Abstract: Provided herein, in some embodiments, are methods and composition for treating cancer in a subject. The methods may include administering to the subject a nucleic acid encoding MIP3? fused to a cancer antigen, administering to the subject a CpG oligodeoxynucleotide, administering to the subject interferon alpha (IFN?), and administering to the subject 5-aza-2?-deoxycytidine (Aza), in effective amounts to treat the cancer.

Abstract: A system of Ocean-based barges following slow speed annual migration patterns that can net more incident solar energy, per unit area, than ever previously disclosed. This system makes use of solar radiant energy, seawater, and air to make most of the fuels/chemicals necessary for human life. These chemicals and/or fuels can then be efficiently distributed anywhere in the World by use of slow speed/low drag force travel, ocean currents, and/or transiting cargo ships. This system can power the entire Worlds global shipping industry, serve as an international decentralized energy grid, and/or provide a stored renewable energy reservoir of 100+ years.

Abstract: The present invention provides heavy chain immunoglobulins of the VHH type or fragment thereof having affinity for a target antigen of interest, including glycoprotein D2 (gD2) of HSV-2 or antigen thereof, and for envelope proteins of HIV-1 or an antigen thereof linked to Pseudomonas exotoxin A or functional fragments thereof. Also included are multimeric forms of the immunoglobulins and their use in the prevention and/or treatment of HSV2 and/or HIV-1.

Abstract: Provided herein, in some embodiments, are methods and composition for treating cancer in a subject. The methods may include administering to the subject a nucleic acid encoding MIP3? fused to a cancer antigen, administering to the subject a CpG oligodeoxynucleotide, administering to the subject interferon alpha (IFN?), and administering to the subject 5-aza-2?-deoxycytidine (Aza), in effective amounts to treat the cancer.

Abstract: The present invention provides heavy chain immunoglobulins of the VHH type or fragment thereof having affinity for a target antigen of interest, including glycoprotein D2 (gD2) of HSV-2 or antigen thereof, and for envelope proteins of HIV-1 or an antigen thereof linked to Pseudomonas exotoxin A or functional fragments thereof. Also included are multimeric forms of the immunoglobulins and their use in the prevention and/or treatment of HSV2 and/or HIV-1.

Abstract: Provided herein are methods, compositions, and kits for preventing, inhibiting, reducing the severity of, or treating a disease or condition. A pharmaceutical composition provided herein can comprise a nucleic acid sequence encoding an antigen fused to an immune cell product, e.g., MIP-3?, and an adjuvant. The antigen can be from a bacteria, virus, fungus, parasite, or cancer. The antigen can be an Alzheimer's disease antigen.

Abstract: Melanoma vaccines are provided. Compositions and methods are provided for making and using melanoma vaccine constructs, alone, or in combination with at least one adjuvant. Compositions and methods can be in combination with other therapeutic compositions. The melanoma vaccine constructs of DNA or protein.

Abstract: The present invention provides heavy chain immunoglobulins of the VHH type or fragment thereof having affinity for a target antigen of interest, including glycoprotein D2 (gD2) of HSV-2 or antigen thereof, and for envelope proteins of HIV-1 or an antigen thereof linked to Pseudomonas exotoxin A or functional fragments thereof. Also included are multimeric forms of the immunoglobulins and their use in the prevention and/or treatment of HSV2 and/or HIV-1.

Abstract: Protein-based vaccines against infectious agents, including malaria and Zika virus, are described. The protein-based vaccines include an antigen domain and an immature dendritic cell targeting domain and are administered in combination with an adjuvant.

Abstract: Disclosed herein are DNA-based vaccines against amyloid ? peptide for use in treating and alleviating Alzheimer's Disease and related conditions. A DNA construct comprising DNA encoding one or more amyloid ? peptides, such as amino acids 1-11 of A?, and DNA encoding a hepatitis B antigens, is administered with an adjuvant or by electroporation. The vaccine can also be formulated using a fusion protein expressed by the disclosed DNA, in combination with an adjuvant.

Abstract: The present invention provides heavy chain immunoglobulins of the VHH type or fragment thereof having affinity for a target antigen of interest, including glycoprotein D2 (gD2) of HSV-2 or antigen thereof, and for envelope proteins of HIV-1 or an antigen thereof linked to Pseudomonas exotoxin A or functional fragments thereof. Also included are multimeric forms of the immunoglobulins and their use in the prevention and/or treatment of HSV2 and/or HIV-1.

