Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLPP), and/or congenital erythropoietic porphyria (CEP), and related syndromes thereof.

Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLPP), and/or congenital erythropoietic porphyria (CEP), and related syndromes thereof.

Abstract: An automated method that generates crowd-sourced event notifications includes: retrieving sensor data from mobile devices; detecting events based on the retrieved sensor data; and generating a set of summary nodes based on the events, where each summary node is associated with multiple events. A system that generates crowd-sourced event notifications includes: multiple mobile devices, each having at least one sensor, each mobile device identifies events using calculations based on sensor data and generates a notification for each identified event; and an analytics server that generates a set of summary nodes based on the identified events, each summary node associated with multiple events. An automated method that generates event notifications includes: retrieving sensor data; calculating a set of statistical values based on the sensor data; comparing the statistical values to at least one threshold; and generating an event notification when the threshold is exceeded by any of the statistical values.

Abstract: An automated method that generates crowd-sourced event notifications includes: retrieving sensor data from mobile devices; detecting events based on the retrieved sensor data; and generating a set of summary nodes based on the events, where each summary node is associated with multiple events. A system that generates crowd-sourced event notifications includes: multiple mobile devices, each having at least one sensor, each mobile device identifies events using calculations based on sensor data and generates a notification for each identified event; and an analytics server that generates a set of summary nodes based on the identified events, each summary node associated with multiple events. An automated method that generates event notifications includes: retrieving sensor data; calculating a set of statistical values based on the sensor data; comparing the statistical values to at least one threshold; and generating an event notification when the threshold is exceeded by any of the statistical values.

Abstract: A cloud estimator tool can be configured to analyze a server configuration profile that characterizes hardware parameters for a node of a potential cloud computing environment and a load profile that characterizes computing load parameters for the potential cloud computing environment to generate a cloud computing configuration for the potential cloud computing environment. The cloud estimator tool determines a performance estimate and a cost estimate for the cloud computing configuration based on the hardware parameters and the computing load parameters characterized in the server configuration profile and the load profile.

Abstract: Various systems and methods for tracking the usage of shipping equipment are disclosed. An environmental benefit associated with the use of the shipping equipment may be determined and corresponding environment credits may be awarded based on the environmental benefit. In some embodiments, the movement and, optionally, the environmental conditions of a shipment or shipping equipment may be tracked as the shipment progresses from an originating location to a destination location. In some embodiments, a shipment or shipping equipment may be tracked by generating a data object that is transported with the shipment. The data object may be updated with the route, environmental conditions and timing of the transportation of the shipment. The data object may be transferred to various devices and locations for transport or storage with the shipment or shipping equipment. Data recorded in the data object may then be used to deliver environmental credits based on the stored data.

Abstract: Visual stimuli provided by surfaces of an object are selected based on anticipated viewing angles and activities associated with the viewing angles. Such surfaces can be selected based on identification and observation of significant events in a selected activity. Object zones so identified can be provided with functional ornamentation to enhance performance of one or more activities. Functional ornamentation can be based on gray level contrast, color contrast, or other visual characteristics. Dynamic functional ornamentation in which visual characteristics are a function of ornamentation motion, placement, distortion, of viewing angle can be used. In some examples, almost periodic patterns can be used, and the almost periodic patterns defined with a plurality of tiles.

Abstract: Dynamic visual indicators such as counter-predictive indicators are applied to apparel and apparatus for activities such as athletics. The counter-predictive indicators are configured to provide an indication of wearer/user orientation or anticipated future movement that differs from a true orientation or actual movement. Alternatively, the predictive indicators can be provided to reinforce or heighten perception of wearer/user orientation or anticipated future movement. In some examples, dynamic visual indicators provide apparent body axes that are tilted or displaced from a wearer's actual body axis. Such dynamic visual indicators can be selected based on measured responses to activity specific images or events.

