Patents by Inventor Richard Mazzarella

Richard Mazzarella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • P-cadherin antibodies
    Publication number: 20060240001
    Abstract: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
    Type: Application
    Filed: April 25, 2006
    Publication date: October 26, 2006
    Inventors: Christopher Bauer, Maureen Bourner, Melanie Boyle, Gerald Casperson, David Griggs, Richard Head, William Joy, Richard Mazzarella, Ralph Minter, Mark Moffat, Barrett Thiele, Todd Vanarsdale
  • Differentially expressed genes involved in cancer, the polypeptides encoded thereby, and methods of using the same
    Publication number: 20050037439
    Abstract: The invention relates nucleic acids and their encoded polypeptides, whose expression is modulated in cancer or tumor cells. The invention further relates to methods useful for treating or modulating cancer or tumors in mammals in need of such biological effect. This includes the diagnosis and treatment of oncological disorders. Additionally, the present invention further relates to the use of antibodies against the polypeptides of the present invention as diagnostic probes or as therapeutic agents as well as the use of polynucleotide sequences encoding the polypeptides of the present invention as diagnostic probes or therapeutic agents for the treatment of a broad range of pathological states.
    Type: Application
    Filed: October 29, 2003
    Publication date: February 17, 2005
    Inventors: Maureen Bourner, Paul Hippenmeyer, Richard Head, Richard Mazzarella, Nicholas Staten, Barbara Klein
  • ESM-1 gene differentially expressed in angiogenesis, antagonists thereof, and methods of using the same
    Publication number: 20040167067
    Abstract: The invention relates a nucleic acid and its encoded polypeptide ESM-1, whose expression is modulated in angiogenesis and oncogenesis. The invention also relates to antibodies having specificity for said polypeptide. The present invention also relates to antisense molecules. The invention further relates to methods useful for treating or modulating angiogenesis in mammals in need of such biological effect.
    Type: Application
    Filed: July 1, 2003
    Publication date: August 26, 2004
    Inventors: David Griggs, Richard Head, Richard Mazzarella, Edward Weinstein
  • Differentially expressed genes involved in angiogenesis, the proteins encoded thereby, and methods of using the same
    Publication number: 20030232367
    Abstract: The invention relates generally to the identification of nucleic acids and their encoded polypeptides, particularly VCC1, whose expression is modulated in angiogenesis. These nucleic acids and proteins have not previously been identified as having a biological role in angiogenesis. The invention further relates to compounds that modulate VCC1 expression and/or activity. Methods of using these compounds for modulation of VCC-1 expression and for treatment of diseases associated with expression of VCC-1 are provided. Also included are methods of diagnosis of VCC1 associated angiogenic disorders.
    Type: Application
    Filed: April 11, 2003
    Publication date: December 18, 2003
    Inventors: Edward J. Weinstein, Richard Head, Richard Mazzarella, David Griggs