Abstract: The complex chemistry underlying the extensive transformations involved in terpene indole alkaloid synthesis makes identification of the biosynthetic genes challenging. The present invention relates to methods for producing a terpene indole alkaloid derivative, comprising the steps of: (1) providing a terpene indole alkaloid; and (2) providing a first enzyme termed “Precondylocarpine Acetate Synthase” (PAS) or a functional variant or homologue thereof; and/or a second enzyme termed “Dehydroprecondylocarpine Acetate Synthase” (DPAS) or a functional variant or homologue thereof, and optionally providing further identified enzymes involved in this pathway. The invention also encompasses related kits, enzymes, expression vectors, host cells and plants.

Abstract: Described herein are RPE cells engineered to secrete a GLA protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating Fabry disease.

Abstract: A method and apparatus for generating a virtual reality environment. Data requirements for generating the virtual reality environment are identified. The virtual reality environment includes objects that are displayed on a display system using a group of models defined by a group of standards. Discrete points for the objects are generated from the models based on the data requirements for generating the virtual reality environment for a selected point in time. At least one of color adjustments or contour adjustments is identified for a portion of the discrete points based on the group of standards and the data requirements when adjustments are needed. The discrete points are modified based on at least one of the color adjustments or the contour adjustments identified to form modified discrete points, which enable generating the virtual reality environment with a desired level of accuracy for training.

Abstract: A cushioning device includes a machine-washable polyurethan viscoelastic foam and a cavity for receiving a filler.

Abstract: A circuit is for protecting memory address data. The circuit may include an input data bus configured to receive write data to be written to a memory device, and an address bus configured to receive a corresponding write address. The circuit may also include an output data bus, and an address protection circuit coupled to the input data, address, and output data buses and configured to generate an address protection value based on the corresponding write address, and generate modified write data, on the output data bus. The modified write data includes the write data and the address protection value. The output data bus may have a width greater than a width of the input data bus.

Abstract: A circuit is for protecting memory address data. The circuit may include an input data bus configured to receive write data to be written to a memory device, and an address bus configured to receive a corresponding write address. The circuit may also include an output data bus, and an address protection circuit coupled to the input data, address, and output data buses and configured to generate an address protection value based on the corresponding write address, and generate modified write data, on the output data bus. The modified write data includes the write data and the address protection value. The output data bus may have a width greater than a width of the input data bus.

Abstract: A cushioning device includes a machine-washable polyurethan viscoelastic foam and a cavity for receiving a filler.

Abstract: A method and apparatus for generating a virtual reality environment. Data requirements for generating the virtual reality environment are identified. The virtual reality environment includes objects that are displayed on a display system using a group of models defined by a group of standards. Discrete points for the objects are generated from the models based on the data requirements for generating the virtual reality environment for a selected point in time. At least one of color adjustments or contour adjustments is identified for a portion of the discrete points based on the group of standards and the data requirements when adjustments are needed. The discrete points are modified based on at least one of the color adjustments or the contour adjustments identified to form modified discrete points, which enable generating the virtual reality environment with a desired level of accuracy for training.

Abstract: A cushioning device containing a machine-washable polyurethane viscoelastic foam.

Abstract: A pathogen detector has a sample area for containing environmental air, a light source on one side of the sample area for directing a collimated beam of light through the sample air so that part of the light beam will be scattered by any particles present in the air while the remainder remains unscattered, and a beam blocking device on the opposite side of the sample area for blocking at least the unscattered portion of the beam of light and directing at least part of the scattered light onto a detector. The detector produces output pulses in which each pulse has a height proportional to particle size and a pulse height discriminator obtains the size distribution of airborne particles detected in the air sample at a given time from the detector output. An alarm signal is activated if the number of particles within a predetermined pathogen size range of around 1 to 7 ?m exceeds a predetermined normal level.

Abstract: A method and an apparatus for starting a gas turbine engine under various conditions are used to distribute a varying total amount of electric power to at least one of a starter, a fuel heater and an oil heater while providing fuel.

Abstract: A headrest with pivotable side support members and safety features. A head support assembly according to one embodiment includes a first wing member including a deformable plastic wing frame portion. The head support assembly also includes a center member that includes a plastic center frame portion to which the first wing member is pivotably coupled. The forward pivoting of the first wing member is limited an acute angle.

Abstract: A method of engine starting in a gas turbine engine comprises rotating the engine to provide an air flow into a combustor of the engine and injecting fuel into the combustor at a varying rate until the engine is lighted-off. The varying rate of the fuel flow is a function of time and is represented by a curve having at least one high frequency with respect to a light-off time, representing instant changes of the rate for intersecting a light-off zone while reducing a quantity of fuel injected into the combustor. After the light-off occurrence fuel is continuously injected into the combustor to accelerate the engine to a self-sustaining operation condition. This method of the present invention is adapted to find light-off points under various temperature and altitude conditions, thereby advantageously providing a rapid light-off, particularly under cold weather conditions.

Abstract: The present invention relates to a new and novel device constructed so as to prevent damage to a manually operated remote control device capable of controlling the operation of a television or other electronic equipment, the shock absorbing unit being of unitary construction having at both of its ends identical cavity structures capable of encapsulating the ends of a manually operated remote control device, the cavity structures being affixed to a singular band member resulting in there being provided shock absorbing means about all surfaces of the manually operated remote control device thereby protecting same from damage.

Abstract: In a dental x-ray tube head, the x-ray tube is in a casing that supports the tube and shields against stray radiation being projected to the environment through the housing of the tube head. The casing has an aperture for exit of the primary x-ray beam which is directed toward the examination subject. A hollow conical casting extension has its open-ended base intergral with the lower wall of the housing and its open apex end proximate to the aperture in the shield casing. A hollow conical liner comprised of x-ray absorbent material is fastened in the conical casting extension. The shield casing and liner are comprised of resin which is impregnated with barium sulphate.