contain digital assets including 3D models of objects and characters used in the digital media. Client interactions with digital media via a client interface may be mapped to particular objects, characters, locations, etc. within the media universe according to the digital assets from the repository. Most or all content within a rendered scene streamed to a client device may be rendered as active content. Clients may interact with the active content to, for example, obtain contextual information about the corresponding objects, manipulate and explore objects, discover hidden content, reveal hidden storylines, order merchandise (e.g., via 3D printing) related to the content, etc.

Abstract: A media universe system may provide digital media content to clients via methods and apparatus that provide interactive and immersive viewing experiences to the clients. A repository service may store digital assets for the media universe and maintain an asset tracking database that may track how the digital assets of the media universe relate to one another over time within a world encompassed by the media universe. The repository service may also maintain mappings between the digital assets and other content of the media universe. The repository service may serve as a centralized continuity database for the world and the media universe. Providing an accessible, scalable, network-based location for the continuity database may enable developers to build interactive experiences for users to explore the world of the media universe, both spatially and temporally.

Abstract: Methods and apparatus for providing interactive and customized experiences to clients of a media universe (MU) system. The MU system may leverage network-based computation resources and services, for example a streaming service, and a digital asset repository or repository service to dynamically provide customized and customizable experiences to clients. Clients may create or modify digital assets (e.g., 3D models of characters, objects, etc.), which may be stored to the asset repository. The MU system may dynamically render digital media content of the media universe (e.g., movies, games, etc.) that includes the clients' custom digital assets (characters, objects, backgrounds, etc.) inserted into appropriate locations, and stream the dynamically customized content to respective client devices. Effectively, a client layer of content is overlaid on a base or canonical layer of content within digital media of the media universe.

Abstract: A square or rectangular hay baler (10) comprises a fore and aft hay bale forming zone, and a cut vegetation pick up and delivery arrangement for delivering cut vegetation to the hay bale forming zone. A compression plunger (19) of the hay baler (10) is movable in the fore and aft direction for compressing cut vegetation into a bale in the hay bale forming zone. A reservoir (23) retains a supply of non-toxic liquid surfactant or lubricant, and a pump (25) is provided for pumping the nontoxic liquid surfactant or lubricant from the reservoir (23) at a supply pressure to one or more discharge outlets (32) in the hay baler (10). Thereby, inwardly facing surfaces in the fore and aft hay bale forming zone are at least partially coated with the non-toxic liquid surfactant or lubricant.

Abstract: This invention relates to novel compounds which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of cancer.

Abstract: A hay baler (10) comprises a fore and aft hay bale forming zone, and a cut vegetation pick up and delivery arrangement for delivering cut vegetation to the hay bale forming zone. A compression plunger (19) of the hay baler (10) is movable in the fore and aft direction for compressing cut vegetation into a bale in the hay bale forming zone. A reservoir (23) retains a supply of non-toxic liquid surfactant or lubricant, and a pump means (25) is provided for pumping the non-toxic liquid surfactant or lubricant from the reservoir (23) at a supply pressure to one or more discharge outlets (32) in the hay baler (10). Thereby, inwardly facing surfaces in the fore and aft hay bale forming zone are at least partially coated with the non-toxic liquid surfactant or lubricant.

Abstract: In some cases, one or more tasks may be selected for inclusion within a content item or portions of a content item such as different story arcs. Each such task may be completed based, at least in part, on an associated set of one or more actions and an associated set of one or more parameters. Also, in some cases, one or more node layouts may be generated in association with a content item or portions of a content item. Each node within a node layout may, for example, have at least one associated task within a respective content item or content item portion.

Abstract: In some cases, one or more tasks may be selected for inclusion within a content item or portions of a content item such as different story arcs. Each such task may be completed based, at least in part, on an associated set of one or more actions and an associated set of one or more parameters. Also, in some cases, one or more node layouts may be generated in association with a content item or portions of a content item. Each node within a node layout may, for example, have at least one associated task within a respective content item or content item portion.

Abstract: The invention relates to an apparatus and a method for simultaneous multiple medicine administration. The apparatus according to the invention comprises a housing in which at least two entry chambers and a collecting point are formed, wherein each entry chamber communicates with the collecting point via a flow path respectively and wherein in each flow path at least one penetration member is arranged, which causes a decrease in pressure downstream to the penetration member with respect to the pressure upstream to the penetration member. According to the method of the invention the independency of flow rates is eliminated irrespective of the equipment that is used, wherein a fluid is fed to a collecting point via separate flow paths and at least one penetration member is arranged within each flow path causing a decrease in pressure downstream to the penetration member with respect to the pressure upstream to the penetration member.

Abstract: A roller assembly for applying force to the ground is disclosed. The assembly includes a body adapted to be mounted to a vehicle for moving the assembly, and supports including a first support member supporting a plurality of rollers for applying force to the ground, and a respective piston connected to each roller, the rollers connected via a respective pressure chamber to the corresponding first support member to resist movement of the pistons towards the first support member. The first support member pivotably connected to the body via a first axis such that pivoting movement of the first support member about the first axis as a result of a first torque about an axis has a component about an axis transverse to the direction of travel such that engagement of the rollers with the ground causes a second torque on the first support member opposing the first torque.