Abstract: Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome and hyperlipidemia.

Abstract: Machine learning analysis of mass spectrometry spectra from human sweat samples is used to determine characteristics of interest such as age, ethnicity, gender drug use and disease state directly from the m/z data. This avoids the difficult problem of performing a full chemical analysis of human sweat samples to determine the characteristics of interest.

Abstract: Aspects of the invention include methods for reducing a pathogen population. Methods according to certain embodiments, a source of the pathogen is contacted with a plurality of microdroplets having one or more reactive oxygen species. In certain embodiments, methods include producing the microdroplets by outputting an aqueous composition from an orifice of a flow channel to produce a plurality of microdroplets having one or more reactive oxygen species. In certain embodiments, methods include producing microdroplets through the condensation of water by contacting solid carbon dioxide with an aqueous composition such as by dropping the aqueous composition on the solid carbon dioxide or submerging the solid carbon dioxide in the aqueous composition to produce a plurality of microdroplets having one or more reactive oxygen species. Compositions of a plurality of microdroplets having one or more reactive oxygen species are also provided. Systems for practicing the subject methods are also described.

Abstract: Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome and hyperlipidemia.

Abstract: Improved two phase chemical reactions (liquid-liquid or liquid-gas) are provided by forming microdroplets of either or both liquid reagents and configuring the reaction as a collision between the microdroplet reagent and the other reagent. We have found that this approach can provide high reaction yields in short times (<1 s) without the use of a phase transfer catalyst.

Abstract: Methods and systems for determining a physiological parameter of a subject through interrogation of an eye of the subject with an optical signal are described. Interrogation is performed unobtrusively. The physiological parameter is determined from a signal sensed from the eye of a subject according to a schedule, under the control of a scheduling controller.

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to nanoparticles, compositions including nanoparticles, methods of making nanoparticles, and the like. In particular, embodiments of the present disclosure include nanoparticles and compositions for the sustained release (e.g., release at a predetermined rate to maintain a certain concentration for a certain period of time) of an agent, such as a small interfering RNA (siRNA) from the nanoparticle.

Abstract: Aspects of the invention include methods for modifying a surface of a non-porous hydrophobic polymer substrate having a backbone containing electrophilic linkages. In practicing methods according to certain embodiments, a liquid composition having a nucleophilic reagent and a catalyst is contacted with the surface of the non-porous hydrophobic polymer substrate and maintained in contact with the surface of the polymer substrate in a manner sufficient to convert at least a portion of the surface from hydrophobic to hydrophilic while retaining the mechanical and optical properties of the polymer substrate. Substrates, including containers, having one or more hydrophilic surfaces and kits suitable for practicing the subject methods are also described.

Abstract: Methods and systems for determining a physiological parameter of a subject through interrogation of an eye of the subject with an optical signal are described. Interrogation is performed unobtrusively. The physiological parameter is determined from a signal sensed from the eye of a subject according to a schedule, under the control of a scheduling controller.

Abstract: Methods and systems for determining a physiological parameter of a subject through interrogation of an eye of the subject with an optical signal are described. Interrogation is performed unobtrusively. The physiological parameter is determined from a signal sensed from the eye of a subject when the eye of the subject is properly aligned with regard to an interrogation signal source and/or response signal sensor.

Abstract: Machine learning analysis of mass spectrometry spectra from human sweat samples is used to determine characteristics of interest such as age, ethnicity, gender drug use and disease state directly from the m/z data. This avoids the difficult problem of performing a full chemical analysis of human sweat samples to determine the characteristics of interest.

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making nanostructures (e.g., nanoparticles, nanofibers), systems for making nanostructures, and the like.

Abstract: A filament for a light bulb includes a tube and a filament material within the tube, wherein the filament material is configured to be in a liquid state while the light bulb is in use.

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of delivering a compound, a composition, and the like.

Abstract: A filament for a light bulb includes a tube and a filament material within the tube, wherein the filament material is configured to be in a liquid state while the light bulb is in use.

Abstract: Embodiments of the present disclosure provide for particle-imprinted polymer films, methods of making particle-imprinted polymer films, methods for separating particles, devices or systems for separating particles, and the like.

Abstract: A filament for a light bulb includes a tube and a filament material within the tube, wherein the filament material is configured to be in a liquid state while the light bulb is in use.

Abstract: Methods and systems for determining a physiological parameter of a subject through interrogation of an eye of the subject with an optical signal are described. Interrogation is performed unobtrusively. The physiological parameter is determined from a signal sensed from the eye of a subject when the eye of the subject is properly aligned with regard to an interrogation signal source and/or response signal sensor.

Abstract: Methods and systems for determining a physiological parameter of a subject through interrogation of an eye of the subject with an optical signal are described. Interrogation is performed unobtrusively. The physiological parameter is determined from a signal sensed from the eye of a subject according to a schedule, under the control of a scheduling controller.

Abstract: Aspects of the invention include methods for modifying a surface of a non-porous hydrophobic polymer substrate having a backbone containing electrophilic linkages. In practicing methods according to certain embodiments, a liquid composition having a nucleophilic reagent and a catalyst is contacted with the surface of the non-porous hydrophobic polymer substrate and maintained in contact with the surface of the polymer substrate in a manner sufficient to convert at least a portion of the surface from hydrophobic to hydrophilic while retaining the mechanical and optical properties of the polymer substrate. Substrates, including containers, having one or more hydrophilic surfaces and kits suitable for practicing the subject methods are also described.