Abstract: A system and method is provided for identification, quantification, and analysis of risks within a supply chain infrastructure. A combination of risk event data, risk interaction definition, and risk assignment hierarchy is used to dynamically model the expected impact of risk to pre-defined performance measures within the system. The dynamic modeling is carried out with the help of the Monte Carlo simulation engine.

Abstract: This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors, particularly ubiquitin ligase inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved, such as signal transduction pathways. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a compound or pharmaceutical composition according to the invention. Particularly, the compounds and pharmaceutical compositions are useful to inhibit the ubiquitin ligase activity of TRAF6.