Patents by Inventor Richard Mazurchuk

Richard Mazurchuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
    Patent number: 7897140
    Abstract: Novel tetrapyrollic water soluble photosensitizing and imaging compounds and the methods of treating and imaging hyperproliferative tissue, e.g. tumors and hypervacularized tissue such as found in macular degeneration. Broadly, the compounds are tetrapyrollic photosensitizer compounds where the tetrapyrollic compound is a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide having 3 to 6 —CH2CONHphenylCH2CH(N(CH2COOH)2))(CH2N(CH2COOH)(CH2CH2N(CH2COOH)2)) groups or esters thereof or complexes thereof with gadolinium(III).
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: March 1, 2011
    Assignee: Health Research, Inc.
    Inventors: Ravindra K. Pandey, Lalit Goswami, Joseph Spernyak, Peter Kanter, Richard Mazurchuk
  • Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium
    Patent number: 7744854
    Abstract: This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to identify an optimal time for administration of a chemotherapeutic agent. This invention also provides a method to determine whether or not a tumor is likely to be a responder to chemotherapy. The method comprises administration of a selenium compound to an individual and determining whether or not an increase in TVM is observed. An increased TVM following administration of selenium is an indication that the tumor will likely respond the chemotherapy.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: June 29, 2010
    Assignee: Health Research, Inc.
    Inventors: Youcef M. Rustum, Arup Bhattacharya, Karoly Toth, Harry K. Slocum, Rami G. Azrak, Sreenivasulu Chintala, Mukund Seshadri, Richard Mazurchuk
  • Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium
    Publication number: 20080019919
    Abstract: This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to identify an optimal time for administration of a chemotherapeutic agent. This invention also provides a method to determine whether or not a tumor is likely to be a responder to chemotherapy. The method comprises administration of a selenium compound to an individual and determining whether or not an increase in TVM is observed. An increased TVM following administration of selenium is an indication that the tumor will likely respond the chemotherapy.
    Type: Application
    Filed: March 23, 2007
    Publication date: January 24, 2008
    Inventors: Youcef Rustum, Arup Bhattacharya, Karoly Toth, Harry Slocum, Rami Azrak, Sreenivasulu Chintala, Mukund Seshadri, Richard Mazurchuk
  • Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
    Publication number: 20070053840
    Abstract: Novel tetrapyrollic water soluble photosensitizing and imaging compounds and the methods of treating and imaging hyperproliferative tissue, e.g. tumors and hypervacularized tissue such as found in macular degeneration. Broadly, the compounds are tetrapyrollic photosensitizer compounds where the tetrapyrollic compound is a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide having 3 to 6 —CH2CONHphenylCH2CH(N(CH2COOH)2))(CH2N(CH2COOH)(CH2CH2N(CH2COOH)2)) groups or esters thereof or complexes thereof with gadolinium(III).
    Type: Application
    Filed: June 30, 2006
    Publication date: March 8, 2007
    Applicant: Health Research, Inc.
    Inventors: Ravindra Pandey, Lalit Goswami, Joseph Spernyak, Peter Kanter, Richard Mazurchuk
  • Hybrid inorganic nanoparticles, methods of using and methods of making
    Publication number: 20060222587
    Abstract: The invention provides hybrid inorganic nanoparticles, methods of making the hybrid inorganic nanoparticles and methods of using the hybrid inorganic nanoparticles.
    Type: Application
    Filed: March 29, 2006
    Publication date: October 5, 2006
    Inventors: Paras Prasad, Richard Mazurchuk, Dhruba Bharali, Dinesh Sukumaran, Earl Bergey, Joseph Spernyak, Mukund Seshadri