Abstract: Provided herein are anti-FN-EIIIB nanobodies, conjugates thereof, and methods of using the nanobodies and conjugates thereof.

Abstract: The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

Abstract: An introducer sheath assembly includes an expandable introducer sheath including an expandable braid defining an elongate tubular member moveable between a collapsed configuration for delivery and an expanded configuration for deployment, the expandable braid having a first length when in the collapsed configuration and a second, reduced, length when in the expanded configuration. The introducer sheath assembly includes a dilator adapted to releasably hold the expandable introducer sheath in its collapsed configuration for delivery until the dilator is actuated to release the expandable braid from the dilator, thereby permitting the expandable braid to expand to its expanded configuration.

Abstract: A lens system for eyeglasses, for selectively shading areas of glare and bright lights in the wearer's field of view, while maintaining an unshaded field of view everywhere else. The system is adjustable and includes a means for attaching to a wearer's eyeglasses.

Abstract: The present invention includes systems and methods for a continuous-wave (CW) radar system for detecting, geolocating, identifying, discriminating between, and mapping ferrous and non-ferrous metals in brackish and saltwater environments. The radar system (e.g., the CW radar system) generates multiple extremely low frequency (ELF) electromagnetic waves simultaneously and uses said waves to detect, locate, and classify objects of interest. These objects include all types of ferrous and non-ferrous metals, as well as changing material boundary layers (e.g., soil to water, sand to mud, rock to organic materials, water to air, etc.). The radar system (e.g., the CW radar system) is operable to detect objects of interest in near real time.

Abstract: The present invention includes systems and methods for a continuous-wave (CW) radar system for detecting, geolocating, identifying, discriminating between, and mapping ferrous and non-ferrous metals in brackish and saltwater environments. The radar system (e.g., the CW radar system) generates multiple extremely low frequency (ELF) electromagnetic waves simultaneously and uses said waves to detect, locate, and classify objects of interest. These objects include all types of ferrous and non-ferrous metals, as well as changing material boundary layers (e.g., soil to water, sand to mud, rock to organic materials, water to air, etc.). The radar system (e.g., the CW radar system) is operable to detect objects of interest in near real time.

Abstract: A method including detecting a presence of at least one analyte in a sample from a subject wherein the at least one analyte is selected from the group consisting of: mesothelin, Galectin-3-binding protein, Clusterin, Polymeric immunoglobulin receptor, Neutrophil gelatinase-associated lipocalin, Leucine-rich alpha-2-glycoprotein, Osteopontin, Alpha-amylase 1, WAP four-disulfide core domain protein 2, Mucin-16, GSTP1, PRDX5, TXN, PRDX6, and SOD1, and determining the subject has hydrosalpinx if the sample comprises an increased level of mesothelin, Galectin-3-binding protein, Clusterin, Polymeric immunoglobulin receptor, Neutrophil gelatinase-associated lipocalin, Leucine-rich alpha-2-glycoprotein, Osteopontin, Alpha-amylase 1, WAP four-disulfide core domain protein 2, and/or Mucin-16 relative to a control, and/or a decreased level of GSTP1, PRDX5, TXN, PRDX6, and/or SOD1, relative to the control, is provided herein.

Abstract: An embodiment of the invention includes a non-transitory computer-readable medium storing instructions that, when executed by a computer, cause the computer to carry out a method for scheduling at least one activity to achieve a time-varying energy balance of a power system. A mission plan for a mission is received. The mission plan includes at least one activity and at least one route. Each route of the at least one route includes at least one time and at least one location. A plurality of power load identifications is received for at least one time-varying power load for use in the mission plan. A plurality of energy storage device identifications is received for at least one energy storage device. Based on the plurality of power load identifications, a power requirement required to complete the mission plan is determined using the at least one power load. Based at least in part on the mission plan and the plurality of energy storage device identifications, an available power for the mission is determined.

Abstract: The present invention includes systems and methods for a continuous-wave (CW) radar system for detecting, geolocating, identifying, discriminating between, and mapping ferrous and non-ferrous metals in brackish and saltwater environments. The CW radar system generates multiple extremely low frequency (ELF) electromagnetic waves simultaneously and uses said waves to detect, locate, and classify objects of interest. These objects include all types of ferrous and non-ferrous metals, as well as changing material boundary layers (e.g., soil to water, sand to mud, rock to organic materials, water to air, etc.). The CW radar system is operable to detect objects of interest in near real time.

