Patents by Inventor Richard Maser

Richard Maser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSGENIC MOUSE MODELS SUPPORTING HUMAN INNATE IMMUNE FUNCTION
    Publication number: 20230340524
    Abstract: The present disclosure provides immunodeficient NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG™) mouse models that comprise an inactivated mouse Flt3 allele and, in some models, additional genetic modifications. These mouse models useful, for example, for superior engraftment of diverse hematopoietic lineages and for immune-oncology, immunology and infectious disease studies.
    Type: Application
    Filed: July 7, 2021
    Publication date: October 26, 2023
    Applicant: The Jackson Laboratory
    Inventors: Anna Karolina Palucka, Chun l. Yu, Jacques Banchereau, Richard Maser
  • TRANSGENIC MOUSE MODEL EXPRESSING HUMAN HLA-A201 RESTRICTION GENE
    Publication number: 20230270085
    Abstract: The present disclosure provides an immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG™) mouse models that comprise an inactivated mouse Flt3 allele, a nucleic acid encoding human interleukin 3 (IL3), a nucleic acid encoding human granulocyte/macrophage-stimulating factor (GM-CSF), a nucleic acid encoding human stem cell factor (SCF), and a HLA-A2/H2-D/B2M transgene encoding (i) a human B2-microglubulin (B2M) covalently linked to MHC class 1, alpha 1, and alpha2 binding domains of a human HLA-A2.1 gene and (ii) alpha3 cytoplasmic and transmembrane domains of murine H2-db.
    Type: Application
    Filed: July 7, 2021
    Publication date: August 31, 2023
    Applicant: The Jackson Laboratory
    Inventors: Anna Karolina Palucka, Chu l. Yu, Jacques Banchereau, Richard Maser, Leonard D. Shultz
  • COMPOSITIONS AND METHODS FOR CANCER GENE DISCOVERY
    Publication number: 20110030074
    Abstract: The present invention features transgenic non-human mammalian animals being genetically modified to develop cancer. The invention also relates to methods for identifying genes or genetic elements that are potentially related to human cancers using an chromosomally unstable animal model. Information on such genetic alterations can be used to predict cancer therapeutic outcomes and to stratify patient populations to maximize therapeutic efficacy.
    Type: Application
    Filed: May 21, 2008
    Publication date: February 3, 2011
    Inventors: Ronald A. Depinho, Lynda Chin, Richard Maser