Abstract: Disclosed are salts of C4-carboxylic acid-substituted and C4-carbonothioate-substituted tryptamine derivative compounds represented by chemical formula (I), wherein R4 is a carboxylic acid moiety or a derivative thereof, or a carbonothioate moiety or a derivative thereof; R3a and R3b are each independently a hydrogen atom, an alkyl group, or an aryl group; and Z is a counter-balancing anion; and pharmaceutical and recreational drug formulations containing the same. The pharmaceutical formulations may be used to treat brain neurological disorders.

Abstract: Methods and systems for grounding a rotor of an electric machine. The electric machine system includes a rotor shaft, a grounding cover coupled to an end of the rotor shaft, and a cam aligned with a rotational axis of the rotor shaft and electrically coupled to the grounding cover. The electric machine system further includes an end plate of a housing and a spring extending between the cam and an interior surface of the housing, where the grounding cover, the cam, and the spring are electrically conductive.

Abstract: A vehicle is provided with a transmission having an inductor assembly. The inductor assembly is mounted within the transmission such that it is directly cooled by transmission fluid through at least one of spraying, splashing and immersion. The transmission includes at least one gear that is configured to, when rotating, transmit torque between an input and output of the transmission and splash fluid onto the inductor assembly to cool the inductor assembly.

Abstract: Pharmaceutical formulations to prevent or treat hemorrhagic shock are provided. The pharmaceutical formulations comprise an oxygenation complement comprising a hemoglobin-based oxygen carried (HBOC) and blood plasma. Related methods to prepare the pharmaceutical preparations are also provided. Furthermore, methods to prevent or treat hemorrhagic shock are provided.

Abstract: Methods for making hemoglobin based blood substitute preparations and hemoglobin based blood substitute preparations. The methods involve preparing a low purity erythrocyte protein fraction comprising hemoglobin protein and endogenous non-hemoglobin protein complement, and chemically modifying the proteins in the protein fraction to form a cross-linked hemoglobin containing blood substitute preparation. The low purity erythrocyte protein preparation can contain from at least about 0.2% (mole/mole) up to about 20% (mole/mole) endogenous non-hemoglobin protein complement. At least about 90% (mole/mole) of the hemoglobin proteins can be cross-linked, so that the average molecular mass of cross-linked proteins comprising hemoglobin protein molecules in the preparation is at least about 300 kDa. The preparations can be used to prepare finished blood substitute formulations for in-vivo and ex-vivo use.

Abstract: Methods for making hemoglobin based blood substitute preparations and hemoglobin based blood substitute preparations. The methods involve preparing a low purity erythrocyte protein fraction comprising hemoglobin protein and endogenous non-hemoglobin protein complement, and chemically modifying the proteins in the protein fraction to form a cross-linked hemoglobin containing blood substitute preparation. The low purity erythrocyte protein preparation can contain from at least about 0.2% (mole/mole) up to about 20% (mole/mole) endogenous non-hemoglobin protein complement. At least about 90% (mole/mole) of the hemoglobin proteins can be cross-linked, so that the average molecular mass of cross-linked proteins comprising hemoglobin protein molecules in the preparation is at least about 300 kDa. The preparations can be used to prepare finished blood substitute formulations for in-vivo and ex-vivo use.

Abstract: Methods and systems for an electric motor-generator in a vehicle are provided. In one example, an electric motor-generator is provided that includes an engine interface configured to rotationally couple to a first engine, a transmission interface configured to rotationally couple to a first transmission of the first engine, and a rotor with a plurality of magnets at least partially surrounding a stator including a plurality of coils. The rotor is rotationally coupled to the engine interface and the transmission interface.

Abstract: A vehicle is provided with a transmission having an inductor assembly. The inductor assembly is mounted within the transmission such that it is directly cooled by transmission fluid through at least one of spraying, splashing and immersion. The transmission includes at least one gear that is configured to, when rotating, transmit torque between an input and output of the transmission and splash fluid onto the inductor assembly to cool the inductor assembly.

Abstract: A vehicle is provided with a transmission having an inductor assembly. The inductor assembly is mounted within the transmission such that it is directly cooled by transmission fluid through at least one of spraying, splashing and immersion. The transmission includes at least one gear that is configured to, when rotating, transmit torque between an input and output of the transmission and splash fluid onto the inductor assembly to cool the inductor assembly.

Abstract: Oxygenation constituents and finished oxygenation media, as well as methods of making oxygenation constituents and finished oxygenation media are provided. The oxygenation constituents comprise a hemoglobin preparation, and a red blood cell preparation. The oxygenation constituents comprise from about 10% to about 99% by weight hemoglobin of the hemoglobin preparation and the balance by weight hemoglobin of the oxygenation constituents comprise a red blood cell preparation. The finished oxygenation media comprise the oxygenation constituents and one or more other ingredients such as a diluent, or excipient. The finished oxygenation media can be used to ex-vivo preserve organs or tissue.

