Patents by Inventor Richard N. Ellson

Richard N. Ellson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10112212
    Abstract: Devices and methods are provided for ejecting a droplet from a reservoir using focused acoustic radiation having a plurality of nonsimultaneous and discrete frequency ranges. Such frequency ranges may be used to control droplet volume and/or velocity. Optionally, satellite fluid ejection from the reservoir is suppressed.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: October 30, 2018
    Assignee: Labcyte Inc.
    Inventors: Richard G. Stearns, Mitchell W. Mutz, Richard N. Ellson
  • Publication number: 20180304251
    Abstract: Sample container for holding and transferring a liquid sample and method thereof. The sample container includes an inlet configured to allow a liquid sample to enter a sample container, and an outlet configured to allow one or more droplets of the liquid sample to exit the sample container by one or more acoustic ejections respectively. The inlet and the outlet are in different locations.
    Type: Application
    Filed: May 4, 2018
    Publication date: October 25, 2018
    Inventors: Richard N. Ellson, Joseph D. Olechno, Robert G. Kuimelis
  • Publication number: 20180282781
    Abstract: The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to the pathogen-containing fluid in the reservoir in a manner effective to eject a droplet of the fluid therefrom. Often, a pathogen-impermeable enclosure is used.
    Type: Application
    Filed: January 12, 2018
    Publication date: October 4, 2018
    Inventors: Mitchell W. Mutz, Richard N. Ellson
  • Publication number: 20180231442
    Abstract: A method and system are provided for detecting the concentration of an analyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic analyte detection device that provides a signal proportional in intensity to the quantity of ionized analyte detected. The improvement involves replacement of a necessary non-analyte component in the fluid sample with a substitute component that serves the same purpose as the original component but is either more volatile than the original component and/or the analyte or undergoes a reaction to provide lower molecular weight reaction products, and results in an increased intensity in signal and signal-to-noise ratio. Acoustic fluid ejection is a preferred method of generating nanoliter-sized droplets of fluid sample that are then volatilized, ionized, and analyzed.
    Type: Application
    Filed: April 9, 2018
    Publication date: August 16, 2018
    Inventors: Richard N. Ellson, Richard G. Stearns, Joseph D. Olechno, Ian Sinclair, Jonathan Wingfield
  • Patent number: 10016757
    Abstract: Sample container for holding and transferring a liquid sample and method thereof. The sample container includes an inlet configured to allow a liquid sample to enter a sample container, and an outlet configured to allow one or more droplets of the liquid sample to exit the sample container by one or more acoustic ejections respectively. The inlet and the outlet are in different locations.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: July 10, 2018
    Assignee: Labcyte Inc.
    Inventors: Richard N. Ellson, Joseph D. Olechno, Robert G. Kuimelis
  • Publication number: 20180169651
    Abstract: Provided herein is generally tubular container, preferably including a plurality of reservoirs defined therein. The container can be adapted for acoustic ejection of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs. Alternatively, the container can be adapted for extraction of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs using a non-acoustic liquid handling method.
    Type: Application
    Filed: October 13, 2017
    Publication date: June 21, 2018
    Inventor: Richard N. ELLSON
  • Patent number: 9939352
    Abstract: A method and system are provided for detecting the concentration of an analyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic analyte detection device that provides a signal proportional in intensity to the quantity of ionized analyte detected. The improvement involves replacement of a necessary non-analyte component in the fluid sample with a substitute component that serves the same purpose as the original component but is either more volatile than the original component and/or the analyte or undergoes a reaction to provide lower molecular weight reaction products, and results in an increased intensity in signal and signal-to-noise ratio. Acoustic fluid ejection is a preferred method of generating nanoliter-sized droplets of fluid sample that are then volatilized, ionized, and analyzed.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: April 10, 2018
    Assignee: LABCYTE, INC.
    Inventors: Richard N. Ellson, Richard G. Stearns, Joseph D. Olechno, Ian Sinclair, Jonathan Wingfield
  • Patent number: 9920352
    Abstract: Method and system for monitoring for a change in the amount and/or concentration of a pathogen in a pathogenic fluid. The method includes providing a pathogen-impermeable enclosure enclosing the pathogenic fluid, wherein the pathogenic fluid includes a pathogen and a carrier fluid. Additionally, the method includes acoustically monitoring for a change in the amount and/or concentration of the pathogen enclosed in the pathogen-impermeable enclosure.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: March 20, 2018
    Assignee: Labcyte Inc.
    Inventors: Mitchell W. Mutz, Richard N. Ellson
  • Publication number: 20180073029
    Abstract: A method is provided for achieving transfection of host cells using sonoporation. An acoustic radiation generator is positioned in acoustic coupling relationship with respect to a reservoir containing host cells to be transfected, exogenous material to be incorporated into the host cells, and a cell-compatible fluid medium. The acoustic radiation generator is activated to generate acoustic radiation and direct the acoustic radiation into the reservoir in a manner effective to enable transfection of the host cells with the exogenous material.
    Type: Application
    Filed: September 15, 2017
    Publication date: March 15, 2018
    Inventors: Jennifer M. Hardee, Richard N. Ellson, Richard G. Stearns, Babur Hadimioglu, Joseph D. Olechno, Marsha N. Blauwkamp
  • Patent number: 9861987
    Abstract: Provided herein is generally tubular container, preferably including a plurality of reservoirs defined therein. The container can be adapted for acoustic ejection of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs. Alternatively, the container can be adapted for extraction of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs using a non-acoustic liquid handling method.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: January 9, 2018
    Assignee: LABCYTE INC.
