Abstract: A method of protecting animal tissue particularly skin, from damage caused by radiation exposure, by contacting the tissue with a ketone ester, a method of protecting skin, reducing the deterioration of skin or maintaining or improving the properties of skin by applying topically to the skin a ketone body comprising (R)-3-hydroxybutyrate moieties is disclosed. A ketone body comprising (R)-3-hydroxybutyrate moieties, especially enantiomerically enriched R-1,3-hydroxybutyl-(R)-3-hydroxybutyrate, for such uses is also provided.

Abstract: Expanded graphite and/or vermiculite are introduced into the friction lining mixture to eliminate or substantially reduce the amount of binder present therein. The friction lining at most contains from 2.5% by weight of binder. By omitting/reducing binder, the production is very stable and the friction linings can be easily reproduced. The process steps of hardening (including the hardening furnace) and scorching (including the necessary equipment) can be omitted when making such friction linings.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: The present invention is directed to a safety light, such as a barricade lamp. The safety light comprises a light member and a power source comprising a non-rechargeable battery source and a rechargeable battery source. A solar cell array is also included and is adapted to recharge the rechargeable battery source. A battery monitor and a power control processor are configured to control the supply of power to the light member by causing the rechargeable battery source to power the light member until the charge level of the rechargeable battery source falls below a certain level, at which time the power control processor causes power from the non-rechargeable battery source to power the light member.

Abstract: Described herein is the surprising discovery that ketone bodies protect cell and tissues from ionizing radiation. Based on this finding, methods of protecting animal tissue and cells from damage caused by radiation exposure are disclosed which include, contacting the tissue with a therapeutically effective amount of an agent including at least one ketone ester, thereby protecting the tissue from radiation damage. Ketone esters can be used to minimize, reduce and/or prevent tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage.

Abstract: This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides from the venom of the tarantula Pamphobeteus nigricolor and their use in methods of inhibiting Nav1.7 and for treating or preventing conditions associated with Nav1.7 activity such as neuropathic, inflammatory and nociceptive pain.

Abstract: This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides from the venom of the tarantula Pamphobeteus nigricolor and their use in methods of inhibiting Nav1.7 and for treating or preventing conditions associated with Nav1.7 activity such as neuropathic, inflammatory and nociceptive pain.

Abstract: Glaucoma can be treated by implanting an intraocular shunt in the eye. The implantation can be performed by first determining an entry area below a corneal limbus of an eye. Thereafter, the intraocular shunt can be inserted into eye tissue through the entry area such that an inflow end of the shunt is positioned in the anterior chamber of the eye and an outflow end of the shunt is positioned between layers of Tenon's capsule.

Abstract: Described herein is the surprising discovery that ketone bodies protect cell and tissues from ionizing radiation. Based on this finding, methods of protecting animal tissue and cells from damage caused by radiation exposure are disclosed which include, contacting the tissue with a therapeutically effective amount of an agent including at least one ketone ester, thereby protecting the tissue from radiation damage. Ketone esters can be used to minimize, reduce and/or prevent tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage.

Abstract: This disclosure provides a thermocycler system for performing polymerase chain reaction. The thermocycler system can comprise a plurality of bus bars, a microplate, a clamp and a current application device in electrical communication with the bus bars. The clamp is suitable for forming a low resistance electrical connection between the microplate and an individual bus bar of the plurality of bus bars. In some instances, the clamp includes a spring-loaded pivot and a ram. Operation of the clamp forces the microplate into contact with the bus bar, or vice versa, to provide an electrical contact between the microplate and the bus bar. The microplate can comprise a substrate having a metallic material for heating samples, and a barrier layer disposed adjacent to the substrate.

Abstract: A tool having a pump-out unit, pumping unit, and NMR unit is disposed in a wellbore. On a pump-up cycle, after removing borehole fluids, a fluid is injected into a region of investigation. NMR measurements are made while fluid migrates into the region of investigation. On a production cycle, pressure is removed, allowing fluid to exit the formation while NMR measurements are made. A rate of fluid production is estimated using the time-dependent NMR measurements. Alternatively, the mass of a sample is measured. Fluid is injected into the sample and the mass of the injected sample is measured. Pressure is removed and the mass of the injected sample as the fluid migrates out of the sample is measured. The change in mass of the injected sample as the fluid migrates out of the sample is determined and a rate of fluid production is estimated using the determined change in mass.

Abstract: A terrestrial transceiver is described, which is operable for exchanging RF signals with communication satellites. The transceiver has a patch antenna sensitive to signals within an L-Band RF range and operable for providing a gain to the RF signals. A metallic reflector of a characteristic dimension is operable for shaping a pattern of the RF gain of the patch antenna. A printed circuit board assembly (PCBA) has a dielectric substrate, an electronic component disposed upon the substrate, and a hole penetrating the substrate and disposed substantially within a central region thereof. Based on the dimension characteristic of the reflector and on a positioning and/or a dimension of the hole, the RF gain diverges over an angle from a boresight of the patch antenna.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: Treatment methods and treatment fluids for increasing permeability of organic shale formations are described herein. The treatment method includes treating an organic shale formation with a treatment fluid. The treatment fluid includes a solvent that dissolves bitumen in the shale formation. After treating the shale formation with the treatment fluid, oil is recovered from the shale formation. By removing bitumen from pores and pore throats within the formation, the solvent increases permeability of the formation and allows mobile oil to flow more easily through the formation.

Abstract: Implanting an intraocular shunt into an eye can involve creating an opening in the cornea and positioning a shunt in the anterior chamber of the eye such that the shunt terminates between layers of Tenon's capsule, thereby facilitating fluid flow out of the anterior chamber into a space between the layers of Tenon's capsule.

Abstract: Embodiments disclosed herein relate to an apparatus for refining a liquid stream which includes a liquid carrier with a heavier waste and a lighter waste. The apparatus includes a first flow chamber, a second flow chamber, and plates. The first flow chamber is a cone structure and directs the liquid stream downwards in a first direction at a first velocity. The first velocity is greater than a settling velocity of a heavier waste in the liquid carrier. The second flow chamber directs the liquid carrier upwards in a second direction at a second velocity less than the settling velocity. The plates are in the second flow chamber and at a transition between the first and second flow chambers. The plates have an inclined geometry to cause laminar flow in the liquid stream to separate the heavier waste to a lower collection chamber and lighter waste to an upper collection reservoir.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: Embodiments disclosed herein relate to an apparatus for refining a liquid stream. The apparatus includes a first flow chamber, an inclined plate region, and a second flow chamber. The first flow chamber forms a first portion of an hourglass double cone structure and directs the liquid stream in a first direction at a first velocity. The inclined plate region includes inclined plates radiating outward from the hourglass double cone structure in a helical pattern. The inclined plate region directs the liquid carrier in a second direction opposite the first direction at a second velocity less than the first velocity forming a laminar flow condition in the liquid stream to separate heavy waste and light waste from the liquid stream. The second flow chamber forms a second portion of the hourglass double cone structure and directs the liquid stream to a liquid stream outlet.

Abstract: The subject disclosure provides compositions for reducing serum cholesterol and/or triglyceride levels in subjects. These compositions can comprise racemic ?-hydroxybutyrate or D-?-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic ?-hydroxybutyrate or ?-hydroxybutyrate, esters of D-?-hydroxybutyrate, oligomers of D-?-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol or R-1,3 butandiol alone and can be, optionally, administered in conjunction with a low fat diet to a subject.