Abstract: Fully automated modular analytical systems with integrated instrumentation for analysis of biopolymer samples, such as nucleic acids, proteins, peptides and carbohydrates, are provided. Analytical methods of detection and analysis, such as mass spectrometry, radiolabeling, mass tags, chemical tags and fluorescence chemiluminescence, are integrated with robotic technology and automated chemical reaction systems to provide a high-throughput, accurate Automated Process Line (APL).

Abstract: A fully automated modular analytical system integrates instrumentation to permit analysis of biopolymer samples. The samples include, but are not limited to, all biopolymers, e.g., nucleic acids, proteins, peptides and carbohydrates. The system integrates analytical methods of detection and analysis, e.g., mass spectrometry, radiolabeling, mass tags, chemical tags, fluorescence chemiluminescence, and the like, with robotic technology and automated chemical reaction systems to provide a high-throughput, accurate Automated Process Line (APL).

Abstract: An improved method of treating immune cell mediated systemic diseases, particularly T and B cell mediated diseases, is provided by increasing the systemic exposure, or bioavailibility, of a therapeutic protein. Such therapeutic protein is selected from the group consisting of a monoclonal antibody, a soluble receptor and a soluble ligand which binds to an antigen expressed on the surface of an immunce cell.

Abstract: A hand-holdable viewer having a viewing end and a viewing axis, along the latter of which a transparent display is disposed. The viewer includes a Global Positioning System receiver (GPS) and a microprocessor connected to the GPS. The viewer is also provided with a slide holder for receiving a map slide having a map image and a EEPROM containing information about the geographical extent of the map image. When a map slide is inserted into the slide holder, it is aligned with the display, and so one is superimposed on the other, when viewed through the viewing end. The microprocessor reads the EEPROM and checks the GPS to determine whether the current position of the device is within the geographical extent of the map image. If this is so, the current position appears on the display. The EEPROM may also contain information about waypoints and routes which have previously been downloaded from a personal computer, or the like.

Abstract: A football-like projectile having a central longitudinal bore includes a weighted insert in the bore to concentrate the weight of the projectile interiorly of the ball about the longitudinal axis. The insert is provided with a longitudinal flow passage to permit air flow hrough the insert and the bore when the ball is in flight.

Abstract: A football or other projectile is stabilized in flight by weighted material that responds to spinning of the football about its major axis by moving radially outward to become evenly distributed about that axis. In a preferred embodiment, two annular tubes, concentrically disposed about the major axis, encircle the ball at opposite sides of a plane containing the minor axis of the ball. The weighted material, in the form of beads, liquid, etc., is contained within the tubes and is flung radially outward as the ball spins.

Abstract: A new cultivar of Prunus avium, ‘SPC103’, characterized by its very late harvest season, its flowers that are self-fertile, its intermediate to high precocity of fruit bearing, its spreading growth habit with horizontal one year-old shoots, its fruit skin and flesh that is dark red-purple in color with juice that is high in sweetness, and its firm and moderately juicy fruit that is kidney to cordate in shape.

Abstract: A new cultivar of Prunus avium, ‘13S2101’, characterized by its very late harvest season, its flowers that are self-fertile, its moderate precocity of fruit bearing, its spreading growth habit with horizontal one year-old shoots, its fruit skin and flesh that is red color with juice that is high in sweetness, and its firm fruit that is elongate to cordate in shape.

Abstract: A new cultivar of Prunus avium, ‘SPC136’, characterized by its mid-season fruit harvest, its flowers that are not self-fertile, lateness of bloom, its intermediate precocity of fruit bearing, its upright growth habit, its fruit skin that is wine red in color and flesh that is dark red to black in color, its large flowers with wide petals, and its firm, very large, kidney-shaped fruit.

Abstract: A new cultivar of apple tree named ‘8S5505’ that is characterized by its fruit that is flavorful with aromatic tropical notes, its fruit that is crisp, its fruit that is juicy, its fruit with excellent storage life, fruit with excellent shelf life, its trees with strong lateral growth, its high disease resistance to ‘apple scab’ (Venturia inaequalis) due to the presence of the VF gene and its mid-season bloom period (similar timing to Golden Delicious).