    Inventor: Richard N. Ellson
  • Patent number: 9610577
    Abstract: In an aspect of this invention, a closure for a well plate is provided which has a reservoir. The closure has openings through which acoustic ejection of fluid droplets can take place without removing the closure. The reservoirs in the closure may help to maintain acceptable levels of solvent in the wells of the well plate despite the evaporation which may occur during the course of ejection.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: April 4, 2017
    Assignee: LABCYTE INC.
    Inventor: Richard N. Ellson
  • Publication number: 20160214100
    Abstract: In an aspect of this invention, a closure for a well plate is provided which has a reservoir. The closure has openings through which acoustic ejection of fluid droplets can take place without removing the closure. The reservoirs in the closure may help to maintain acceptable levels of solvent in the wells of the well plate despite the evaporation which may occur during the course of ejection.
    Type: Application
    Filed: October 15, 2015
    Publication date: July 28, 2016
    Inventor: Richard N. ELLSON
  • Publication number: 20160109336
    Abstract: A method and system are provided for detecting the concentration of an analyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic analyte detection device that provides a signal proportional in intensity to the quantity of ionized analyte detected. The improvement involves replacement of a necessary non-analyte component in the fluid sample with a substitute component that serves the same purpose as the original component but is either more volatile than the original component and/or the analyte or undergoes a reaction to provide lower molecular weight reaction products, and results in an increased intensity in signal and signal-to-noise ratio. Acoustic fluid ejection is a preferred method of generating nanoliter-sized droplets of fluid sample that are then volatilized, ionized, and analyzed.
    Type: Application
    Filed: October 19, 2015
    Publication date: April 21, 2016
    Inventors: Richard N. Ellson, Richard G. Stearns, Joseph D. Olechno, Ian Sinclair, Jonathan Wingfield
  • Patent number: 9192932
    Abstract: In an aspect of this invention, a closure for a well plate is provided which has a reservoir. The closure has openings through which acoustic ejection of fluid droplets can take place without removing the closure. The reservoirs in the closure may help to maintain acceptable levels of solvent in the wells of the well plate despite the evaporation which may occur during the course of ejection.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: November 24, 2015
    Assignee: LABCYTE INC.
    Inventor: Richard N. Ellson
  • Publication number: 20150197372
    Abstract: A container may include a tubular sidewall defining interior and exterior surfaces of the container, and including first and second regions disposed relative to one another along a major axis of the tubular sidewall. The container further may include an identification mark embedded within the tubular sidewall at a plurality of sectors about the tubular sidewall within the first region. Each sector may have a width, and the identification mark is machine readable by a reader viewing any arbitrary one or more of the sectors. An exemplary method for preparing such a container is also provided.
    Type: Application
    Filed: January 12, 2015
    Publication date: July 16, 2015
    Inventors: Lars MAJLOF, Richard N. ELLSON
  • Publication number: 20150196904
    Abstract: Provided herein is generally tubular container, preferably including a plurality of reservoirs defined therein. The container can be adapted for acoustic ejection of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs. Alternatively, the container can be adapted for extraction of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs using a non-acoustic liquid handling method.
    Type: Application
    Filed: January 12, 2015
    Publication date: July 16, 2015
    Inventor: Richard N. ELLSON
  • Patent number: 8882226
    Abstract: To ejecting a droplet from a reservoir, the reservoir holding a fluid is moved with respect to an acoustic ejector. As the reservoir and ejector move closer together, the acoustic ejector sends one or more interrogation pulses towards the reservoir. Based on the interrogation pulses, the system determines when the movement of the reservoir has placed a free surface of the fluid in a position where a droplet can be ejected.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: November 11, 2014
    Assignee: Labcyte Inc.
    Inventor: Richard N. Ellson
  • Publication number: 20140092156
    Abstract: To ejecting a droplet from a reservoir, the reservoir holding a fluid is moved with respect to an acoustic ejector. As the reservoir and ejector move closer together, the acoustic ejector sends one or more interrogation pulses towards the reservoir. Based on the interrogation pulses, the system determines when the movement of the reservoir has placed a free surface of the fluid in a position where a droplet can be ejected.
    Type: Application
    Filed: September 3, 2013
    Publication date: April 3, 2014
    Applicant: Labcyte Inc.
    Inventor: Richard N. Ellson
  • Patent number: 8544976
    Abstract: To ejecting a droplet from a reservoir, the reservoir holding a fluid is moved with respect to an acoustic ejector. As the reservoir and ejector move closer together, the acoustic ejector sends one or more interrogation pulses towards the reservoir. Based on the interrogation pulses, the system determines when the movement of the reservoir has placed a free surface of the fluid in a position where a droplet can be ejected.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: October 1, 2013
    Assignee: Labcyte Inc.
    Inventor: Richard N. Ellson
  • Patent number: 8453507
    Abstract: Methods are provided for analyzing characteristics of fluids in the context of an acoustic ejection system. Such a system has a controller, an acoustic radiation generator, and a coupling medium coupling the radiation to a reservoir holding fluid. The methods can use acoustic radiation to both perturb a surface of the fluid in the reservoir and analyze the effect of the perturbation. The methods may use information about prior fluids. The methods of the invention can determine physical characteristics such as speed of sound and viscosity. The methods also include ways to determine a level of acoustic energy suitable to eject a droplet. Preferably the methods are executed automatically under control of programming of a controller of an acoustic ejection system.
    Type: Grant
    Filed: January 3, 2011
    Date of Patent: June 4, 2013
    Assignee: Labcyte Inc.
    Inventors: Richard N. Ellson, Mitchell W. Mutz