Patents by Inventor Richard P. Batycky
Richard P. Batycky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7252840Abstract: Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diameter between about 5 and about 30 microns and an aerodynamic diameter between about 1 and about 5 microns. The particles can be formed by spray-drying and are useful for delivery to the pulmonary system.Type: GrantFiled: August 23, 2000Date of Patent: August 7, 2007Assignee: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, Michael M. Lipp, Ralph W. Niven
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Patent number: 7182961Abstract: This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant invention are made by creating hollow, spherical drug particles (i.e., progenitor particles) that collapse in the process of particle formation, leading to wrinkled, thin-walled drug particles of very low envelope density. Additionally, Applicants have found that such particles are especially optimal for inhaled aerosols when the surface area parameter (?) is greater than 2, optimally greater than 3.Type: GrantFiled: November 20, 2002Date of Patent: February 27, 2007Assignee: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, David A. Edwards, Michael M. Lipp
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Patent number: 7008644Abstract: Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneously combined. The present invention optimizes process conditions for increasing and controlling particle porosity. The present invention also allows for optimization of particle size in real-time during particle production.Type: GrantFiled: March 20, 2002Date of Patent: March 7, 2006Assignee: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, Blair C. Jackson, Lloyd P. Johnston, Jeffrey D. Mintzes, Ernest E. Penachio
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Patent number: 6858199Abstract: A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3 and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.Type: GrantFiled: June 9, 2000Date of Patent: February 22, 2005Assignee: Advanced Inhalation Research, Inc.Inventors: David A. Edwards, Richard P. Batycky, Lloyd Johnston
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Patent number: 6848197Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.Type: GrantFiled: April 18, 2001Date of Patent: February 1, 2005Assignees: Advanced Inhalation Research, Inc., The Penn State Research Foundation, Inc.Inventors: Donghao Chen, Richard P. Batycky, Lloyd Johnston, Jeffrey Mintzes
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Publication number: 20040202721Abstract: Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can also include a therapeutic, prophylactic or diagnostic agent. Preferred carboxylic acids include at least two carboxyl groups. Preferred phospholipids include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phophstidylserines, phosphatidylinositols and combinations thereof. The particles are suitable for pulmonary delivery.Type: ApplicationFiled: April 28, 2004Publication date: October 14, 2004Applicant: Advanced Inhalation Research, Inc.Inventors: Michael W. Lipp, Richard P. Batycky, Giovanni Caponetti
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Patent number: 6749835Abstract: Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can also include a therapeutic, prophylactic or diagnostic agent. Preferred carboxylic acids include at least two carboxyl groups. Preferred phospholipids include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phophstidylserines, phosphatidylinositols and combinations thereof. The particles are suitable for pulmonary delivery.Type: GrantFiled: August 23, 2000Date of Patent: June 15, 2004Assignee: Advanced Inhalation Research, Inc.Inventors: Michael W. Lipp, Richard P. Batycky, Giovanni Caponetti
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Publication number: 20040076588Abstract: The present invention is directed toward particles for delivery of epinephrine to the respiratory system and methods for treating a patient in need of epinephrine. The particles and respirable compositions comprising the particles of the present invention described herein comprise the bioactive agent epinephrine, or a salt thereof, as a therapeutic agent. The particles are preferably formed by spray drying. Preferably, the particles and the respirable compositions are substantially dry and are substantially free of propellents. In a preferred embodiment, the particles have aerodynamic characteristics that permit targeted delivery of epinephrine to the site(s) of action.Type: ApplicationFiled: June 26, 2003Publication date: April 22, 2004Inventors: Richard P. Batycky, Giovanni Caponetti, Mariko Childs, Elliot Ehrich, Karen Fu, Jeffrey S. Hrkach, Wen-I Li, Michael M. Lipp, Mei-Ling Pan, Jason Summa
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Publication number: 20030180283Abstract: Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneously combined. The present invention optimizes process conditions for increasing and controlling particle porosity. The present invention also allows for optimization of particle size in real-time during particle production.Type: ApplicationFiled: March 20, 2002Publication date: September 25, 2003Inventors: Richard P. Batycky, Blair C. Jackson, Lloyd P. Johnston, Jeffrey D. Mintzes, Ernest E. Penachio
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Publication number: 20030166509Abstract: The present invention features pharmaceutical compositions comprising nanoparticles containing a sustained release bioactive agent, method of making such compositions, and method of therapy using such compositions.Type: ApplicationFiled: November 20, 2002Publication date: September 4, 2003Applicant: Advanced Inhalation Research, Inc.Inventors: David A. Edwards, Richard P. Batycky, Jennifer L. Schmitke, Nicolas Tsapis, David A. Weitz, Jeffrey S. Hrkach
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Publication number: 20030129139Abstract: This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant invention are made by creating hollow, spherical drug particles (i.e., progenitor particles) that collapse in the process of particle formation, leading to wrinkled, thin-walled drug particles of very low envelope density. Additionally, Applicants have found that such particles are especially optimal for inhaled aerosols when the surface area parameter (&sgr;) is greater than 2, optimally greater than 3.Type: ApplicationFiled: November 20, 2002Publication date: July 10, 2003Applicant: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, David A. Edwards, Michael M. Lipp
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Publication number: 20030129250Abstract: The invention is drawn to particles for oral drug delivery produced by spray-drying a dilute solution of a poorly soluble agent. The particles comprise regions of poorly soluble agent wherein the dissolution rate enhancement is between about 2-fold and about 25-fold compared to the agent in bulk form.Type: ApplicationFiled: November 20, 2002Publication date: July 10, 2003Applicant: Advanced Inhalation Research Inc.Inventors: Richard P. Batycky, George Grandolfi, Sean Plunkett, Michael M. Lipp, James Wright
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Publication number: 20030125236Abstract: The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.Type: ApplicationFiled: June 24, 2002Publication date: July 3, 2003Applicant: Advenced Inhalation Research, Inc.Inventors: Jennifer L. Schmitke, Donghao Chen, Richard P. Batycky, David A. Edwards
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Patent number: 6586008Abstract: Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diameter between about 5 and about 30 microns and an aerodynamic diameter between about 1 and about 5 microns. The particles can be formed by spray-drying and are useful for delivery to the pulmonary system.Type: GrantFiled: August 25, 1999Date of Patent: July 1, 2003Assignee: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, Michael M. Lipp, Ralph W. Niven
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Publication number: 20030017113Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.Type: ApplicationFiled: April 18, 2001Publication date: January 23, 2003Applicant: Advanced Inhalation Research, Inc.Inventors: Donghao Chen, Richard P. Batycky, Lloyd Johnston, Jeffrey Mintzes
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Publication number: 20020141946Abstract: The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.Type: ApplicationFiled: June 22, 2001Publication date: October 3, 2002Applicant: Advanced Inhalation Research, Inc.Inventors: Jennifer L. Schmitke, Donghao Chen, Richard P. Batycky, David A. Edwards, Jeffrey S. Hrkach
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Publication number: 20020035993Abstract: A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Type: ApplicationFiled: June 8, 2001Publication date: March 28, 2002Applicant: Advanced Inhalation Research, Inc.Inventors: David A. Edwards, Richard P. Batycky, Lloyd Johnston