Abstract: Systems and methods for the modification of an aircraft landing pattern through a graphical user interface. The graphical user interface provides buttons associated with flight maneuvers that, when selected, trigger an autopilot of the aircraft to perform the corresponding maneuver. The maneuvers may include a loitering maneuver such as a 360 degree maneuver, a downwind extension maneuver and a turn to base maneuver.

Abstract: Provided herein are methods, compositions and uses involving T cell therapies, such as adoptive T cell therapy, and an inhibitor of a Diacylglycerol kinase (DGK). The provided methods, compositions and uses include those involving the administration or use of one or more DGK inhibitors (DGKi) in a combination therapy with a T cell therapy, such as a genetically engineered T cell therapy involving cells engineered with a recombinant receptor, such as chimeric antigen receptor (CAR) or T cell receptor (TCR).

Abstract: An air cleaner arrangement or assembly is provided. The air cleaner arrangement includes a serviceable filter cartridge. The air cleaner assembly also includes an arrangement for positioning the filter cartridge into a preferred, sealing, orientation and for securing the filter cartridge in that location. Preferred serviceable filter cartridges are provided, as well as methods of assembly and use.

Abstract: In an embodiment, an apparatus includes one or more probes, a tip, a pin, and a measurement device. The one or more probes may be configured for insertion through an aperture in a component. The tip may be slidably engaged with the one or more probes and include a first end configured to contact a first surface of the component. The first end of the tip may be conically shaped. The pin may be slidably engaged with the one or more probes and include a first end configured for insertion into the aperture in the component such that the one or more probes are configured to contact a second surface of the component. The pin may be configured to move between a first position and a second position. An axis of the pin may be substantially aligned with an axis of the tip. The measurement device may be coupled to the tip and configured to measure a value indicating a grip length.

Abstract: In one embodiment, systems and methods include using an inspection system to remove or seal foreign object debris. An inspection system comprises a borescope; wherein a plurality of optical fibers is disposed within the borescope; a mounting system; an articulation system; and a controller, wherein the controller comprises a display; wherein a proximal end of the borescope is coupled to the mounting system, wherein the mounting system is configured to secure the inspection system to an external surface, wherein the mounting system is coupled to the articulation system, wherein the articulation system is configured to actuate the borescope, wherein the articulation system is communicatively coupled to the controller.

Abstract: The present invention relates to antisense oligonucleotides that are capable of modulating expression of MYH7 in a target cell. The oligonucleotides hybridize to MYH7 mRNA. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods for treatment of hypertrophic cardiomyopathy using the oligonucleotide.

Abstract: In an embodiment, an apparatus includes one or more probes, a tip, a pin, and a measurement device. The one or more probes may be configured for insertion through an aperture in a component. The tip may be slidably engaged with the one or more probes and include a first end configured to contact a first surface of the component. The first end of the tip may be conically shaped. The pin may be slidably engaged with the one or more probes and include a first end configured for insertion into the aperture in the component such that the one or more probes are configured to contact a second surface of the component. The pin may be configured to move between a first position and a second position. An axis of the pin may be substantially aligned with an axis of the tip. The measurement device may be coupled to the tip and configured to measure a value indicating a grip length.

Abstract: An air cleaner arrangement or assembly is provided. The air cleaner arrangement includes a serviceable filter cartridge. The air cleaner assembly also includes an arrangement for positioning the filter cartridge into a preferred, sealing, orientation and for securing the filter cartridge in that location. Preferred serviceable filter cartridges are provided, as well as methods of assembly and use.

Abstract: An apparatus is for use with a pillar adjacent to a vehicle window, such as a windshield. The apparatus includes a molding for positioning adjacent to the pillar, the molding forming a channel in a deployed condition for receiving moisture from the vehicle windshield, or for reducing the effects of wind throb when a single vehicle window is open. An actuator may be associated with the molding for activating a non-deployed condition of the molding for reducing the effects of wind noise. The molding may include a passage for receiving an airflow and transmitting it to an outlet for directing fluid away from the molding, the pillar and adjacent side window. In the deployed condition, the molding may project from a surface of the pillar and in the non-deployed condition may be substantially flush with the surface of the pillar.

Abstract: An air cleaner arrangement or assembly is provided. The air cleaner arrangement includes a serviceable filter cartridge. The air cleaner assembly also includes an arrangement for positioning the filter cartridge into a preferred, sealing, orientation and for securing the filter cartridge in that location. Preferred serviceable filter cartridges are provided, as well as methods of assembly and use.

