Patents by Inventor Richard Maurice Walmsley

Richard Maurice Walmsley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genotoxicity Testing
    Publication number: 20080064053
    Abstract: A recombinant vector comprises a recombinant DNA molecule comprising a DNA sequence that encodes a light emitting reporter protein. The DNA sequence is operatively linked to a regulatory element arranged to activate expression of the DNA sequence in response to DNA damage. When used to transform a cell, the vector does not substantially alter the sensitivity of the cell to geneticin, when compared to the sensitivity of the cell which has not been transformed with the vector.
    Type: Application
    Filed: July 30, 2004
    Publication date: March 13, 2008
    Inventors: Richard Maurice Walmsley, Nicholas Billinton
  • Detection of DNA damaging agents
    Patent number: 7049071
    Abstract: Recombinant DNA molecules comprising a regulatory element that activates gene expression in response to DNA damage operatively linked to a DNA sequence that encodes a light emitting reporter protein, recombinant vectors containing such DNA molecules and cells containing the DNA molecules or recombinant vectors. A method of detecting for the presence of an agent that causes or potentiates DNA damage is also disclosed which involves subjecting the above-described cells to a putative DNA damaging agent and monitoring the expression of the light emitting reporter protein from the cell.
    Type: Grant
    Filed: September 16, 2002
    Date of Patent: May 23, 2006
    Assignee: University of Manchester Institute of Science and Technology
    Inventors: Richard Maurice Walmsley, Wolf-Dietrich Heyer
  • Detection of DNA damaging agents
    Publication number: 20030049690
    Abstract: Recombinant DNA molecules comprising a regulatory element that activates gene expression in response to DNA damage operatively linked to a DNA sequence that encodes a light emitting reporter protein, recombinant vectors containing such DNA molecules and cells containing the DNA molecules or recombinant vectors. A method of detecting for the presence of an agent that causes or potentiates DNA damage is also disclosed which involves subjecting the above-described cells to a putative DNA damaging agent and monitoring the expression of the light emitting reporter protein from the cell.
    Type: Application
    Filed: September 16, 2002
    Publication date: March 13, 2003
    Applicant: Gentronix Limited
    Inventors: Richard Maurice Walmsley, Wolf-Dietrich Heyer
  • Green fluorescent protein
    Patent number: 6509161
    Abstract: A method of distinguishing between fluorescent light emitted by green fluorescent protein and fluorescent light emitted by auto-fluorescent molecules, the method comprising: using plane-polarised light to illuminate a sample containing green fluorescent protein and auto-fluorescent molecules; detecting the intensity of fluorescent light that is emitted with a first polarisation from the sample; detecting the intensity of fluorescent light that is emitted with a second polarisation from the sample; and subtracting a first of said detected intensities from a second of said detected intensities to obtain a difference signal.
    Type: Grant
    Filed: February 29, 2000
    Date of Patent: January 21, 2003
    Assignee: Gentronix Limited
    Inventors: Michael Gordon Barker, Nicholas Billinton, Nicholas John Goddard, Richard Maurice Walmsley, Andrew William Knight, Peter Robert Fielden
  • Detection of DNA damaging agents
    Patent number: 6489099
    Abstract: Recombinant DNA molecules comprising a regulatory element that activates gene expression in response to DNA damage operatively linked to a DNA sequence that encodes a light emitting reporter protein, recombinant vectors containing such DNA molecules and cells containing the DNA molecules or recombinant vectors. A method of detecting for the presence of an agent that causes or potentiates DNA damage is also disclosed which involves subjecting the above-described cells to a putative DNA damaging agent and monitoring the expression of the light emitting reporter protein from the cell.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: December 3, 2002
    Assignee: Gentronix Limited
    Inventors: Richard Maurice Walmsley, Wolf Dietrich Heyer