Abstract: The present invention refers to immunosuppression-reverting oligonucleotides comprising 12 to 18 nucleotides, wherein at least one of the nucleotides is modified, and the oligonucleotide hybridizes with an hybridizing active region of the nucleic acid sequence of an ectoenzyme (CD73) of SEQ ID NO.1 (human) and/or SEQ ID NO.2 (human). The invention is further directed to a pharmaceutical composition comprising such oligonucleotide. The oligonucleotide and the pharmaceutical composition are used in a method of preventing and/or treating a disorder, where a CD73 imbalance is involved.

Abstract: The present invention refers to oligonucleotides comprising 10 to 25 nucleotides, wherein at least one of the nucleotides is modified, and the oligonucleotide hybridizes with mRNA of angiotensin-converting enzyme 2 (ACE2) of SEQ ID NO.1 and/or with pre-mRNA of ACE2 of SEQ ID NO.2 resulting in a reduction of the level of ACE2, ACE2 mRNA, ACE2 pre-mRNA or a combination thereof of 30 to 99% compared to an untreated control. The invention is further directed to a pharmaceutical composition comprising such oligonucleotide. The oligonucleotide and the pharmaceutical composition are used in a method of preventing and/or treating a viral disease.

Abstract: Disclosed herein is an instrument that enables the in situ formation of architected planar biomaterials and tissues by translating a printer head along a deposition surface such as a patient having burn injuries. In handheld embodiments of the instrument, cell-laden biopolymer solutions are perfused through a moving microfabricated printer head and deposited onto a stationary planar surface or a wound. The printer head may be translated via a drive mechanism. A soft deformable roller mitigates further damage to the injured area of skin as it rolls over it and a gimbal mechanism to which the printer head is attached is in contact with the injured tissue but is configured so that the printer head while in contact with tissue, does not exert undue pressure on the would area.

Abstract: A data acquisition and control system includes a controller. The controller includes a CPU and memory, a network switch, a synchronization switch and a power distribution network. The network switch is configurable by the CPU and couples the CPU with an external network, a plurality of directly connected data acquisition modules, and a plurality of networked data acquisition modules. The synchronization switch is configurable by the CPU couples the CPU with the plurality of directly connected data acquisition modules. The power distribution network supplies power to the plurality of directly connected data acquisition modules, and the plurality of networked data acquisition modules. The data acquisition modules comprise a CPU coupled to a local storage with the local storage storing an application program. The data acquisition modules also have a network interface, a programmable logic block, and a sensor interface comprising an excitation output and a data acquisition input.

Abstract: Leak rate testing is an engineering challenge where on the one hand, engineers must meet strict leak rate standards on a wide range of products and systems from semiconductor packages through medical product packaging to chemical storage vessels and liquid/gas handling systems. On the other hand, they have to make the leak testing process low cost and independent of operator whilst in many applications making the process automated and fast as this step may otherwise become a manufacturing bottleneck. Accordingly embodiments of the invention address manufacturing requirements by providing for high accuracy flow based leak testing of large volumes, providing adaptive techniques for use during testing, providing equivalent circuit modeling techniques allowing optimization and parameter extraction to be simulated prior to manufacturing commitment, and providing for the automatic tuning of setup parameters.

Abstract: In one embodiment, a combine harvester comprising a chassis; and a grain storage bin coupled to the chassis, the bin comprising a single-walled, plastic storage container for the storage of crop material processed by the combine harvester.

Abstract: In one embodiment, a combine harvester comprising a chassis; and a double-walled, plastic grain storage bin coupled to the chassis, the bin configured to store crop material processed by the combine harvester.

Abstract: In one embodiment, a combine harvester comprising a chassis; and a double-walled, plastic grain storage bin coupled to the chassis, the bin comprising an integrated support structure disposed on an interior surface of the bin that contacts crop material processed by the combine harvester.

Abstract: Leak rate testing is an engineering challenge where on the one hand, engineers must meet strict leak rate standards on a wide range of products and systems from semiconductor packages through medical product packaging to chemical storage vessels and liquid/gas handling systems. On the other hand, they have to make the leak testing process low cost and independent of operator whilst in many applications making the process automated and fast as this step may otherwise become a manufacturing bottleneck. Accordingly embodiments of the invention address manufacturing requirements by providing for high accuracy flow based leak testing of large volumes, providing adaptive techniques for use during testing, providing equivalent circuit modeling techniques allowing optimization and parameter extraction to be simulated prior to manufacturing commitment, and providing for the automatic tuning of setup parameters.

Abstract: Leak rate testing is an engineering challenge where on the one hand, engineers must meet strict leak rate standards on a wide range of products and systems from semiconductor packages through medical product packaging to chemical storage vessels and liquid/gas handling systems. On the other hand, they have to make the leak testing process low cost and independent of operator whilst in many applications making the process automated and fast as this step may otherwise become a manufacturing bottleneck. Accordingly embodiments of the invention address manufacturing requirements by providing for high accuracy flow based leak testing of large volumes, providing adaptive techniques for use during testing, providing equivalent circuit modeling techniques allowing optimization and parameter extraction to be simulated prior to manufacturing commitment, and providing for the automatic tuning of setup parameters.

Abstract: The writing pole is formed of a magnetic material and includes a pole tip having an air-bearing surface and a throat portion extending away from the pole tip and away from the air-bearing surface. At least two surfaces of the throat portion are non-perpendicular to the air-bearing surface.

Abstract: A method, system and computer program for executing a hot migration operation are provided. A hot migration operation is executed from a first version of a service using a first data model, to a second version of the service using a second data model that is modified with respect to said first data model. A service comprises a client application, a data manager and a data repository. The migrate operation is effected on a server facility that accommodates multiple processes to be running in parallel. Second version client applications, a second version data manager operating according to the second data model, and a second version data repository arranged according to the second data model and cooperating with the second version data manager are installed. The first and the second version data managers are provided each with a migration plug-in.

Abstract: A single-use cosmetic applicator 1 has an applicator body 2 with a front surface 3 and a rear surface 4. The cosmetic applicator 1 has a sealed substantially impermeable membrane containing a pre-determined quantity of a cosmetic product 5 attached to an inner surface of a substantially impermeable cover, so that the membrane lies between the cover 7 and the applicator body 2.

Abstract: Methods of fabricating spin valve sensors in accordance with the invention include forming a pinning layer from an antiferromagnetic material and forming a synthetic antiferromagnet adjacent the pinning layer. A free ferromagnetic layer is formed, and exchange tabs are formed adjacent outer portions of the free ferromagnetic layer for biasing the free layer. The exchange tabs are formed from the same antiferromagnetic material as the first pinning layer. Then, the magnetic moments of the synthetic antiferromagnet are set, and the magnetic moment of the free ferromagnetic layer is biased, during a single anneal in the presence of a single magnetic field.

Abstract: A single-use cosmetic applicator 1 has an applicator body 2 with a front surface 3 and a rear surface 4. The cosmetic applicator 1 contains a pre-determined quantity of a cosmetic product 5 on only a portion of its front surface 3.

Abstract: A single-use cosmetic applicator 1 has an applicator body 2 with a front surface 3 and a rear surface 4. The cosmetic applicator 1 has a sealed substantially impermeable membrane containing a pre-determined quantity of a cosmetic product 5 attached to an inner surface of a substantially impermeable cover, so that the membrane lies between the cover 7 and the applicator body 2.

Abstract: The invention concerns the use of a polyamine derivative or a polyamine for inhibiting the active site of glycosidase enzymes intervening in the transformation of polysaccharides into sugars, in particular into glucose, in a living organism.