Abstract: This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.

Abstract: A blood processing device includes a pump system, a valve system, a centrifuge, and a controller configured and/or programmed to control the operation of the pump system, the valve system, and the centrifuge to execute a blood separation procedure. The blood separation procedure executed by the controller includes pumping blood into the centrifuge, separating the blood in the centrifuge into red blood cells and plasma, and collecting portions of the separated red blood cells and plasma. Subsequently, a portion of the collected red blood cells is pumped back into the centrifuge to collect an additional amount of the separated plasma. A buffy coat or white blood cell layer may be formed between the separated red blood cells and plasma in the centrifuge. If so, a portion of the collected plasma may be pumped back into the centrifuge to harvest the buffy coat or white blood cell layer.

Abstract: Disclosed are various embodiments of permanent active sensors in a tire achieved by partially embedding a sensor component in a green tire and adding a removable power source after the tire is cured. The printed circuit board can be encapsulated in the rubber of the tire with a power source housing connected to the electronics through the rubber. In another aspect, the printed circuit board can be directly connected to the power source housing. The sensor interlocks with the rubber of the tire. Various structural features of the sensor, such as a flange or channels for the rubber, can be used to secure the sensor in the rubber of the tire.

Abstract: A blood processing device includes a pump system, a valve system, a centrifuge, and a controller configured and/or programmed to control the operation of the pump system, the valve system, and the centrifuge to execute a blood separation procedure. The blood separation procedure executed by the controller includes pumping blood into the centrifuge at an inflow rate, separating the blood in the centrifuge into red blood cells and plasma, with an interface between the red blood cells and plasma located at an interface position within the centrifuge, and pumping at least a portion of the red blood cells and at least a portion of the plasma out of the centrifuge. The controller is configured and/or programmed to employ an inflow rate and/or an interface position that is based at least in part on the temperature of the blood.

Abstract: A Wireless Interface Device and System (WIDS) is used as a bridge device for transmitting, translating, transporting and/or transforming a first emergency aid seeking signal to a second emergency aid seeking signal recognizable by a smart voice commendable device (e.g., AMAZON® ECHO®). The first emergency aid seeking signal can be generated from a Personal Emergency Response Systems (PERS), a fall sensor (e.g., a senior fall sensor), home security monitoring device, or any other emergency aid requesting devices.

Abstract: A microfluidic magnetic selector comprises a microfluidic channel comprising at least one bifurcation, forming a selection portion of the selector and splitting the microfluidic channel into a main channel and at least one selection channel; at least one magnetic flux concentrator for concentrating a magnetic flux at the level of the bifurcation, and means for generating a magnetic field within the magnetic flux concentrator, and a controller for controlling magnetic pulses through the magnetic flux concentrator.

Abstract: A microfluidic magnetic selector comprises a microfluidic channel comprising at least one bifurcation, forming a selection portion of the selector and splitting the microfluidic channel into a main channel and at least one selection channel; at least one magnetic flux concentrator for concentrating a magnetic flux at the level of the bifurcation, and means for generating a magnetic field within the magnetic flux concentrator, and a controller for controlling magnetic pulses through the magnetic flux concentrator.