Patents by Inventor Richard Oakley Nicholas

Richard Oakley Nicholas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds
    Patent number: 7176299
    Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: February 13, 2007
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Michael Terence Black, Martin Karl Russell Burnham, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard Oakley Nicholas, Leslie Marie Palmer, Julie M. Pratt, Raymond Winfield Reichard, Martin Rosenberg, Christopher Michael Traini, Judith M. Ward, Richard Lloyd Warren
  • ribG
    Publication number: 20040265872
    Abstract: The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: April 14, 2004
    Publication date: December 30, 2004
    Applicant: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, Martin Karl Russell Burnham, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard Oakley Nicholas, Leslie Marie Palmer, Julie M. Pratt, Raymond Winfield Reichard, Martin Rosenberg, Christopher Michael Traini, Judith M. Ward, Richard Lloyd Warren
  • Member of ATP dependent protease family, clpL
    Patent number: 6447773
    Abstract: The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: September 10, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Andrew Fosberry, Elizabeth J Lawlor
  • ribB
    Patent number: 6448036
    Abstract: The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: September 10, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, Martin Karl Russell Burnham, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard Oakley Nicholas, Leslie Marie Palmer, Julie M Pratt, Raymond Winfield Reichard, Martin Rosenberg, Christopher Michael Traini, Judith M Ward, Richard Lloyd Warren
  • Novel ribB
    Publication number: 20020091236
    Abstract: The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 18, 2001
    Publication date: July 11, 2002
    Inventors: Michael Terence Black, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Anna Lisa Kosmatka, Richard Oakley Nicholas, Leslie Marie Palmer, Lisa Kathleen Shilling, Robert King Stodola, Richard Lloyd Warren
  • Novel era
    Publication number: 20020086385
    Abstract: The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: March 29, 2001
    Publication date: July 4, 2002
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard Oakley Nicholas, Leslie Marie Palmer, Robert Reid, Martin Rosenberg, Phillip Zarfos
  • Apt
    Patent number: 6348578
    Abstract: The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: February 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Arthur Lonetto, Richard Oakley Nicholas, James Raymond Brown, Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Robert King Stodola, Magdalena Zalacain
  • Compounds
    Patent number: 6348328
    Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
    Type: Grant
    Filed: May 14, 1997
    Date of Patent: February 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc.
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Richard Oakley Nicholas, Robert King Stodola
  • PAI
    Patent number: 6344540
    Abstract: The invention provides pai polypeptides and DNA (RNA) encoding pai polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pai polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: February 5, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • ribG
    Patent number: 6335424
    Abstract: The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: January 1, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: Michael Terence Black, Christine Debouck, Jason Craig Fedon, John Edward Hodgson, Deborah Dee Jaworski, David Justin Charles Knowles, Anna Lisa Kosmatka, Jeffrey Mooney, Richard Oakley Nicholas, Leslie Marie Palmer, Lisa Kathleen Shilling, Robert King Stodola, Min Wang, Richard Lloyd Warren, Yi Yi Zhong
  • PhoH homolog
    Patent number: 6323336
    Abstract: The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: November 27, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • GbpA
    Patent number: 6320036
    Abstract: The invention provides gbpA polypeptides and DNA (RNA) encoding gbpA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gbpA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: November 20, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Polynucleotides encoding a novel era polypeptide
    Patent number: 6287803
    Abstract: The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 6, 1997
    Date of Patent: September 11, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard Oakley Nicholas, Leslie Marie Palmer, Robert H. Reid, Martin Rosenberg, Phillip Zarfos
  • def1
    Patent number: 6284878
    Abstract: The invention provides def1 polypeptides and polynucleotides encoding def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def1 polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: September 4, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: Michael Arthur Lonetto, Deborah Dee Jaworski, Min Wang, Richard Lloyd Warren, Christopher Michael Traini, Anna Lisa Kosmatka, David Justin Charles Knowles, John Edward Hodgson, Michael Terence Black, David J. Holmes, Richard Oakley Nicholas, Robert King Stodola
  • ribG
    Patent number: 6280735
    Abstract: The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 6, 1999
    Date of Patent: August 28, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beechman plc
    Inventors: Michael Terence Black, Martin Karl Russell Burnham, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard Oakley Nicholas, Leslie Marie Palmer, Julie M Pratt, Raymond Winfield Reichard, Martin Rosenberg, Christopher Michael Traini, Judith M Ward, Richard Lloyd Warren
  • Polynucleotides encoding GTP cyclohydrolase II (RIBA)
    Patent number: 6280971
    Abstract: The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: August 28, 2001
    Assignees: SmithKline Beecham Corporatiion, SmithKline Beecham plc
    Inventors: Min Wang, Judith M Ward, Richard Lloyd Warren, Richard Oakley Nicholas, Leslie Marie Palmer, Julie M Pratt, David Justin Charles Knowles, Michael Arthur Lonetto, Jeffrey Mooney, Michael Terence Black, Martin Karl Russell Burnham, Christine Debouck, Jason Craig Fedon, John Edward Hodgson, Deborah Dee Jaworski, Raymond Winfield Reichard, Martin Rosenberg, Christopher Michael Traini, Yi Y Zhong
  • ClpL
    Patent number: 6274376
    Abstract: The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing clpL polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 4, 1997
    Date of Patent: August 14, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Andrew Fosberry, Elizabeth J Lawlor
  • Ribb
    Patent number: 6252044
    Abstract: The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: June 26, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terance Black, Lisa Kathleen Shilling, Robert King Stodola, Richard Lloyd Warren, Anna Lisa Kosmatka, Richard Oakley Nicholas, Leslie Marie Palmer, Michael Arthur Lonetto, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles
  • yitJ
    Patent number: 6251652
    Abstract: The invention provides yitJ polypeptides and DNA (RNA) encoding yitJ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yitJ polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: June 26, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Jamie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Phoh homolog
    Patent number: 6248863
    Abstract: The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for anitbacterial compounds.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: June 19, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren