Patents by Inventor Richard Mueller

Richard Mueller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
    Publication number: 20060020009
    Abstract: Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1-R6, R7, R7?, R8, R30-R34, X?, Y, Y?, t, x, and n are as defined herein, are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: July 18, 2005
    Publication date: January 26, 2006
    Applicant: G.D. Searle & Co.
    Inventors: Michael Vazquez, Richard Mueller, John Talley, Daniel Getman, Gary DeCrescenzo, Eric Sun
  • Method for preparing intermediates useful in synthesis of retroviral protease inhibitors
    Patent number: 6974876
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: December 13, 2005
    Assignee: G.D. Searle & Co.
    Inventors: John S Ng, Claire A. Przybyla, Richard A Mueller, Michael L Vazquez, Daniel P Getman
  • Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
    Publication number: 20050267153
    Abstract: Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.
    Type: Application
    Filed: August 3, 2004
    Publication date: December 1, 2005
    Inventors: Richard Mueller, Martin Bryant, Richard Partis, Gary Jacob, Timothy Block, Raymond Dwek
  • Alpha-and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Publication number: 20050267171
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: April 21, 2005
    Publication date: December 1, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Michael Vazquez, Richard Mueller, John Talley, Daniel Getman, Gary DeCrescenzo, John Freskos, Deborah Bertenshaw, Robert Heintz
  • Alpha-and beta-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
    Publication number: 20050267214
    Abstract: Certain Alpha- and Beta-amino acid hydroxyethylamino sulfamic acid derivatives represented by the following formula are useful as retroviral protease inhibitors:
    Type: Application
    Filed: June 28, 2005
    Publication date: December 1, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Michael Vazquez, Richard Mueller, John Talley, Daniel Getman, Gary DeCrescenzo, Eric Sun
  • Real-time multimedia fishing tournament weigh-in data distribution system
    Publication number: 20050240420
    Abstract: A method and apparatus for providing a real-time multimedia fishing tournament weigh-in data distribution system over the Internet. The system includes a data detection module for detecting components of real-time multimedia fishing tournament data. A client module residing at a tournament site obtains and distributes multimedia fishing tournament data received from the data detection module to a server module via the Internet. The server module in turn processes and streams the processed real-time multimedia fishing tournament data to one or more users coupled to the Internet.
    Type: Application
    Filed: April 22, 2004
    Publication date: October 27, 2005
    Inventors: Scott Iverson, Jacob Sevlie, Richard Mueller, Douglas Andersen, Kirk Hemmen, William Petrowiak, David Mahler, Douglas Chessor, Charlie Hoover
  • Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
    Patent number: 6951886
    Abstract: Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein the substituents are as defined in the specification, are effective as retroviral protease inhibitors and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: October 4, 2005
    Assignee: G. D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, Eric T. Sun
  • Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
    Publication number: 20050171366
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Application
    Filed: October 13, 2004
    Publication date: August 4, 2005
    Applicant: G.D. Searle & Co.
    Inventors: John Ng, Claire Przybyla, Richard Mueller, Michael Vazquez, Daniel Getman
  • Apparatus and method for delivering therapeutic and diagnostic agents
    Publication number: 20050171474
    Abstract: A drug-delivery tool and method for delivering a diagnostic or therapeutic agent to a target site within a selected body tissue, such as the myocardium of the heart, is disclosed. The drug-delivery tool generally includes an accessing device having a tissue-penetrating implement in its distal-end region, and elements for delivering a selected agent into a cavity formed by the implement. Methods of use are also described.
    Type: Application
    Filed: March 25, 2005
    Publication date: August 4, 2005
    Inventor: Richard Mueller
  • Ozone injection method and system
    Publication number: 20050167369
    Abstract: A target biokill of species for water to be discharged from a ballast tank of a sea faring vessel is determined. A diverted portion of sea water is regulated prior to charging the water into the ballast tank. Regulation of the diverted portion of water and a rate of injection of the ozone into the portion are adjusted to attain the target biokill. Then ozone at the determined rate into the regulated diverted portion to attain the target biokill when the portion is recombined into the water for charging to the ballast tank.
    Type: Application
    Filed: January 24, 2005
    Publication date: August 4, 2005
    Inventors: Jack Robinson, Michael Jennings, Richard Mueller
  • ?- and ?-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6924286
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: August 4, 2003
    Date of Patent: August 2, 2005
    Assignee: G. D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Deborah E. Bertenshaw, Robert M. Heintz
  • Methods and apparatus for anchoring an occluding member
    Publication number: 20050148997
    Abstract: Pressure is measured on both sides of an occluding member for determining when pressure forces on the occluding member may cause migration of the occluding member. An alarm indicates when the pressure force on the balloon exceed a predetermined threshold. In another aspect of the invention, a pressure monitor determines when a rate of pressure increase with respect to the fluid volume in the balloon reaches a predetermined threshold when inflating the occluding member. A predetermined amount of fluid is then added to the balloon so that the balloon is not under inflated or over inflated.
