Abstract: A syringe is described including a plastic barrel having a unitary needle extending from one end thereof which is normally shielded by a nasal tip-seal cap. A plunger is movably mounted in the barrel for aspirating the contents of the barrel or for drawing liquid into the barrel. The nasal tip-seal cap may be deflected or compressed with respect to the shielded needle so that the needle will pierce therethrough to enable the needle to be in communication with the interior of a pharmaceutical vial. The method of using the syringe of the invention to nasally vaccinate an animal or nasally vaccinate a human is also described.

Abstract: A syringe is described which is used in an improved method of vaccinating an animal. The syringe includes a one-piece barrel and needle comprised of a suitable injection molded plastic such as a polycarbonate material with the needle normally being enclosed or shielded by a flexible nasal tip-cap seal. The syringe is filled with a freeze-dried vaccine at the factory and is shipped to the point of use in a sealed pouch. The nasal tip-cap seal is placed in engagement with the cap or cover of a vial containing a diluent such as sterile water. The syringe is moved relative to the vial to cause the needle to pierce through the cover of the vial so that the distal end of the needle is in communication with the interior of the vial. The contents of the vial are then drawn inwardly into the syringe.

Abstract: A closure for closing plastic bags comprising a truncated, hollow cone having an opening extending therethrough for receiving the bunched neck of a plastic bag or the like. The cone is provided with a plurality of spaced-apart gripping fingers which engage the bunched neck of the plastic bag to prevent the cone from becoming detached from the bag. An optional weak section is provided in the closure to enable the closure to be selectively opened to remove the closure from the bag.