Abstract: A computer-based method is provided for deriving a genome of an individual. The method comprises the steps of accessing a selector for an individual and a reference template for a group genome, the selector comprising a locus value and a base value; and processing the selector and the reference template to derive a sequence representative of the genome of the individual. The reference template preferably comprises data components representing a probability of occurrence of a base value. The probability of occurrence is based on base value occurrences at corresponding locus values in the group genome. The method of the present invention further comprises computing a base value from the data component in the reference template, for base values not in the selector.

Abstract: A computer-based method is provided for deriving a reference sequence for expressing a group genome. The method includes determining a probability of occurrence for a base value in the reference sequence based on base value occurrences in the group genome. The determined probability of occurrence is then inserted in the reference sequence. The probability of occurrence is preferably determined for a plurality of base values.