Patents by Inventor Richard M. Jack

Richard M. Jack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TREATING MYELOPROLIFERATIVE DISORDERS
    Publication number: 20180318303
    Abstract: In part, the disclosure relates to methods of treating myeloproliferative disorders by administering one or more Serum Amyloid Protein (SAP) proteins. In certain aspects, the method further comprises monitoring treatment efficacy by measuring change in mutant allele burden. In certain aspects, the disclosure relates to methods of treating myelofibrosis in patient sub-populations who carry myelofibrosis-associated mutations in some of their cells by administering an SAP protein.
    Type: Application
    Filed: April 15, 2016
    Publication date: November 8, 2018
    Inventors: Elizabeth Trehu, Richard M. Jack
  • Conjugates comprising galactose alpha 1,3 galactosyl epitopes and methods of using same
    Publication number: 20020160964
    Abstract: This invention provides conjugates useful for xenotransplantation which comprise a galactose &agr;1,3 galactosyl (&agr;Gal) epitope conjugated to a valency platform molecule, preferably a chemically defined valency platform molecule which allows precise valency. The invention also provides compositions comprising these conjugates, and methods (such as methods for inducing tolerance) using these conjugates and compositions.
    Type: Application
    Filed: April 11, 2002
    Publication date: October 31, 2002
    Inventors: Richard M. Jack, David S. Jones, Lin Yu
  • Methods and formulations for reducing circulating antibodies
    Publication number: 20020155107
    Abstract: The invention provides methods for reducing circulating levels of antibodies, particularly disease-associated antibodies. The methods entail administering effective amounts of epitope-presenting carriers to an individual. In other embodiments, ex vivo methods for reducing circulating levels of antibodies are provided which employ epitope-presenting carriers.
    Type: Application
    Filed: April 3, 2002
    Publication date: October 24, 2002
    Inventors: Steven B. Engle, Richard M. Jack, David S. Jones, Lin Yu
  • Conjugates comprising galactose &agr;1,3 galactosyl epitopes and methods of using same
    Patent number: 6399578
    Abstract: This invention provides conjugates useful for xenotransplantation which comprise a galactose &agr;1,3 galactosyl (&agr;Gal) epitope conjugated to a valency platform molecule, preferably a chemically defined valency platform molecule which allows precise valency. The invention also provides compositions comprising these conjugates, and methods (such as methods for inducing tolerance) using these conjugates and compositions.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: June 4, 2002
    Assignee: La Jolla Pharmaceutical Company
    Inventors: Richard M. Jack, David S. Jones, Lin Yu
  • Methods and formulations for reducing circulating antibodies
    Publication number: 20010010818
    Abstract: The invention provides methods for reducing circulating levels of antibodies, particularly disease-associated antibodies. The methods entail administering effective amounts of epitope-presenting carriers to an individual. In other embodiments, ex vivo methods for reducing circulating levels of antibodies are provided which employ epitope-presenting carriers.
    Type: Application
    Filed: January 18, 2001
    Publication date: August 2, 2001
    Inventors: Steven B. Engle, Richard M. Jack, David S. Jones, Lin Yu
  • Complement components and binding ligands in fertility
    Patent number: 5665556
    Abstract: Methods for detecting and isolating acrosome-reacted sperm and complement receptor-bearing oocytes using the complement component C3, fragments, or variants thereof, antibodies to a complement receptor, or antibodies to C3, are disclosed. These methods have application in the assessment of fertility, in the preparation of sperm or oocytes for in vitro fertilization or for gamete intrafallopian tube transfer, in promoting or inhibiting fertilization in vitro and in vivo, and in diagnosing and treating infertility.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: September 9, 1997
    Assignee: Brigham and Women's Hospital
    Inventors: Deborah J. Anderson, Peter M. Johnson, Richard M. Jack
  • Complement components and binding ligands in fertility
    Patent number: 5474927
    Abstract: Methods for detecting and isolating acrosome-reacted sperm and complement receptor-bearing oocytes using the complement component C3, fragments, or variants thereof, antibodies to a complement receptor, or antibodies to C3, are disclosed. These methods have application in the assessment of fertility, in the preparation of sperm or oocytes for in vitro fertilization or for gamete intrafallopian tube transfer, in promoting or inhibiting fertilization in vitro and in vivo, and in diagnosing and treating infertility.
    Type: Grant
    Filed: October 19, 1993
    Date of Patent: December 12, 1995
    Assignee: Brigham and Women's Hospital
    Inventors: Deborah J. Anderson, Peter M. Johnson, Richard M. Jack