Abstract: Methods and systems for an electric motor-generator in a vehicle are provided. In one example, an electric motor-generator is provided that includes an engine interface configured to rotationally couple to a first engine, a transmission interface configured to rotationally couple to a first transmission of the first engine, and a rotor with a plurality of magnets at least partially surrounding a stator including a plurality of coils. The rotor is rotationally coupled to the engine interface and the transmission interface.

Abstract: Methods for making hemoglobin based blood substitute preparations and hemoglobin based blood substitute preparations. The methods involve preparing a low purity erythrocyte protein fraction comprising hemoglobin protein and endogenous non-hemoglobin protein complement, and chemically modifying the proteins in the protein fraction to form a cross-linked hemoglobin containing blood substitute preparation. The low purity erythrocyte protein preparation can contain from at least about 0.2% (mole/mole) up to about 20% (mole/mole) endogenous non-hemoglobin protein complement. At least about 90% (mole/mole) of the hemoglobin proteins can be cross-linked, so that the average molecular mass of cross-linked proteins comprising hemoglobin protein molecules in the preparation is at least about 300 kDa. The preparations can be used to prepare finished blood substitute formulations for in-vivo and ex-vivo use.

Abstract: A transmission assembly including a housing, an electric motor, and a baffle is provided. The housing may include first and second drainage channels. The electric motor may be disposed within the housing adjacent the drainage channels and a torque converter. The baffle may be disposed within the housing upon a housing inner surface, and may define an opening to the first and second drainage channels. The baffle may include a baffle flange sized for positioning adjacent the torque converter to minimize contact of oil within the housing to the torque converter. The housing may define first and second partition walls each partially extending over one of the first and second drainage channels. The baffle may further include first and second seal features each disposed at one of two baffle ends.

Abstract: A transmission assembly including a housing, an electric motor, and a baffle is provided. The housing may include first and second drainage channels. The electric motor may be disposed within the housing adjacent the drainage channels and a torque converter. The baffle may be disposed within the housing upon a housing inner surface, and may define an opening to the first and second drainage channels. The baffle may include a baffle flange sized for positioning adjacent the torque converter to minimize contact of oil within the housing to the torque converter. The housing may define first and second partition walls each partially extending over one of the first and second drainage channels. The baffle may further include first and second seal features each disposed at one of two baffle ends.

Abstract: An electro-magnetically actuated pawl clutch is adapted to establish a fixed overdrive ratio in a powersplit type hybrid gearing arrangement. The electro-magnetically actuated clutch includes a first race splined to the transmission input shaft and a second race integrally formed into a first gear that is supported for rotation about the input shaft. Electrical current in a non-rotating coil establishes a magnetic field in the first race. The magnetic field causes a set of pawls to pivot with respect to the first race and to engage a cam surface in the second race. The pawls and cams are designed such that, when engaged, the second race can rotate faster than the inner race but cannot rotate slower. The first gear meshes with a second gear fixed to the transmission output shaft.

Abstract: A transaxle and a parking actuator assembly are provided. The parking actuator assembly may include an actuator, a rack, and the biasing member. The actuator may include a pin biased towards an extended position. The rack may be configured to carry a parking rod and may define first and second ramped recesses each configured to receive the pin. The biasing member may be coupled with the rack and may be configured to bias the parking rod towards engagement with a parking mechanism.

Abstract: A vehicle is provided with a transmission having an inductor assembly. The inductor assembly is mounted within the transmission such that it is directly cooled by transmission fluid through at least one of spraying, splashing and immersion. The transmission includes at least one gear that is configured to, when rotating, transmit torque between an input and output of the transmission and splash fluid onto the inductor assembly to cool the inductor assembly.

Abstract: A vehicle electrical power system includes a variable voltage converter. The variable voltage converter includes an inductor assembly having a housing that defines a chamber containing dielectric fluid. An inductor is disposed within the chamber and is in contact with the fluid. The power system also includes a pump configured to circulate the dielectric fluid to cool the inductor.

Abstract: A vehicle is provided with a transmission having an inductor assembly. The inductor assembly is mounted within the transmission such that it is directly cooled by transmission fluid through at least one of spraying, splashing and immersion. The transmission includes at least one gear that is configured to, when rotating, transmit torque between an input and output of the transmission and splash fluid onto the inductor assembly to cool the inductor assembly.

Abstract: A transaxle and a parking actuator assembly are provided. The parking actuator assembly may include an actuator, a rack, and the biasing member. The actuator may include a pin biased towards an extended position. The rack may be configured to carry a parking rod and may define first and second ramped recesses each configured to receive the pin. The biasing member may be coupled with the rack and may be configured to bias the parking rod towards engagement with a parking mechanism.