Abstract: A securement device is provided. The securement device comprising: a ring comprising coplanar facing ends separated by a space; and a housing, a lock member positioned at least partially within the housing, wherein the lock member comprises a neck having a width less than the space, and a body having at least a portion with a width greater than the space; wherein the article is configured to adjust from a locked configuration to an unlocked configuration; the locked configuration preventing rotational translation of the ring through the housing; and the unlocked configuration allowing rotational translation of the ring through the housing.

Abstract: A securement device is provided. The securement device comprising: a ring comprising coplanar facing ends separated by a space; and a housing, a lock member positioned at least partially within the housing, wherein the lock member comprises a neck having a width less than the space, and a body having at least a portion with a width greater than the space; wherein the article is configured to adjust from a locked configuration to an unlocked configuration; the locked configuration preventing rotational translation of the ring through the housing; and the unlocked configuration allowing rotational translation of the ring through the housing.

Abstract: A genetically modified coccidian parasites wherein expression of phosphatidylthreonine synthase (PTS) is disrupted, a polynucleotide including a nucleotide sequence encoding a phosphatidylthreonine synthase (PTS) enzyme, which catalyzes the production of a lipid, phosphatidylthreonine (PtdThr). PtdThr is an exclusive, major and physiologically important lipid in selected coccidian parasites, which is required for a normal growth and virulence of coccidian parasites. Coccidian parasites, having the expression of PTS disrupted as described herein, are useful as vaccines. The phosphatidylthreonine synthase enzyme and the nucleotide encoding sequences thereof as well as the phosphatidylthreonine phospholipid can find use in diagnostic methods and diagnostic kits or in vaccine and drug development applications.

Abstract: The present invention relates to uses of cystatins derived from nematodes and to a method of screening using such cystatin. The present invention also relates to methods of treatment and/or prevention of an allergic and/or autoimmune disease in a patient, using a cystatin derived from a nematode.