Abstract: A method of optimally placing spinal cord stimulator (SCS) leads includes acquiring components of somatosensory evoked potentials (SSEPs), compound action potentials and triggered EMG; analyzing the waveforms; and quantifying waveform features in a single display such that a surgeon can quickly and easily determine optimal placement (as it relates to laterality and level of placement on the spinal cord) of SCS leads in a patient under general anesthesia without additional expert help.

Abstract: The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

Abstract: The present invention includes systems and methods for a continuous-wave (CW) radar system for detecting, geolocating, identifying, discriminating between, and mapping ferrous and nonferrous metals in brackish and saltwater environments. The CW radar system generates multiple extremely low frequency (ELF) electromagnetic waves simultaneously and uses said waves to detect, locate, and classify objects of interest. These objects include all types of ferrous and nonferrous metals, as well as changing material boundary layers (e.g., soil to water, sand to mud, rock to organic materials, water to air, etc.). The CW radar system is operable to detect objects of interest in near real time.

Abstract: A bandsaw makes simultaneous, spaced-apart cuts in hard or soft materials with a single bandsaw blade. The invention is ideally suited to cutting spaced-apart parallel surfaces to form support blocks, however, different embodiment may be controlled or programmed to make parallel or non-parallel cuts at varying angles. The single bandsaw blade rides on circular wheels on both sides of a gap or passageway, such that a first portion of the blade crosses the passage along a first, upper path, and a second portion of the bandsaw blade crosses the passage along a second, lower path. A table moves the material through the passage, whereupon the material is simultaneously cut along two planes corresponding to the upper and lower paths of the bandsaw blade. A preferred embodiment includes a first set of upper and lower wheels on one side of the passage, and a second set of upper and lower wheels on an opposing side of the passage.

Abstract: Methods for developing disease-related nanobodies and related products and kits are provided. The disease-specific proteins are extracellular matrix (ECM) proteins, domains or epitopes that are associated with various aspects of disease and are not present, or are present in very low quantities, in non-diseased individuals. Highly effective nanobodies capable of specifically binding to these ECM protein epitopes useful in in vivo imaging assays, the detection, diagnosis and treatment of diseases as well as monitoring therapeutic progress in a patient with a disease are provided herein.

Abstract: A test system comprising a reactor having a fluid circuit and a test zone for an item under test. A plurality of control zones are included in the fluid circuit for controlling parameters of the fluid in accordance with control information. A control system receives input data specifying test values for the fluid parameters, predicts the behaviour of the fluid using the input data and a mathematical model of the reactor, calculates control information based on the predicted fluid behaviour, and communicates the control information to the control zones. The system can simulate transient test conditions by selective use of fluid evacuation and dilution, and by use of temperature and flow bypass circuits.

Abstract: A turbine blade or vane inspection apparatus comprising a controller, mounting for holding a turbine blade or vane, a source of illumination, and a camera. At least two of the source of illumination, the camera, and the mounting are moveable components. The controller is configured to control the moveable components to (a) position the turbine blade or vane mounted thereon relative to the illumination source so as to provide a contrast of illumination between a feature of the turbine blade or vane and an adjacent surface of the turbine blade or vane and (b), position the camera so that the optical axis of the camera is directed towards the feature. The controller is further configured to determine a dimension and/or shape of the feature based on an image obtained by the camera.

Abstract: Systems and methods for a wireless controller are provided. The wireless controller includes an enclosure having a top and a bottom, each having a substantially circular perimeter, and a side having a height circumferentially around the perimeter of the top and the bottom. A first sensor is configured to detect movement of the enclosure. A processor is coupled to the first sensor and configured to process signals from the first sensor and to send command signals via a wireless interface based at least upon the signals from the first sensor.

Abstract: An embodiment of a fire-suppression water-intake valve includes a receptacle and a valve assembly. The receptacle is configured to receive a sprinkler head. And the valve assembly is configured to close in response to removing a sprinkler head from the receptacle, and is configured to open in response to installing a sprinkler head in the receptacle. Such a fire-suppression water-intake valve can allow quick and easy removal and installation of a fire-suppression sprinkler head without shutting a water supply to the valve.

Abstract: An improved guidewire may include an elongate shaft including a distal section and a proximal section extending proximally from the distal section. The elongate shaft includes a coiled portion disposed within the distal section. The coiled portion is curved in a first direction in a first plane. The elongate shaft includes a reverse curve portion curved in a second direction opposite the first direction. The reverse curve portion is disposed proximal of the coiled portion. A kit for forming the improved guidewire may include a guidewire having a coiled portion and a forming tool configured to form a reverse curve portion in the guidewire proximal of the coiled portion.