Patents by Inventor Richard Nicoletti

Richard Nicoletti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREDICTING TUMOR RESPONSE TO ANTI-ERBB3 ANTIBODIES
    Publication number: 20180195120
    Abstract: A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.
    Type: Application
    Filed: November 27, 2017
    Publication date: July 12, 2018
    Inventors: Sylvie Vincent, Kristan Meetze, Bin Feng, Steven Tyler, Steve Bottega, Richard Nicoletti, Donna McIntosh, Jeno Gyuris
  • Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
    Patent number: 9896730
    Abstract: The present invention provides diagnostic methods for assessing the EMT status of tumor cells, and for predicting the effectiveness of treatment of a cancer patient with an EGFR or IGF-1R kinase inhibitor, utilizing an EMT gene signature index score. The present invention further provides methods for treating patients with cancer that incorporate these methods.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: February 20, 2018
    Assignees: OSI Pharmaceuticals, LLC, AVEO PHARMACEUTICALS, INC.
    Inventors: Julie Kan, Stuart Thomson, Gretchen M. Argast, Matthew E. O'Connor, Murray Robinson, Bin Feng, Joerg Heyer, Maria I. Chiu, Richard Nicoletti
  • Predicting tumor response to anti-ERBB3 antibodies
    Patent number: 9828635
    Abstract: A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: November 28, 2017
    Assignee: AVEO Pharmaceuticals, Inc.
    Inventors: Sylvie Vincent, Kristan Meetze, Bin Feng, Steven Tyler, Steve Bottega, Richard Nicoletti, Donna McIntosh, Jeno Gyuris
  • PREDICTING TUMOR RESPONSE TO ANTI-ERBB3 ANTIBODIES
    Publication number: 20140242597
    Abstract: A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.
    Type: Application
    Filed: October 5, 2012
    Publication date: August 28, 2014
    Applicant: AVEO PHARMACEUTICALS, INC.
    Inventors: Sylvie Vincent, Kristan Meetze, Bin Feng, Steven Tyler, Steve Bottega, Richard Nicoletti, Donna McIntosh, Jeno Gyuris
  • USE OF EMT GENE SIGNATURES IN CANCER DRUG DISCOVERY, DIAGNOSTICS, AND TREATMENT
    Publication number: 20120302572
    Abstract: The present invention provides diagnostic methods for assessing the EMT status of tumor cells, and for predicting the effectiveness of treatment of a cancer patient with an EGFR or IGF-1R kinase inhibitor, utilizing an EMT gene signature index score. The present invention further provides methods for treating patients with cancer that incorporate these methods.
    Type: Application
    Filed: April 25, 2012
    Publication date: November 29, 2012
    Applicants: AVEO PHARMACEUTICALS, INC., OSI Pharmaceuticals, LLC
    Inventors: Julie Kan, Stuart Thomson, Gretchen M. Argast, Matthew E. O'Connor, Murray Robinson, Bin Feng, Joerg Heyer, Maria I. Chiu, Richard Nicoletti
  • AMENDMENT-FREE SLUDGE COMPOSTING
    Publication number: 20100184131
    Abstract: A composting system for promoting aerobic microbial activity in a composting bed. The system includes at least one composting bay for receiving composting material and an agitator for aerating and displacing composting material as it travels through the composting bay. Compost produced by the system is used in place of traditional woody amendment material for mixing with incoming material to be composted.
    Type: Application
    Filed: January 15, 2010
    Publication date: July 22, 2010
    Applicant: SIEMENS WATER TECHNOLOGIES CORP.
    Inventors: Richard Nicoletti, Lewis Naylor
  • Automated allele caller
    Patent number: 6274317
    Abstract: An auto allele caller executed in a computer system for identifying alleles from a trace is described. The auto allele caller applies a typical shape of an allele for a marker to the trace to identify potential allele calls that match to the typical shape of the allele at the marker and assigns a quality factor to the allele calls.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: August 14, 2001
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Martha J. Hiller, John W. Martin, Alexander N. Parker, Richard A. Nicoletti, Christopher R. Page