Abstract: Embodiments presented herein describe a method for processing streams of data of one or more networked computer systems. According to one embodiment of the present disclosure, an ordered stream of normalized vectors corresponding to information security data obtained from one or more sensors monitoring a computer network is received. A neuro-linguistic model of the information security data is generated by clustering the ordered stream of vectors and assigning a letter to each cluster, outputting an ordered sequence of letters based on a mapping of the ordered stream of normalized vectors to the clusters, building a dictionary of words from of the ordered output of letters, outputting an ordered stream of words based on the ordered output of letters, and generating a plurality of phrases based on the ordered output of words.

Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

Abstract: A body side member of an ostomy appliance comprising a cover layer forming a distal surface having one or more openings to allow egression of a releasable material to be shifted between a first position underneath the cover layer to a second position on top of the cover layer in use of the body side member around a stoma of a user.

Abstract: In various embodiments method are provided for generating expression cassettes and gene therapy vectors comprising those cassettes that recapitulate the spatiotemporal pattern of expression of the endogenous gene. In certain embodiments the methods comprise (i) selecting a target gene; (ii) identifying putative regulatory elements associated with the target gene; (iii) determining if the regulatory element is a key regulatory element and (iv) providing a list of the key regulatory elements identified in step (iii).

Abstract: An ostomy device includes a nonwoven element having a water-soluble component and a releasable material. When the ostomy device is applied to a user and stomal output contacts the distal surface of the nonwoven element, the water-soluble component dissolves and releases the releasable material from the nonwoven element to neutralize at least one of enzyme activity and pH of the stomal output.

Abstract: The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.

Abstract: An anal probe is provided. The probe has a retention part and a stem, where the retention part flares outward from its attachment to the stem and towards the insertion end. The retention part may be made of a soft resilient material.

Abstract: An accessory separate from and attachable to an adhesive body side member of an ostomy appliance is disclosed. The accessory includes a proximal surface that is attachable to a distal side of the adhesive body side member and a distal surface opposite from and connected to the proximal surface. The accessory has a pocket formed between the proximal surface and the distal surface of the accessory, with an opening formed to communicate with the pocket, and manipulable material disposed in the pocket. The manipulable material is adapted to be displaced out of the pocket through the opening and is adapted to absorb stoma moisture to prevent the stoma moisture from reaching an adhesive of the adhesive body side member to effectively increase a wear time of the adhesive body side member.

Abstract: Embodiments presented herein describe a method for processing streams of data of one or more networked computer systems. According to one embodiment of the present disclosure, an ordered stream of normalized vectors corresponding to information security data obtained from one or more sensors monitoring a computer network is received. A neuro-linguistic model of the information security data is generated by clustering the ordered stream of vectors and assigning a letter to each cluster, outputting an ordered sequence of letters based on a mapping of the ordered stream of normalized vectors to the clusters, building a dictionary of words from of the ordered output of letters, outputting an ordered stream of words based on the ordered output of letters, and generating a plurality of phrases based on the ordered output of words.

Abstract: An anal irrigation system with a box for a reservoir is provided. The reservoir may be for one-time use and disposed of after use. The box is provided with means for pressing so that the box can be used to displace liquid from a reservoir in an easy and convenient way. Also provided is a box with means for pressing so as to displace liquid from a reservoir. Also provided is an anal irrigation system without reservoir and where the box is provided with an inflatable lung, which is inflated for displacing the liquid from the box.

Abstract: A urinary catheter assembly includes an intermittent urinary catheter disposed in a cavity formed by a handle, and a connector, and a sleeve attached between the handle and the connector. The connector has a drain. The drain is formed by an outer wall of the connector separated from an inner wall of the connector by a channel.

Abstract: The present disclosure provides a method of producing an aluminum salt, comprising reacting activated aluminum metal (Al(0)) with an anion donor. Also provided are aluminum salts prepared by the disclosed methods.

Abstract: We disclose a method of providing a user or a healthcare worker with an ostomy device that is shape-adjustable to conform to skin around a stoma associated with a bulge or a hernia. The ostomy device is configured to invert from a storage configuration to a use configuration by inverting a substantially convex shape of a proximal side of a base plate to a substantially concave shape and stabilizing the base plate in the use configuration by contacting the inner radial periphery of the reinforcing structure with a distal surface of the base plate.

Abstract: A perforated filtration insert includes a head unit and a body portion having perforated side walls. The body portion is closed at one end by a cap such that fluid entering the body exits through the perforations in the side walls of the insert.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: An ostomy device includes a nonwoven element having a water-soluble component and a releasable material. When the ostomy device is applied to a user and stomal output contacts the distal surface of the nonwoven element, the water-soluble component dissolves and releases the releasable material from the nonwoven element to neutralize at least one of enzyme activity and pH of the stomal output.

Abstract: The present invention relates to authorising access to data (132) associated with a user. Aspects of the invention provide a computer-implemented method, computer software, a system and a computing device. The method comprises receiving, at an application server (120) from a first device (110), a request to access the data (132) associated with the user. The data (132) is hosted at a data server (130) external to the application server (120). The application server (120) provides an authorisation request (510) to an authorisation server (140); and the authorisation request is transmitted from the authorisation server (140) to an authorisation application (310) executed on a second device (150) associated with the user.

Abstract: Disclosed is a complementary-material element (22) attachable to a base plate (24) of an ostomy appliance (20) and including a first entity (30) and a second entity (32). The entities comprise different material compositions. The material composition of the second entity comprises a neutralizer which is released from the complementary-material element in response to moisture, thereby neutralizing the damaging effects of stomal output.

Abstract: An accessory separate from and attachable to an adhesive body side member of an ostomy appliance is disclosed. The accessory includes a proximal surface that is attachable to a distal side of the adhesive body side member and a distal surface opposite from and connected to the proximal surface. The accessory has a pocket formed between the proximal surface and the distal surface of the accessory, with an opening formed to communicate with the pocket, and manipulable material disposed in the pocket. The manipulable material is adapted to be displaced out of the pocket through the opening and is adapted to absorb stoma moisture to prevent the stoma moisture from reaching an adhesive of the adhesive body side member to effectively increase a wear time of the adhesive body side member.

Abstract: A body side member of an ostomy appliance comprising a nonwoven element comprising a releasable material. Contact of the nonwoven element with liquid allow release of the releasable material from the nonwoven element. The releasable material may act to neutralise enzyme activity or pH of stomal exudate.