Patents by Inventor Richard M. Harland

Richard M. Harland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified dorsal tissue affecting factor and compositions
    Publication number: 20030129703
    Abstract: Described are modified Noggin muteins, compositions comprising the muteins, and DNA or RNA sequences comprising coding (sense) or antisense sequences for the muteins.
    Type: Application
    Filed: December 19, 2002
    Publication date: July 10, 2003
    Inventors: Aris Economides, Neil E. Stahl, Richard M. Harland
  • Nucleic acid molecules encoding modified dorsal tissue affecting factor
    Patent number: 6500640
    Abstract: Described are modified Noggin muteins, compositions comprising the muteins, and DNA or RNA sequences comprising coding (sense) or antisense sequences for the muteins.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: December 31, 2002
    Assignees: Regeneron Pharmaceuticals, Inc., Regents of the University of California
    Inventors: Aris Economides, Neil E. Stahl, Richard M. Harland
  • Dorsal tissue affecting factor and compositions
    Publication number: 20020102643
    Abstract: Novel dorsal growth inducing factors, complexes including the factors, and DNA or RNA coding sequences for the factors are described.
    Type: Application
    Filed: July 2, 2001
    Publication date: August 1, 2002
    Inventors: David M. Valenzuela, Nancy Y. Ip, Henryk D. Cudny, George D. Yancopoulos, Richard M. Harland, William C. Smith, Teresa Lamb, Anne Knecht
  • Dorsal tissue affecting factor and compositions
    Patent number: 6277593
    Abstract: Novel dorsal growth inducing factors, complexes including the factors, and DNA or RNA coding sequences for the factors are described.
    Type: Grant
    Filed: October 7, 1998
    Date of Patent: August 21, 2001
    Assignees: Regeneron Pharmaceuticals, Inc., Regents of the Univ. of California
    Inventors: David M. Valenzuela, Nancy Y. Ip, Henryk D. Cudny, George D. Yancopoulos, Richard M. Harland, William C. Smith, Teresa Lamb, Anne Knecht
  • Modified noggin polypeptide and compositions
    Patent number: 6075007
    Abstract: Described are modified Noggin muteins, compositions comprising the muteins, and DNA or RNA sequences comprising coding (sense) or antisense sequences for the muteins.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: June 13, 2000
    Assignees: Regeneron Pharmaceuticals, Inc., Regents of the Univ. of California
    Inventors: Aris Economides, Neil E. Stahl, Richard M. Harland
  • Nucleic acids encoding a neural tissue affecting factor
    Patent number: 6008339
    Abstract: A functional peptide is encoded by SEQ ID NO:1. This peptide is capable of inducing dorsal and neural tissue development in vertebrates. The peptide is a member of the TGF-.beta. superfamily, and can be prepared in therapeutic applications to treat congenital conditions or degenerative disorders of the nervous system and in compositions useful for inducing growth of bone.
    Type: Grant
    Filed: August 22, 1995
    Date of Patent: December 28, 1999
    Assignee: The Regents of the University of California
    Inventors: Richard M. Harland, William C. Smith
  • Human dorsal tissue affecting factor (noggin) and nucleic acids encoding same
    Patent number: 5843775
    Abstract: Novel dorsal growth inducing factors, complexes including the factors, and DNA or RNA coding sequences for the factors are described.
    Type: Grant
    Filed: September 22, 1995
    Date of Patent: December 1, 1998
    Assignees: Regeneron Pharmaceuticals, Inc., Regents of University of California
    Inventors: David M. Valenzuela, Nancy Y. Ip, Henryk D. Cudny, George D. Yancopoulos, Richard M. Harland, William C. Smith, Teresa Lamb, Anne Knecht
  • Hybridoma cell lines and antibodies that bind noggin
    Patent number: 5821124
    Abstract: Novel dorsal growth inducing factors, complexes including the factors, and DNA or RNA coding sequences for the factors are described. Hybridoma cell lines and antibodies that bind to the dorsal growth inducing factor noggin, having the amino acid sequence set forth in SEQ ID NO:2, are also described.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 13, 1998
    Assignees: Regeneron Pharmaceuticals, Inc., Regents of Univ. of California
    Inventors: David M. Valenzuela, George D. Yancopoulos, Richard M. Harland, William C. Smith
  • Dorsal tissue affecting factor (noggin) and compositions comprising same
    Patent number: 5670481
    Abstract: A novel and soluble polypeptide that is highly conserved among vertebrates has been discovered, which is designated "noggin." The properties of noggin include dorsal growth inducing activity. Noggin and activin act synergistically to produce dorsal mesoderm. Noggin's cDNA has been cloned. Several expression systems have been successfully used to express biologically active noggin. Amino acid sequences representing completely conserved portions as between frog noggin and mouse noggin are:QMWLWSQTFCPVLY (SEQ ID NO:3);RFWPRYVKVGSC (SEQ ID NO:4);SKRSCSVPEGMVCK (SEQ ID NO:5);LRWRCQRR (SEQ ID NO:6); and,ISECKCSC (SEQ ID NO:7).
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: September 23, 1997
    Assignee: The Regents of the University of California
    Inventors: Richard M. Harland, William C. Smith