Patents by Inventor Richard O. Snyder

Richard O. Snyder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection Methods for Target DNA
    Publication number: 20150140554
    Abstract: The invention pertains to a safe, quick and reliable method of detecting the presence of a target DNA sequence in a sample. The invention also pertains to a system for detecting presence of a target DNA sequence in a biological sample. The system includes an ITC template that includes a probe binding sequence that binds to a corresponding ITC probe and a first and second flanking primer recognizing sequence that binds to a first and second primer, respectively. The system also includes an ITC probe that binds to the ITC template probe binding sequence. The ITC probe includes a first marker molecule. The system also includes a first primer that binds to the first flanking primer sequence and a second primer that binds to said second primer sequence. The system further includes a target DNA sequence probe, wherein the target DNA sequence probe comprises a second marker molecule.
    Type: Application
    Filed: February 1, 2012
    Publication date: May 21, 2015
    Inventors: Richard O. Snyder, Phillipe Moullier, Weiyi Ni, Caroline LeGuiner
  • Production of recombinant AAV virions
    Patent number: 7927585
    Abstract: Stocks of infectious rAAV are generated using yeast strains, bacterial strains, and bacteriophages engineered to express the required AAV proteins and harboring rAAV vector sequences. Stocks of rAAV virions of all serotypes and pseudotypes can be generated in prokaryotic and eukaryotic cells using the methods described herein.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: April 19, 2011
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Richard O. Snyder
  • PRODUCTION OF RECOMBINANT AAV VIRIONS
    Publication number: 20090075357
    Abstract: Stocks of infectious rAAV are generated using yeast strains, bacterial strains, and bacteriophages engineered to express the required AAV proteins and harboring rAAV vector sequences. Stocks of rAAV virions of all serotypes and pseudotypes can be generated in prokaryotic and eukaryotic cells using the methods described herein.
    Type: Application
    Filed: January 25, 2008
    Publication date: March 19, 2009
    Applicant: University of Florida Research Foundation, Inc.
    Inventor: RICHARD O. SNYDER
  • Production of pseudotyped recombinant AAV virions
    Patent number: 7094604
    Abstract: Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped recombinant AAV (rAAV) virions. Purification methods generated pseudotyped rAAV virion stocks that were 99% pure with titers of 1×1012–1×1013 vector genomes/ml.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: August 22, 2006
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Richard O. Snyder, Sergei Zolotukhin, Yoshihisa Sakai, Barry J. Byrne, Mark R. Potter, Irine Zolotukhin, Scott Loiler, Vince A. Chiodo, Nicholas Muzyczka, William W. Hauswirth, Terence R. Flotte, Corinna Burger, Edgardo Rodriguez, Kevin R. Nash, Thomas J. Fraites
  • Adeno-associated viral vector-mediated delivery of DNA to cells of the liver
    Patent number: 6936243
    Abstract: The instant invention provides methods of expressing polynucleotides in the cells of the liver comprising administering viral particles comprising a recombinant AAV vector into a mammal, preferably a human.
    Type: Grant
    Filed: May 22, 2000
    Date of Patent: August 30, 2005
    Assignees: The University of Washington, Cell Genesys, Inc.
    Inventors: Richard O. Snyder, Lawrence K. Cohen, Mark A. Kay, Olivier Danos, Arthur R. Thompson
  • Production of pseudotyped recombinant AAV virions
    Publication number: 20040209245
    Abstract: Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped recombinant AAV (rAAV) virions. Purification methods generated pseudotyped rAAV virion stocks that were 99% pure with titers of 1×1012-1×1013 vector genomes/ml.
    Type: Application
    Filed: March 11, 2004
    Publication date: October 21, 2004
    Inventors: Richard O. Snyder, Sergei Zolotukhin, Yoshihisa Sakai, Barry J. Byrne, Mark R. Potter, Irine Zolotukhin, Scott Loiler, Vince A. Chiodo, Nicholas Muzyczka, William W. Hauswirth, Terence R. Flotte, Corinna Burger, Edgardo Rodriguez, Kevin R. Nash, Thomas J. Fraites
  • Recombinant AAV vectors for gene therapy of hemophilia A
    Patent number: 6797505
    Abstract: The instant invention provides methods and materials for expressing a polypeptide with factor VIII activity comprising administering an rAAV vector encoding a truncated version of human factor VIII, containing, for example, a 90 kD heavy chain of factor VIII fused to a light chain of factor VIII.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: September 28, 2004
    Assignee: Cell Genesys, Inc.
    Inventors: Richard O. Snyder, Thomas J. Dull, Ryan McGuinness, Mitchell H. Finer
  • Recombinant AAV vectors for gene therapy of hemophilia A
    Publication number: 20040092008
    Abstract: The instant invention provides methods and materials for expressing a polypeptide with factor VIII activity comprising administering an rAAV vector encoding a truncated version of human factor VIII, containing, for example, a 90 kD heavy chain of factor VIII fused to a light chain of factor VIII.
    Type: Application
    Filed: November 12, 2002
    Publication date: May 13, 2004
    Inventors: Richard O. Snyder, Thomas J. Dull, Ryan McGuinness, Mitchell H. Finer
  • Production of recombinant AAV virions
    Publication number: 20030225260
    Abstract: Stocks of infectious rAAV are generated using yeast strains, bacterial strains, and bacteriophages engineered to express the required AAV proteins and harboring rAAV vector sequences. Stocks of rAAV virions of all serotypes and pseudotypes can be generated in prokaryotic and eukaryotic cells using the methods described herein.
    Type: Application
    Filed: April 30, 2003
    Publication date: December 4, 2003
    Inventor: Richard O. Snyder
  • Use of suppressor tRNA's to regulate cytotoxicity during the production of recombinant gene products
    Patent number: 6586208
    Abstract: Suppressor tRNA's are used to regulate expression of transgenes that are toxic, or the expression thereof requires a factor that is toxic, to the host cell.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: July 1, 2003
    Assignee: Cell Genesys, Inc.
    Inventors: Brian A. Donahue, Stephen F. Hardy, Richard O. Snyder
  • Adeno-associated viral vector-mediated delivery of DNA to cells of the liver
    Publication number: 20020151509
    Abstract: The instant invention provides methods of expressing polynucleotides in the cells of the liver comprising administering viral particles comprising a recombinant AAV vector into a mammal, preferably a human.
    Type: Application
    Filed: May 22, 2000
    Publication date: October 17, 2002
    Inventors: Richard O. Snyder, Lawrence K. Cohen, Mark A. Kay, Oliver Danos, Arthur R. Thompson
  • Use of suppressor tRNA's to regulate cytotoxicity during the production of recombinant gene products
    Publication number: 20020076808
    Abstract: Suppressor tRNA's are used to regulate expression of transgenes that are toxic, or the expression thereof requires a factor that is toxic, to the host cell.
    Type: Application
    Filed: February 16, 2001
    Publication date: June 20, 2002
    Inventors: Brian A. Donahue, Stephen F. Hardy, Richard O. Snyder