Abstract: An ex vivo method for the diagnostic and/or prognostic assessment of the acute-on-chronic liver failure (ACLF) syndrome in a patient with a liver disorder, includes measuring a panel of metabolites related with acylcarnitines-sialic acid-acetylated amino acids and amino acid derivatives and/or sugar alcohols, catecholamines and pyrimidine derivatives in a biological sample of the patient, and comparing the level of the metabolites in the sample with the level of the metabolites in healthy patients. An increase of at least 1.2 times of the level of the metabolites is indicative of ACLF syndrome.

Abstract: A tire manufacturing method and system is provided for controlling a product profile having one or more elastomeric layers that are produced by continuously extruding an elongated element (200) of an elastomeric material and depositing the elongated element (200) upon a forming surface (100a) of a circumferentially rotating drum (100).

Abstract: The present invention relates to methods for predicting the survival time of patients with decompensated alcoholic cirrhosis. In particular, the present invention relates to a method for predicting the survival time of a patient with decompensated alcoholic cirrhosis comprising i) determining the expression level of OAS2 or MX2 in a sample of peripheral blood mononuclear cells obtained from the patient, ii) comparing the level determined at step i) with a predetermined reference value and iii) and concluding that the patient will have a short survival time when the level determined at step i) is higher than its predetermined reference value or concluding that the patient will have a long survival time when the level determined at step i) is lower than the predetermined reference value.

Abstract: A tire manufacturing method and system is provided for controlling a product profile having one or more elastomeric layers that are produced by continuously extruding an elongated element (200) of an elastomeric material and depositing the elongated element (200) upon a forming surface (100a) of a circumferentially rotating drum (100).

Abstract: The present invention relates to methods for predicting the survival time of patients with decompensated alcoholic cirrhosis. In particular, the present invention relates to a method for predicting the survival time of a patient with decompensated alcoholic cirrhosis comprising i) determining the expression level of OAS2 or MX2 in a sample of peripheral blood mononuclear cells obtained from the patient, ii) comparing the level determined at step i) with a predetermined reference value and iii) and concluding that the patient will have a short survival time when the level determined at step i) is higher than its predetermined reference value or concluding that the patient will have a long survival time when the level determined at step i) is lower than the predetermined reference value.

Abstract: The present invention relates to an improved method for the treatment of hypovolaemia or hypotension associated with therapeutic paracentesis, which method is characterised by the use of a peptide according to general formulae (I) or a salt thereof, wherin Asn, Cys, Gln, Gly, Phe and Pro represent the amino acid residues asparigine, cysteine, glutamine, glycine, phenylalanine and proline respectively; Phe(X) represents a phenylalanine residue optionally substituted at the 4-position of the aromatic ring by a group selected from methyl, ethyl, hydroxy and methoxy; Y represents a group —(CH2)a—NH-Q, where a is 2–5 and Q is H or C(?NH)NH2; and R represents a chain of between two and for ?alpha-amino acid residues, at least one of which is glycine, as the active agent. The invention also provides uses of the peptide and pharmaceutical compositions.

Abstract: The present invention relates to an improved method for the treatment of hypovolaemia or hypotension associated with therapeutic paracentesis, which method is characterised by the use of a peptide according to general formulae (I) or a salt thereof, wherin Asn, Cys, Gln, Gly, Phe and Pro represent the amino acid residues asparigine, cysteine, glutamine, glycine, phenylalanine and proline respectively; Phe(X) represents a phenylalanine residue optionally substituted at the 4-position of the aromatic ring by a group selected from methyl, ethyl, hydroxy and methoxy; Y represents a group —(CH2)—NH-Q, where a is 2-5 and Q is H or C(═NH)NH2; and R represents a chain of between two and for &agr;alpha-amino acid residues, at least one of which is glycine, as the active agent. The invention also provides uses of the peptide and pharmaceutical compositions.

Abstract: A separate valve, rotatable with a pump control valve in a multiple plunger type fuel injection pump used to sequentially supply fuel to a number of fuel injection nozzles, is actuated by a solenoid to control fuel spill from each plunger whereby to control quantity and timing of injection.

Abstract: An inwardly opening valve type, fuel injection nozzle is provided with a part or parts thereof electrically insulated relative to its housing and the movable injector valve therein so that when the injector valve is closed an electrical circuit can be completed through the injector valve and housing and when the injector valve is moved to an open position, the continuity of this circuit is broken, By connecting an electrical continuity tester to this circuit, the opening and closing of the injector valve can be detected and can be used to set the timing of a diesel engine.