Abstract: The present invention extends to wagons with a bathroom module and standalone bathroom modules. A bathroom module includes a water heater connected to a sink, a shower, and a toilet. The bathroom module further includes a protective layer on the exterior and an exhaust fan to facilitate the management of moisture that may build up within the bathroom module. The bathroom module can be connected to various systems provided by a wagon, such as water, gas, electrical, A/C, heat, and sewer systems connected to external sources. Alternatively, the bathroom module can standalone and include its own water, gas, electrical, A/C, heat, and sewer systems connected to external sources. Thus, when paired with a companion wagon, the bathroom module may be installed or removed as desired.

Abstract: Provided herein are methods, compositions and uses involving T cell therapies, such as adoptive T cell therapy, and an inhibitor of a Diacylglycerol kinase (DGK). The provided methods, compositions and uses include those involving the administration or use of one or more DGK inhibitors (DGKi) in a combination therapy with a T cell therapy, such as a genetically engineered T cell therapy involving cells engineered with a recombinant receptor, such as chimeric antigen receptor (CAR) or T cell receptor (TCR).

Abstract: Antimicrobial compositions including at least one acid and at least one anionic surfactant are provided. In particular, food contact antimicrobial compositions including at least one acid and at least one anionic surfactant provide efficacious virucidal activity, including against Norovirus, having acceptable use solution pH that do not require use of personal protective equipment (PPE), are surface compatible and do not leave residues on treated surfaces. Methods of cleaning a surface with the compositions are also provided and may beneficially eliminate the need to rinse the antimicrobial compositions after use.

Abstract: A surgically implanted occluding assembly comprises an implant body having a longitudinally split generally “C”-shaped cross-section tube circumscribing an anatomical lumen. In one embodiment, the surgically implanted occluding assembly is a male continence device selectively occluding a urethra. In some embodiments an occluding magnet is rigidly affixed with the implant body, and an external selective occlusion control assembly is used to selectively activate the surgically implanted occluding assembly. The external assembly has a magnet, and body supporting the magnet. The external selective occlusion control assembly is configured to be selectively placed and retained adjacent to the surgically implanted occluding assembly.

Abstract: An air cleaner arrangement or assembly is provided. The air cleaner arrangement includes a serviceable filter cartridge. The air cleaner assembly also includes an arrangement for positioning the filter cartridge into a preferred, sealing, orientation and for securing the filter cartridge in that location. Preferred serviceable filter cartridges are provided, as well as methods of assembly and use.

Abstract: In an embodiment, an apparatus includes one or more probes, a tip, a pin, and a measurement device. The one or more probes may be configured for insertion through an aperture in a component. The tip may be slidably engaged with the one or more probes and include a first end configured to contact a first surface of the component. The first end of the tip may be conically shaped. The pin may be slidably engaged with the one or more probes and include a first end configured for insertion into the aperture in the component such that the one or more probes are configured to contact a second surface of the component. The pin may be configured to move between a first position and a second position. An axis of the pin may be substantially aligned with an axis of the tip. The measurement device may be coupled to the tip and configured to measure a value indicating a grip length.

Abstract: In one embodiment, systems and methods include using an inspection system to remove or seal foreign object debris. An inspection system comprises a borescope; wherein a plurality of optical fibers is disposed within the borescope; a mounting system; an articulation system; and a controller, wherein the controller comprises a display; wherein a proximal end of the borescope is coupled to the mounting system, wherein the mounting system is configured to secure the inspection system to an external surface, wherein the mounting system is coupled to the articulation system, wherein the articulation system is configured to actuate the borescope, wherein the articulation system is communicatively coupled to the controller.

Abstract: The present invention relates to antisense oligonucleotides that are capable of modulating expression of MYH7 in a target cell. The oligonucleotides hybridize to MYH7 mRNA. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods for treatment of hypertrophic cardiomyopathy using the oligonucleotide.

Abstract: In an embodiment, an apparatus includes one or more probes, a tip, a pin, and a measurement device. The one or more probes may be configured for insertion through an aperture in a component. The tip may be slidably engaged with the one or more probes and include a first end configured to contact a first surface of the component. The first end of the tip may be conically shaped. The pin may be slidably engaged with the one or more probes and include a first end configured for insertion into the aperture in the component such that the one or more probes are configured to contact a second surface of the component. The pin may be configured to move between a first position and a second position. An axis of the pin may be substantially aligned with an axis of the tip. The measurement device may be coupled to the tip and configured to measure a value indicating a grip length.

Abstract: An air cleaner arrangement or assembly is provided. The air cleaner arrangement includes a serviceable filter cartridge. The air cleaner assembly also includes an arrangement for positioning the filter cartridge into a preferred, sealing, orientation and for securing the filter cartridge in that location. Preferred serviceable filter cartridges are provided, as well as methods of assembly and use.