Abstract: Disclosed herein are DNA-based vaccines against amyloid ? peptide for use in treating and alleviating Alzheimer's Disease and related conditions. A DNA construct comprising DNA encoding one or more amyloid ? peptides, such as amino acids 1-11 of A?, and DNA encoding a hepatitis B antigens, is administered with an adjuvant or by electroporation. The vaccine can also be formulated using a fusion protein expressed by the disclosed DNA, in combination with an adjuvant.

Abstract: Disclosed herein are nucleic acid-based vaccines against malaria and other conditions. A DNA construct comprising nucleic acid encoding one or more pathogen proteins, such as malaria parasite proteins, nucleic acid encoding a dendritic cell ligand, and a linker polynucleotide, is administered with an adjuvant and/or by electroporation to achieve in vivo results that are not achieved with the vaccine components alone. The vaccine can also be formulated using a fusion protein expressed by the disclosed nucleic acid, in combination with an adjuvant.

Abstract: This system provides a wide range of smooth and precisely controlled low and high speeds for pan-tilt-zoom surveillance cameras, in which a brushless motor is controlled by a Microcontroller in a low speed mode by sinusoidal synchronous commutation, in a high speed mode by block commutation, and in a transition phase from the low speed mode to the high speed mode by modulating integrated pulse-width modulation (PWM) square waves with sine waves. PID and lookup table registers are used by a microcontroller for a smooth transition from high speed mode to low speed mode, and from low speed mode to high speed mode, phase locking a sine position during transitions, in order to give a surveillance camera an ability to quickly move from one target to another at up to 100 degrees per second yet track objects that are moving very slowly.

Abstract: Provided herein are methods, compositions, and kits for preventing, inhibiting, reducing the severity of, or treating a disease or condition. A pharmaceutical composition provided herein can comprise a nucleic acid sequence encoding an antigen fused to an immune cell product, e.g., MIP-3?, and an adjuvant. The antigen can be from a bacteria, virus, fungus, parasite, or cancer. The antigen can be an Alzheimer's disease antigen.

Abstract: A method and apparatus wherein the method includes the steps of generating a globally unique identifier (GUID) for a security system appliance, saving a public key and private key of the security system appliance in a memory of the security system appliance, a manufacturer of the security system appliance generating a signed version of the GUID and the public key, saving the signed version of the GUID and public key in the memory of the security system appliance, the security system appliance sending a registration message including the signed version of the GUID and public key to a security system server and the security system server authenticating the security system appliance using the signed version of the GUID and public key of the security system appliance and a public key of the manufacturer.

Abstract: A method and apparatus wherein the method includes the steps of generating a globally unique identifier (GUID) for a security system appliance, saving a public key and private key of the security system appliance in a memory of the security system appliance, a manufacturer of the security system appliance generating a signed version of the GUID and the public key, saving the signed version of the GUID and public key in the memory of the security system appliance, the security system appliance sending a registration message including the signed version of the GUID and public key to a security system server and the security system server authenticating the security system appliance using the signed version of the GUID and public key of the security system appliance and a public key of the manufacturer.

Abstract: Disclosed herein are DNA-based vaccines against amyloid ? peptide for use in treating and alleviating Alzheimer's Disease and related conditions. A DNA construct comprising DNA encoding one or more amyloid ? peptides, such as amino acids 1-11 of A?, and DNA encoding a hepatitis B antigens, is administered with an adjuvant or by electroporation. The vaccine can also be formulated using a fusion protein expressed by the disclosed DNA, in combination with an adjuvant.

Abstract: Provided herein are methods, compositions, and kits for preventing, inhibiting, reducing the severity of, or treating a disease or condition. A pharmaceutical composition provided herein can comprise a nucleic acid sequence encoding an antigen fused to an immune cell product, e.g., MIP-3?, and an adjuvant. The antigen can be from a bacteria, virus, fungus, parasite, or cancer. The antigen can be an Alzheimer's disease antigen.

Abstract: Provided herein are methods, compositions, and kits for preventing, inhibiting, reducing the severity of, or treating a disease or condition. A pharmaceutical composition provided herein can comprise a nucleic acid sequence encoding an antigen fused to an immune cell product, e.g., MIP-3?, and an adjuvant. The antigen can be from a bacteria, virus, fungus, parasite, or cancer. The antigen can be an Alzheimer's disease antigen.