    Type: Application
    Filed: February 14, 2005
    Publication date: July 7, 2005
    Inventors: Kirsten Valley, David Snow, Sylvia Fan, Richard Mueller
  • Cellular arrays and methods of detecting and using genetic disorder markers
    Patent number: 6905823
    Abstract: A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array, and performing a different biological analysis of each copy. The results of the different biological analyses are compared to determine if there are correlations between the results of the different biological analyses at each assigned location. In some embodiments, the specimens may be tissue specimens from different tumors, which are subjected to multiple parallel molecular (including genetic and immunological) analyses. The results of the parallel analyses are then used to detect common molecular characteristics of the genetic disorder type, which can subsequently be used in the diagnosis or treatment of the disease.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: June 14, 2005
    Assignee: Abbott Laboratories
    Inventors: Olli-P Kallioniemi, Uwe Richard Müller, Guido Sauter, Juha Kononen, Maarit Barlund
  • Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
    Publication number: 20050119310
    Abstract: Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.
    Type: Application
    Filed: February 13, 2001
    Publication date: June 2, 2005
    Inventors: Richard Mueller, Martin Bryant, Kimberly Bryant
  • Biopsy device having endoscope
    Publication number: 20050113716
    Abstract: A biopsy device having an endoscope comprises a biopsy instrument, suitable for collecting at least one tissue sample from a body lumen, such as a mammary duct, and a cutter introducer sized for receiving the biopsy instrument and introducing the biopsy instrument into a mammary duct to retrieve a tissue sample therefrom.
    Type: Application
    Filed: January 3, 2005
    Publication date: May 26, 2005
    Inventors: Richard Mueller, Paul Hsei, James Kermode
  • Catheter retainer
    Publication number: 20050113759
    Abstract: A catheter retainer includes a spacer and an anchor that coact to maintain a catheter in a predetermined position within a mammary duct during a ductal lavage procedure. The spacer and the anchor operate together to resist angular or axial displacement of the catheter. A catheter retainer kit is disclosed as well.
    Type: Application
    Filed: November 24, 2003
    Publication date: May 26, 2005
    Inventors: Richard Mueller, James Kermode, Douglas Murphy-Chutorian
  • Biopsy device with viewing assembly
    Publication number: 20050070818
    Abstract: A biopsy device suitable for collection of a tissue sample from a biopsy site in a body lumen is provided. The biopsy device comprises a combination of an introducer assembly, a cutter assembly, and an endoscope assembly that coact with one another. The introducer assembly includes a hollow sheath having a distal end portion defining an aperture suitable for receiving a tissue mass therein. The cutter assembly includes a cutter tube having a distal end portion with a cutting edge. The cutter tube is sized to fit axially within the introducer sheath. The endoscope assembly includes a bundle of optical fibers sized to fit axially within the cutter tube. In use, the fiber optic bundle of the endoscope is nested within the cutter tube, which in turn is nested within the introducer sheath to form a co-axial structure.
    Type: Application
    Filed: September 30, 2003
    Publication date: March 31, 2005
    Inventor: Richard Mueller
  • Lavage assist device
    Publication number: 20050070817
    Abstract: A harness and method for reducing systemic losses in ductal lavage procedures is provided comprising a base member having a first surface and a second surface and a through aperture sized to receive a human breast therethrough. The through aperture includes a breast stabilizer that is suitable for compressing at least a portion of the breast near or proximate the chest. The compression of the breast radially is sufficient to act as a moderate tourniquet on the breast to reduce systemic losses.
    Type: Application
    Filed: September 30, 2003
    Publication date: March 31, 2005
    Inventor: Richard Mueller
  • Ballast water ozone injection method and system
    Patent number: 6869540
    Abstract: A method to treat ballast water comprises injecting ozone into water loading into a sea faring vessel prior to charging the water into a ballast tank; and charging the ozone injected water into the ballast tank. A system for treating ballast water comprises a sea faring vessel including at least one ballast tank; an ozone generator that generates ozone, a ballast water conduit that uptakes water through a loading port of a sea faring vessel and conducts the water to load the ballast tank; and an ozone feed line that injects ozone from the generator into water in the conduit at an injection point located upstream to an intersection of the conduit with the ballast tank.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: March 22, 2005
    Assignee: Nutech 03
    Inventors: Jack H. Robinson, Michael D. Jennings, Richard A. Mueller
  • ?- and ?-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6846954
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: January 25, 2005
    Assignee: G. D. Searle & Co.
    Inventors: Michael L Vazquez, Richard A. Mueller, John J. Talley, Daniel P Getman, Gary A. DeCrescenzo, John N. Freskos, Robert M. Heintz, Deborah E. Bertenshaw