Abstract: An apparatus is for use with a pillar adjacent to a vehicle window, such as a windshield. The apparatus includes a molding for positioning adjacent to the pillar, the molding forming a channel in a deployed condition for receiving moisture from the vehicle windshield, or for reducing the effects of wind throb when a single vehicle window is open. An actuator may be associated with the molding for activating a non-deployed condition of the molding for reducing the effects of wind noise. The molding may include a passage for receiving an airflow and transmitting it to an outlet for directing fluid away from the molding, the pillar and adjacent side window. In the deployed condition, the molding may project from a surface of the pillar and in the non-deployed condition may be substantially flush with the surface of the pillar.

Abstract: An air cleaner arrangement or assembly is provided. The air cleaner arrangement includes a serviceable filter cartridge. The air cleaner assembly also includes an arrangement for positioning the filter cartridge into a preferred, sealing, orientation and for securing the filter cartridge in that location. Preferred serviceable filter cartridges are provided, as well as methods of assembly and use.

Abstract: 2-pyrrolino-13-deoxyanthracycline derivatives, medical uses thereof, and a process for making them. A 2-pyrrolino-13-deoxyanthracycline and a 13-deoxyanthracycline can be administered to a patient simultaneously or sequentially in amounts to produce a synergistic therapeutic effect with increased potency and efficacy, compared to the sum of the effects of each drug when administered alone. A composition or preparation of a 2-pyrrolino-13-deoxyanthracycline and a 13-deoxyanthracycline for producing a potent anticancer therapeutic effect is also provided.

Abstract: An apparatus is for use with a pillar adjacent to a vehicle window, such as a windshield. The apparatus includes a molding for positioning adjacent to the pillar, the molding forming a channel in a deployed condition for receiving moisture from the vehicle windshield, or for reducing the effects of wind throb when a single vehicle window is open. An actuator may be associated with the molding for activating a non-deployed condition of the molding for reducing the effects of wind noise. The molding may include a passage for receiving an airflow and transmitting it to an outlet for directing fluid away from the molding, the pillar and adjacent side window. In the deployed condition, the molding may project from a surface of the pillar and in the non-deployed condition may be substantially flush with the surface of the pillar.

Abstract: An apparatus is for use with a pillar adjacent to a vehicle window, such as a windshield. The apparatus includes a molding for positioning adjacent to the pillar, the molding forming a channel in a deployed condition for receiving moisture from the vehicle windshield, or for reducing the effects of wind throb when a single vehicle window is open. An actuator may be associated with the molding for activating a non-deployed condition of the molding for reducing the effects of wind noise. The molding may include a passage for receiving an airflow and transmitting it to an outlet for directing fluid away from the molding, the pillar and adjacent side window. In the deployed condition, the molding may project from a surface of the pillar and in the non-deployed condition may be substantially flush with the surface of the pillar.

Abstract: An apparatus is for use with a pillar adjacent to a vehicle window, such as a windshield. The apparatus includes a molding for positioning adjacent to the pillar, the molding forming a channel in a deployed condition for receiving moisture from the vehicle windshield, or for reducing the effects of wind throb when a single vehicle window is open. An actuator may be associated with the molding for activating a non-deployed condition of the molding for reducing the effects of wind noise.

Abstract: An air cleaner arrangement or assembly is provided. The air cleaner arrangement includes a serviceable filter cartridge. The air cleaner assembly also includes an arrangement for positioning the filter cartridge into a preferred, sealing, orientation and for securing the filter cartridge in that location. Preferred serviceable filter cartridges are provided, as well as methods of assembly and use.

Abstract: 2-pyrrolino-13-deoxyanthracycline derivatives, medical uses thereof, and a process for making them. A 2-pyrrolino-13-deoxyanthracycline and a 13-deoxyanthracycline can be administered to a patient simultaneously or sequentially in amounts to produce a synergistic therapeutic effect with increased potency and efficacy, compared to the sum of the effects of each drug when administered alone. A composition or preparation of a 2-pyrrolino-13-deoxyanthracycline and a 13-deoxyanthracycline for producing a potent anticancer therapeutic effect is also provided.

Abstract: An air cleaner arrangement or assembly is provided. The air cleaner arrangement includes a serviceable filter cartridge. The air cleaner assembly also includes an arrangement for positioning the filter cartridge into a preferred, sealing, orientation and for securing the filter cartridge in that location. Preferred serviceable filter cartridges are provided, as well as methods of assembly and use.

Abstract: An apparatus is for use with a pillar adjacent to a vehicle window, such as a windshield. The apparatus includes a molding for positioning adjacent to the pillar, the molding forming a channel in a deployed condition for receiving moisture from the vehicle windshield, or for reducing the effects of wind throb when a single vehicle window is open. An actuator may be associated with the molding for activating a non-deployed condition of the molding for reducing the effects of wind noise. The molding may include a passage for receiving an airflow and transmitting it to an outlet for directing fluid away from the molding, the pillar and adjacent side window. In the deployed condition, the molding may project from a surface of the pillar and in the non-deployed condition may be substantially flush with the surface of the pillar.