Abstract: 2-pyrrolino-13-deoxyanthracycline derivatives, medical uses thereof, and a process for making them. A 2-pyrrolino-13-deoxyanthracycline and a 13-deoxyanthracycline can be administered to a patient simultaneously or sequentially in amounts to produce a synergistic therapeutic effect with increased potency and efficacy, compared to the sum of the effects of each drug when administered alone. A composition or preparation of a 2-pyrrolino-13-deoxyanthracycline and a 13-deoxyanthracycline for producing a potent anticancer therapeutic effect is also provided.

Abstract: An apparatus is for use with a pillar adjacent to a vehicle window, such as a windshield. The apparatus includes a molding for positioning adjacent to the pillar, the molding forming a channel in a deployed condition for receiving moisture from the vehicle windshield, or for reducing the effects of wind throb when a single vehicle window is open. An actuator may be associated with the molding for activating a non-deployed condition of the molding for reducing the effects of wind noise. The molding may include a passage for receiving an airflow and transmitting it to an outlet for directing fluid away from the molding, the pillar and adjacent side window. In the deployed condition, the molding may project from a surface of the pillar and in the non-deployed condition may be substantially flush with the surface of the pillar.

Abstract: An apparatus is for use with a pillar adjacent to a vehicle window, such as a windshield. The apparatus includes a molding for positioning adjacent to the pillar, the molding forming a channel in a deployed condition for receiving moisture from the vehicle windshield, or for reducing the effects of wind throb when a single vehicle window is open. An actuator may be associated with the molding for activating a non-deployed condition of the molding for reducing the effects of wind noise. The molding may include a passage for receiving an airflow and transmitting it to an outlet for directing fluid away from the molding, the pillar and adjacent side window. In the deployed condition, the molding may project from a surface of the pillar and in the non-deployed condition may be substantially flush with the surface of the pillar.

Abstract: An apparatus is for use with a pillar adjacent to a vehicle window, such as a windshield. The apparatus includes a molding for positioning adjacent to the pillar, the molding forming a channel in a deployed condition for receiving moisture from the vehicle windshield, or for reducing the effects of wind throb when a single vehicle window is open. An actuator may be associated with the molding for activating a non-deployed condition of the molding for reducing the effects of wind noise.

Abstract: An air cleaner arrangement or assembly is provided. The air cleaner arrangement includes a serviceable filter cartridge. The air cleaner assembly also includes an arrangement for positioning the filter cartridge into a preferred, sealing, orientation and for securing the filter cartridge in that location. Preferred serviceable filter cartridges are provided, as well as methods of assembly and use.

Abstract: 2-pyrrolino-13-deoxyanthracycline derivatives, medical uses thereof, and a process for making them. A 2-pyrrolino-13-deoxyanthracycline and a 13-deoxyanthracycline can be administered to a patient simultaneously or sequentially in amounts to produce a synergistic therapeutic effect with increased potency and efficacy, compared to the sum of the effects of each drug when administered alone. A composition or preparation of a 2-pyrrolino-13-deoxyanthracycline and a 13-deoxyanthracycline for producing a potent anticancer therapeutic effect is also provided.

Abstract: An air cleaner arrangement or assembly is provided. The air cleaner arrangement includes a serviceable filter cartridge. The air cleaner assembly also includes an arrangement for positioning the filter cartridge into a preferred, sealing, orientation and for securing the filter cartridge in that location. Preferred serviceable filter cartridges are provided, as well as methods of assembly and use.

Abstract: An apparatus is for use with a pillar adjacent to a vehicle window, such as a windshield. The apparatus includes a molding for positioning adjacent to the pillar, the molding forming a channel in a deployed condition for receiving moisture from the vehicle windshield, or for reducing the effects of wind throb when a single vehicle window is open. An actuator may be associated with the molding for activating a non-deployed condition of the molding for reducing the effects of wind noise. The molding may include a passage for receiving an airflow and transmitting it to an outlet for directing fluid away from the molding, the pillar and adjacent side window. In the deployed condition, the molding may project from a surface of the pillar and in the non-deployed condition may be substantially flush with the surface of the pillar.

Abstract: An apparatus is for use with a pillar adjacent to a vehicle window, such as a windshield. The apparatus includes a molding for positioning adjacent to the pillar, the molding forming a channel in a deployed condition for receiving moisture from the vehicle windshield, or for reducing the effects of wind throb when a single vehicle window is open. An actuator may be associated with the molding for activating a non-deployed condition of the molding for reducing the effects of wind noise.

Abstract: An air cleaner arrangement or assembly is provided. The air cleaner arrangement includes a serviceable filter cartridge. The air cleaner assembly also includes an arrangement for positioning the filter cartridge into a preferred, sealing, orientation and for securing the filter cartridge in that location. Preferred serviceable filter cartridges are provided, as well as methods of assembly and use.